Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • For Authors
  • About Us
    • About AJNR
    • Editors
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Other Publications
    • ajnr

User menu

  • Subscribe
  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

  • Subscribe
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • For Authors
  • About Us
    • About AJNR
    • Editors
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds
LetterOTHER CONTENT

In Re: Radiologic and Histopathologic Evaluation of Canine Artery Occlusion After Collagen-Coated Platinum Microcoil Delivery

Guido Guglielmi
American Journal of Neuroradiology March 2000, 21 (3) 607;
Guido Guglielmi
aUniversity of Rome Medical School Department of Neurosciences Rome, Italy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • References
  • PDF
Loading

I read with interest, in the April 1999 issue of AJNR, the article of Tamatani and colleagues (1) on the evaluation of endovascular collagen-coated coils in the experimental setting, and the relative editorial of Berenstein on future developments of coils for aneurysms (2). In our field of endovascular neurosurgery, we all have seen in recent years many experimental articles dealing with surface modifications of coils, collagen added to coils, coatings added to coils, etc. The appropriate references are all in the thorough and articulate article of Tamatani and colleagues (1).

I would like to comment on the sentence of Dr. Berenstein: “The delivery of coated or biologically altered coils into the aneurysmal lumen seems to be a promising method for producing intravascular scars, and may represent a revolution in the management of presently unmanageable lesions.” I sincerely hope that Dr. Berenstein is right. We have to consider, however, that regular GDCs, because of their malleability and elasticity, may partially absorb the pulsatile energy of the blood circulation by damping the acute spike of the systole and gradually redistributing the systolic energy to the entire wall of the aneurysm. In other words, coils may act as the shoreline that transforms the waves of the sea into a continuous motion of the water. I cannot imagine any other explanation for why, as Dr. Berenstein suggests, even subtotally coiled aneurysms have a low (re)bleeding rate. If this is true, then the fact that GDCs do not induce a “scar” would be a “good thing.” I do not know if an intra-aneurysmal scar would improve aneurysm healing or would act as a hammer toward any residual portion of the aneurysm. A scar could induce retraction of the walls of the parent vessel with consequent stenosis. Unlike coiling or clipping, a scar could offer a wide, stiff surface to the systole with unknown effects on the parent artery and on any residuum of the aneurysm. One thing is certain—with an intra-aneurysmal scar, we would lose forever the shock-absorbing effect of the coils. In any event, experimental aneurysms are so different from their human counterpart that any extrapolation of medium long-term results would be inaccurate. As often happens in science, there was some casualty and luck in 1989–1990 when our experimental work (that led to the GDCs) was also successful in patients. I do not intend to dampen the enthusiasm of clinicians who aim to change GDCs with bioactive materials in order to obtain a more stable aneurysm occlusion. Nevertheless we will have to be very cautious in expanding experimental findings beyond their boundaries.

References

  1. ↵
    Tamatani S, Ozawa T, Minakawa T, Takeuchi S, Koike T, Tanaka R. Radiologic and histopathologic evaluation of canine artery occlusion after collagen-coated platinum microcoil delivery. AJNR Am J Neuroradiol 1999;20:541-545
    Abstract/FREE Full Text
  2. ↵
    Berenstein A. Tissue response to Guglielmi detachable coils: present implications and future developments. Editorial. AJNR Am J Neuroradiol 1999;20:533-534
    FREE Full Text
  • Copyright © American Society of Neuroradiology
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology
Vol. 21, Issue 3
1 Mar 2000
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
In Re: Radiologic and Histopathologic Evaluation of Canine Artery Occlusion After Collagen-Coated Platinum Microcoil Delivery
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
In Re: Radiologic and Histopathologic Evaluation of Canine Artery Occlusion After Collagen-Coated Platinum Microcoil Delivery
Guido Guglielmi
American Journal of Neuroradiology Mar 2000, 21 (3) 607;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
In Re: Radiologic and Histopathologic Evaluation of Canine Artery Occlusion After Collagen-Coated Platinum Microcoil Delivery
Guido Guglielmi
American Journal of Neuroradiology Mar 2000, 21 (3) 607;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • References
  • Info & Metrics
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Dr Doppman: The Lone Radiologist
  • Emergency Interventional Stroke Therapy: A Statement from the American Society of Interventional and Therapeutic Neuroradiology  Stroke Task Force of the American Society of Neuroradiology and The Society of Cardiovascular and Interventional Radiology
  • Biography: Wade Wong, Sixth President of the American Society of Spine Radiology
Show more OTHER CONTENT

Similar Articles

Advertisement

News and Updates

  • Lucien Levy Best Research Article Award
  • Thanks to our 2021 Distinguished Reviewers
  • Press Releases

Resources

  • Evidence-Based Medicine Level Guide
  • How to Participate in a Tweet Chat
  • AJNR Podcast Archive
  • Ideas for Publicizing Your Research
  • Librarian Resources
  • Terms and Conditions

Opportunities

  • Share Your Art in Perspectives
  • Get Peer Review Credit from Publons
  • Moderate a Tweet Chat

American Society of Neuroradiology

  • Neurographics
  • ASNR Annual Meeting
  • Fellowship Portal
  • Position Statements

© 2022 by the American Society of Neuroradiology | Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire