Abstract
BACKGROUND AND PURPOSE: Knowledge of cerebral blood flow (CBF) alterations in cases of acute stroke could be valuable in the early management of these cases. Among imaging techniques affording evaluation of cerebral perfusion, perfusion CT studies involve sequential acquisition of cerebral CT sections obtained in an axial mode during the IV administration of iodinated contrast material. They are thus very easy to perform in emergency settings. Perfusion CT values of CBF have proved to be accurate in animals, and perfusion CT affords plausible values in humans. The purpose of this study was to validate perfusion CT studies of CBF by comparison with the results provided by stable xenon CT, which have been reported to be accurate, and to evaluate acquisition and processing modalities of CT data, notably the possible deconvolution methods and the selection of the reference artery.
METHODS: Twelve stable xenon CT and perfusion CT cerebral examinations were performed within an interval of a few minutes in patients with various cerebrovascular diseases. CBF maps were obtained from perfusion CT data by deconvolution using singular value decomposition and least mean square methods. The CBF were compared with the stable xenon CT results in multiple regions of interest through linear regression analysis and bilateral t tests for matched variables.
RESULTS: Linear regression analysis showed good correlation between perfusion CT and stable xenon CT CBF values (singular value decomposition method: R2 = 0.79, slope = 0.87; least mean square method: R2 = 0.67, slope = 0.83). Bilateral t tests for matched variables did not identify a significant difference between the two imaging methods (P > .1). Both deconvolution methods were equivalent (P > .1). The choice of the reference artery is a major concern and has a strong influence on the final perfusion CT CBF map.
CONCLUSION: Perfusion CT studies of CBF achieved with adequate acquisition parameters and processing lead to accurate and reliable results.
- Copyright © American Society of Neuroradiology
In this issue
Jump to section
Related Articles
Cited By...
- Comparison of Perfusion CT Software to Predict the Final Infarct Volume After Thrombectomy
- Cerebral Perfusion Pressure is Maintained in Acute Intracerebral Hemorrhage: A CT Perfusion Study
- Effects of Induced Hypertension on Cerebral Perfusion in Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: A Randomized Clinical Trial
- Imaging Evidence and Recommendations for Traumatic Brain Injury: Advanced Neuro- and Neurovascular Imaging Techniques
- Computed Tomography Workup of Patients Suspected of Acute Ischemic Stroke: Perfusion Computed Tomography Adds Value Compared With Clinical Evaluation, Noncontrast Computed Tomography, and Computed Tomography Angiogram in Terms of Predicting Outcome
- Use of neuroimaging to guide the treatment of patients beyond the 8-hour time window
- Effect of Stenting on Cerebral CT Perfusion in Symptomatic and Asymptomatic Patients with Carotid Artery Stenosis
- Correlation between cerebral blood flow and oxygen saturation in patients with subarachnoid hemorrhage and traumatic brain injury
- In Vivo Evaluation of Quantitative MR Angiography in a Canine Carotid Artery Stenosis Model
- Increased Blood-Brain Barrier Permeability on Perfusion CT Might Predict Malignant Middle Cerebral Artery Infarction
- Perfusion CT in Acute Ischemic Stroke: A Qualitative and Quantitative Comparison of Deconvolution and Maximum Slope Approach
- Diagnostic Threshold Values of Cerebral Perfusion Measured With Computed Tomography for Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage
- Acute Hydrocephalus and Cerebral Perfusion after Aneurysmal Subarachnoid Hemorrhage
- Recommendations for Imaging of Acute Ischemic Stroke: A Scientific Statement From the American Heart Association
- Diagnosing Delayed Cerebral Ischemia With Different CT Modalities in Patients With Subarachnoid Hemorrhage With Clinical Deterioration
- Theoretic Basis and Technical Implementations of CT Perfusion in Acute Ischemic Stroke, Part 1: Theoretic Basis
- Tracer Delay-Insensitive Algorithm Can Improve Reliability of CT Perfusion Imaging for Cerebrovascular Steno-Occlusive Disease: Comparison with Quantitative Single-Photon Emission CT
- CT Perfusion Quantification of Small-Vessel Ischemic Severity
- Sixty-Four-Section CT Cerebral Perfusion Evaluation in Patients with Carotid Artery Stenosis before and after Stenting with a Cerebral Protection Device
- Role of Perfusion CT in Glioma Grading and Comparison with Conventional MR Imaging Features
- Regional Cerebral Blood Flow Using Quantitative MR Angiography
- Reproducibility of Quantitative CT Brain Perfusion Measurements in Patients with Symptomatic Unilateral Carotid Artery Stenosis
- Identification of the penumbra and infarct core on hyperacute noncontrast and perfusion CT
- Dynamic CT Perfusion Imaging with Acetazolamide Challenge for Evaluation of Patients with Unilateral Cerebrovascular Steno-Occlusive Disease
- Identification of Penumbra and Infarct in Acute Ischemic Stroke Using Computed Tomography Perfusion-Derived Blood Flow and Blood Volume Measurements
- CT after subarachnoid hemorrhage: Relation of cerebral perfusion to delayed cerebral ischemia
- Visual evaluation of perfusion computed tomography in acute stroke accurately estimates infarct volume and tissue viability
- Prognostic Value of Cerebral Perfusion-Computed Tomography in the Acute Stage After Subarachnoid Hemorrhage for the Development of Delayed Cerebral Ischemia
- Vasospasm after Subarachnoid Hemorrhage: Utility of Perfusion CT and CT Angiography on Diagnosis and Management
- Influence of Partial Volume on Venous Output and Arterial Input Function
- Correlation between initial and early follow-up CT perfusion parameters with endoscopic tumor response in patients with advanced squamous cell carcinomas of the oropharynx treated with organ-preservation therapy.
- Effects of Carotid or Vertebrobasilar Stent Placement on Cerebral Perfusion and Cognition
- Relationship between Brain Tissue Oxygen Tension and CT Perfusion: Feasibility and Initial Results
- Perfusion CT for Head and Neck Tumors: Pilot Study
- Accuracy of Dynamic Perfusion CT with Deconvolution in Detecting Acute Hemispheric Stroke
- Brain imaging using multislice CT: a personal perspective
- CT Perfusion Parameter Values in Regions of Diffusion Abnormalities
- Brain Perfusion in Children: Evolution With Age Assessed by Quantitative Perfusion Computed Tomography
- Dynamic Perfusion CT: Optimizing the Temporal Resolution and Contrast Volume for Calculation of Perfusion CT Parameters in Stroke Patients
- Prediction of Neurologic Deterioration in Patients with Lacunar Infarction in the Territory of the Lenticulostriate Artery Using Perfusion CT
- Cerebral perfusion and stroke
- Perfusion CT for the assessment of tumour vascularity: which protocol?
- Correlation of Early Dynamic CT Perfusion Imaging with Whole-Brain MR Diffusion and Perfusion Imaging in Acute Hemispheric Stroke
- Guidelines for the Early Management of Patients With Ischemic Stroke: A Scientific Statement From the Stroke Council of the American Stroke Association
- Perfusion CT: a worthwhile enhancement?
- Guidelines and Recommendations for Perfusion Imaging in Cerebral Ischemia: A Scientific Statement for Healthcare Professionals by the Writing Group on Perfusion Imaging, From the Council on Cardiovascular Radiology of the American Heart Association
- Comparison of Admission Perfusion Computed Tomography and Qualitative Diffusion- and Perfusion-Weighted Magnetic Resonance Imaging in Acute Stroke Patients
- CT Perfusion Flow Assessment: "Up and Coming" or "Off and Running"?