Research ArticlePEDIATRICS
X-linked Adrenoleukodystrophy: The Role of Contrast-enhanced MR Imaging in Predicting Disease Progression
Elias R. Melhem, Daniel J. Loes, Christos S. Georgiades, Gerald V. Raymond and Hugo W. Moser
American Journal of Neuroradiology May 2000, 21 (5) 839-844;
Elias R. Melhem
Daniel J. Loes
Christos S. Georgiades
Gerald V. Raymond
References
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- Singh I, Moser AB, Goldfischer S, et al. Lignoceric acid is oxidized in the peroxisomes: implications for the Zellweger cerebro-hepato-renal syndrome and adrenoleuko-dystrophy. Proc Natl Acad Sci U S A 1984;81:4203-4207
- Laxo O, Contreras M, Hashmi M, et al. Peroxisomal lignoceroyl-CoA ligase deficiency in childhood adrenoleukodystrohy and adrenomyeloneuropathy. Proc Natl Acad Sci U S A 1988;85:7647-7651
- ↵Migeon BR, Moser HW, Moser AB, et al. Adrneoleukodystrophy: evidence for X-linkage, inactivation and selection favoring the mutant allele in heterozygous cells. Proc Natl Acad Sci U S A 1981; 78:5066-5070
- Bezman L, Moser HW. The incidence of X-linked adrenoleukodystrophy and the relative frequency of its phenotypes. Am J Med Genet 1998;76:415-419
- Moser HW. Adrenoleukodystrophy: phenotype, genetics, pathogenesis and therapy. Brain 1997;120:1485-1508
- ↵Smith KD, Kemp S, Braiterman LT, et al. X-linked adrenoleukodystrophy: genes, mutations, and phenotypes. Neurochem Res 1999;24:511-525
- Singh I, Moser AB, Moser HW, et al. Adrenoleukodystrophy: impaired oxidation of VLCF in white blood cells, cultured skin fibroblasts and amniocytes. Pediatr Res 1984;18:286-290
- ↵Wanders RJA, van Roermund CWT, Lageweg W, et al. X-linked adrenoleuko-dystrophy: biochemical diagnosis and enzyme defect. J Inherit Metab Dis 1992;15:634-644
- ↵Schaumburg HH, Powers JM, Raine CS, et al. Adrenoleukodystrophy: a clinical and pathological study of 17 cases. Arch Neurol 1975;33:577-591
- ↵Powers J, Liu Y, Moser AB, et al. The inflammatory myelinopathy of adrenoleuko-dystrophy: cells, effector molecules, and pathogenetic implications. J Neuropathol Exp Neurol 1992;51:630-643
- ↵Melhem ER, Breiter SN, Ulug AM, Raymond GV, Moser HW. Improved tissue characterization in adrenoleukodystrophy using magnetization transfer imaging. AJR Am J Roentgenol 1996;166:689-695
- ↵Loes DJ, Hite S, Moser HW, et al. Adrenoleukodystrophy: a scoring method for brain MR observation. AJNR Am J Neuroradiol 1994;15:1761-1766
- ↵Krivit W, Lockman LA, Watkins PA, et al. The future for treatment by bone marrow transplantation for adrenoleukodystrophy, metachromatic leukodystrophy, globid cell leukodystrophy and Hurler syndrome. J Inherit Metab Dis 1995;18:398-412
- ↵Powers JM. The pathology of peroxisomal disorders with pathogenetic considerations. J Neuropathol Exp Neurol 1994;54:710-719
- Tzika AA, Ball WS Jr, Vigneron DB, et al. Childhood adrenoleukodystrophy: assessment with proton MR spectroscopy. Radiology 1993;189:467-480
- Kruse B, Barker PB, van Zijl PCM, et al. Multislice proton MR spectroscopic imaging in X-linked adrenoleukodystrophy. Ann Neurol 1994;36:595-608
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X-linked Adrenoleukodystrophy: The Role of Contrast-enhanced MR Imaging in Predicting Disease Progression
Elias R. Melhem, Daniel J. Loes, Christos S. Georgiades, Gerald V. Raymond, Hugo W. Moser
American Journal of Neuroradiology May 2000, 21 (5) 839-844;
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