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Neurotoxicity of Intrathecal Methotrexate: MR Imaging Findings

Claudio Sandoval, Martin Kutscher, Somasundaram Jayabose and Michael Tenner
American Journal of Neuroradiology October 2003, 24 (9) 1887-1890;
Claudio Sandoval
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Martin Kutscher
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Somasundaram Jayabose
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Michael Tenner
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References

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    Haskell CM, Rosen L. Antineoplastic agents. In: Haskell CM, ed. Cancer Treatment. 5th ed. Philadelphia: Saunders;2001 :176–181
  2. ↵
    Mahoney DH, Shuster JJ, Nitschke R, et al. Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy: a Pediatric Oncology Group study. J Clin Oncol 1998;16:1712–1722
    Abstract
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    Lo Nigro L, Di Cataldo A, Schiliro G. Acute neurotoxicity in children with B-lineage acute lymphoblastic leukemia (B-ALL) treated with intermediate risk protocols. Med Pediatr Oncol 2000;35:449–455
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    Drachtman RA, Cole PD, Golden CB, et al. Dextromethorphan is effective in the treatment of subacute methotrexate neurotoxicity. Pediatr Hematol Oncol 2002;19:319–327
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    Quinn CT, Griener JC, Bottiglieri T, et al. Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer. J Clin Oncol 1997;15:2800–2806
    Abstract
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    Davidson A, Payne G, Leach MO, et al. Proton magnetic resonance spectroscopy ([1]H-MRS) of the brain following high-dose methotrexate treatment for childhood cancer. Med Pediatr Oncol 2000;35:28–34
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    Osterlundh G, Bjure J, Lannering B, et al. Studies of cerebral blood flow in children with acute lymphoblastic leukemia: case reports of six children treated with methotrexate examined by single photon emission computed tomography. J Pediatr Hematol Oncol 1997;19:28–34
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    Harila-Saari AH, Ahonen AK, Vainionpaa LK, et al. Brain perfusion after treatment of childhood acute lymphoblastic leukemia. J Nucl Med 1997;38:82–88
    Abstract/FREE Full Text
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    Karabacak NI, Ozturk G, Gucuyener K, et al. Assessment of brain perfusion by 99m Tc-HMPAO SPECT in akinetic mutism due to high-dose intravenous methotrexate therapy. Childs Nerv Syst 1997;13:560–562
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American Journal of Neuroradiology: 24 (9)
American Journal of Neuroradiology
Vol. 24, Issue 9
1 Oct 2003
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Neurotoxicity of Intrathecal Methotrexate: MR Imaging Findings
Claudio Sandoval, Martin Kutscher, Somasundaram Jayabose, Michael Tenner
American Journal of Neuroradiology Oct 2003, 24 (9) 1887-1890;

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Neurotoxicity of Intrathecal Methotrexate: MR Imaging Findings
Claudio Sandoval, Martin Kutscher, Somasundaram Jayabose, Michael Tenner
American Journal of Neuroradiology Oct 2003, 24 (9) 1887-1890;
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