Abstract
BACKGROUND AND PURPOSE: In subjects who are performing no prescribed cognitive task, functional connectivity mapped with MR imaging (fcMRI) shows regions with synchronous fluctuations of cerebral blood flow. When specific tasks are performed, functional MR imaging (fMRI) can map locations in which regional cerebral blood flow increases synchronously with the performance of the task. We tested the hypothesis that fcMRI maps, based on the synchrony of low-frequency blood flow fluctuations, identify brain regions that show activation on fMRI maps of sensorimotor, visual, language, and auditory tasks.
METHODS: In four volunteers, task-activation fMRI and functional connectivity (resting-state) fcMRI data were acquired. A small region of interest (in an area that showed maximal task activation) was chosen, and the correlation coefficient of the corresponding resting-state signal with the signal of all other voxels in the resting data set was calculated. The correlation coefficient was decomposed into frequency components and its distribution determined for each fcMRI map. The fcMRI maps were compared with the fMRI maps.
RESULTS: For each task, fcMRI maps based on one to four seed voxel(s) produced clusters of voxels in regions of eloquent cortex. For each fMRI map a closely corresponding fcMRI map was obtained. The frequencies that predominated in the cross-correlation coefficients for the functionally related regions were below 0.1 Hz.
CONCLUSION: Functionally related brain regions can be identified by means of their synchronous slow fluctuations in signal intensity. Such blood flow synchrony can be detected in sensorimotor areas, expressive and receptive language regions, and the visual cortex by fcMRI. Regions identified by the slow synchronous fluctuations are similar to those activated by motor, language, or visual tasks.
- Copyright © American Society of Neuroradiology
In this issue
Jump to section
Related Articles
Cited By...
- Trait-like variants in human functional brain networks
- Resting-State Functional Networks of Different Topographic Representations in the Somatosensory Cortex of Macaque Monkeys and Humans
- MOU-EC: model-based whole-brain effective connectivity to extract biomarkers for brain dynamics from fMRI data and study distributed cognition
- The Relationship between BOLD and Neural Activity Arises from Temporally Sparse Events
- Large-scale intrinsic connectivity is consistent across varying task demands
- Extracting orthogonal subject- and behavior-specific signatures from fMRI data using whole-brain effective connectivity
- Analysis of fMRI data using noise-diffusion network models: a new covariance-coding perspective
- Stereotypical modulations in dynamic functional connectivity explained by changes in BOLD variance
- Effective connectivity inferred from fMRI transition dynamics during movie viewing points to a balanced reconfiguration of cortical interactions
- Resting State Networks in empirical and simulated dynamic functional connectivity
- Impact of gray matter signal regression in resting state and language task functional networks
- State-dependent modulation of functional connectivity in early blind individuals
- High spatial correspondence at a columnar level between activation and resting state fMRI signals and local field potentials
- Brain Age: A State-Of-Mind? On the Stability of Functional Connectivity across Behavioral States
- Functional connectivity arises from a slow rhythmic mechanism
- Imperceptible Somatosensory Stimulation Alters Sensorimotor Background Rhythm and Connectivity
- Noninvasive Functional and Anatomical Imaging of the Human Medial Temporal Lobe
- Intrinsically organized resting state networks in the human spinal cord
- Low-frequency calcium oscillations accompany deoxyhemoglobin oscillations in rat somatosensory cortex
- Time-varying functional network information extracted from brief instances of spontaneous brain activity
- Reorganization of Functional Connectivity of the Language Network in Patients with Brain Gliomas
- Unravelling the Intrinsic Functional Organization of the Human Lateral Frontal Cortex: A Parcellation Scheme Based on Resting State fMRI
- Functional Connectivity during Resting-State Functional MR Imaging: Study of the Correspondence between Independent Component Analysis and Region-of-Interest-Based Methods
- Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI
- Global Functional Connectivity Deficits in Schizophrenia Depend on Behavioral State
- Comparison of Hypothesis- and a Novel Hybrid Data/Hypothesis-Driven Method of Functional MR Imaging Analysis in Patients with Brain Gliomas
- Functional Connectivity MR Imaging of the Language Network in Patients with Drug-Resistant Epilepsy
- Growing Together and Growing Apart: Regional and Sex Differences in the Lifespan Developmental Trajectories of Functional Homotopy
- Neural basis of global resting-state fMRI activity
- Investigating the Functional Heterogeneity of the Default Mode Network Using Coordinate-Based Meta-Analytic Modeling
- Correspondence of the brain's functional architecture during activation and rest
- Decoupling of the brain's default mode network during deep sleep
- Distinct Cerebellar Contributions to Intrinsic Connectivity Networks
- The Blood Oxygen Level-Dependent Functional MR Imaging Signal Can Be Used to Identify Brain Tumors and Distinguish Them from Normal Tissue
- Regional Variation in Interhemispheric Coordination of Intrinsic Hemodynamic Fluctuations
- Functional Connectivity MR Imaging Reveals Cortical Functional Connectivity in the Developing Brain
- Origin of Synchronized Low-Frequency Blood Oxygen Level-Dependent Fluctuations in the Primary Visual Cortex
- Resting-state networks in the infant brain
- Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control
- Consistent resting-state networks across healthy subjects
- Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems
- From The Cover: The human brain is intrinsically organized into dynamic, anticorrelated functional networks
- Role of the Corpus Callosum in Functional Connectivity
- Frequencies Contributing to Functional Connectivity in the Cerebral Cortex in ""Resting-state"" Data
- Effect of Focal and Nonfocal Cerebral Lesions on Functional Connectivity Studied with MR Imaging