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Research ArticleBRAIN

Comparison of Relative Cerebral Blood Volume and Proton Spectroscopy in Patients with Treated Gliomas

Roland G. Henry, Daniel B. Vigneron, Nancy J. Fischbein, P. Ellen Grant, Mark R. Day, Susan M. Noworolski, Joshua M. Star-Lack, Lawrence L. Wald, William P. Dillon, Susan M. Chang and Sarah J. Nelson
American Journal of Neuroradiology February 2000, 21 (2) 357-366;
Roland G. Henry
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Daniel B. Vigneron
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Nancy J. Fischbein
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P. Ellen Grant
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Mark R. Day
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Susan M. Noworolski
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Joshua M. Star-Lack
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Lawrence L. Wald
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William P. Dillon
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Susan M. Chang
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Sarah J. Nelson
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Abstract

BACKGROUND AND PURPOSE: Elevated relative regional cerebral blood volume (rCBV) reflects the increased microvascularity that is associated with brain tumors. The purpose of this study was to investigate the potential role of rCBV in the determination of recurrent/residual disease in patients with treated gliomas.

METHODS: Thirty-one rCBV studies were performed in 19 patients with treated gliomas. All patients also had proton MR spectroscopy and conventional MR imaging. Regions of abnormality were identified on conventional MR images by two neuroradiologists and compared with rCBV and MR spectroscopic data. Metabolites and rCBV were quantified and compared in abnormal regions.

RESULTS: In high-grade tumors, rCBV values were proportional to choline in regions of tumor and nonviable tissue. Although the presence of residual/recurrent disease was often ambiguous on conventional MR images, the rCBV maps indicated regions of elevated vascularity in all low-grade tumors and in 12 of 17 grade IV lesions. Regions of elevated and low rCBV corresponded well with spectra, indicating tumor and nonviable tissue, respectively.

CONCLUSION: This study suggests that rCBV maps and MR spectroscopy are complementary techniques that may improve the detection of residual/recurrent tumor in patients with treated gliomas. Compared with the spectra, the rCBV maps may better reflect the heterogeneity of the tumor regions because of their higher resolution. The multiple markers of MR spectroscopy enable better discrimination between normal and abnormal tissue than do the rCBV maps.

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American Journal of Neuroradiology
Vol. 21, Issue 2
1 Feb 2000
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Comparison of Relative Cerebral Blood Volume and Proton Spectroscopy in Patients with Treated Gliomas
Roland G. Henry, Daniel B. Vigneron, Nancy J. Fischbein, P. Ellen Grant, Mark R. Day, Susan M. Noworolski, Joshua M. Star-Lack, Lawrence L. Wald, William P. Dillon, Susan M. Chang, Sarah J. Nelson
American Journal of Neuroradiology Feb 2000, 21 (2) 357-366;

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Comparison of Relative Cerebral Blood Volume and Proton Spectroscopy in Patients with Treated Gliomas
Roland G. Henry, Daniel B. Vigneron, Nancy J. Fischbein, P. Ellen Grant, Mark R. Day, Susan M. Noworolski, Joshua M. Star-Lack, Lawrence L. Wald, William P. Dillon, Susan M. Chang, Sarah J. Nelson
American Journal of Neuroradiology Feb 2000, 21 (2) 357-366;
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  • Differentiation between Oligodendroglioma Genotypes Using Dynamic Susceptibility Contrast Perfusion-Weighted Imaging and Proton MR Spectroscopy
  • Imaging biomarkers of brain tumour margin and tumour invasion
  • Correlation of MR Relative Cerebral Blood Volume Measurements with Cellular Density and Proliferation in High-Grade Gliomas: An Image-Guided Biopsy Study
  • Distinction between pyogenic brain abscess and necrotic brain tumour using 3-tesla MR spectroscopy, diffusion and perfusion imaging
  • Role of Perfusion CT in Glioma Grading and Comparison with Conventional MR Imaging Features
  • Arterial Spin-Labeling and MR Spectroscopy in the Differentiation of Gliomas
  • Analysis of Metabolic Indices in Regions of Abnormal Perfusion in Patients with High-Grade Glioma
  • Metabolic Findings on 3T 1H-MR Spectroscopy in Peritumoral Brain Edema
  • Diagnosis and Treatment of Recurrent High-Grade Astrocytoma
  • Update on Brain Tumor Imaging: From Anatomy to Physiology
  • Dynamic Susceptibility-Weighted Perfusion Imaging of High-Grade Gliomas: Characterization of Spatial Heterogeneity
  • MR Cerebral Blood Volume Maps Correlated with Vascular Endothelial Growth Factor Expression and Tumor Grade in Nonenhancing Gliomas
  • Relationship of MR-Derived Lactate, Mobile Lipids, and Relative Blood Volume for Gliomas in Vivo
  • Dynamic Magnetic Resonance Perfusion Imaging of Brain Tumors
  • Glioma Grading: Sensitivity, Specificity, and Predictive Values of Perfusion MR Imaging and Proton MR Spectroscopic Imaging Compared with Conventional MR Imaging
  • Blood Volume of Gliomas Determined by Double-Echo Dynamic Perfusion-Weighted MR Imaging: A Preliminary Study
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