Research ArticlePEDIATRICS
Prevalence of Leukoencephalopathy in Children Treated for Acute Lymphoblastic Leukemia with High-Dose Methotrexate
Wilburn E. Reddick, John O. Glass, Kathleen J. Helton, James W. Langston, Xiaoping Xiong, Shengjie Wu and Ching-Hon Pui
American Journal of Neuroradiology May 2005, 26 (5) 1263-1269;
Wilburn E. Reddick
John O. Glass
Kathleen J. Helton
James W. Langston
Xiaoping Xiong
Shengjie Wu
References
- ↵Pui C-H, Relling MV, Downing JR. Mechanisms of disease acute lymphoblastic leukemia. N Engl J Med 2004;350:1535–1548
- ↵Shuper A, Stark B, Kornreich L, Cohen IJ, Avrahami G, Yaniv I. Methotrexate-related neurotoxicity in the treatment of childhood acute lymphoblastic leukemia. Isr Med Assoc J 2002;4:1050–1053
- ↵McIntosh S, Fischer DB, Rothman SG, Rosenfield N, Lobel JS, O’Brien RT. Intracranial calcifications in childhood leukemia. J Pediatr 1977;91:909–913
- Peylan-Ramu N, Poplack DG, Pizzo PA, Adornato BT, Di Chiro G. Abnormal CT scans of the brain in asymptomatic children with acute lymphocytic leukemia after prophylactic treatment of the central nervous system with radiation and intrathecal chemotherapy. N Engl J Med 1978;298:815–818
- ↵Ochs JJ, Parvey LS, Whitaker JN, et al. Serial cranial computed-tomography scans in children with leukemia given two different forms of central nervous system therapy. J Clin Oncol 1983;1:793–798
- Brouwers P, Poplack DG. Memory and learning sequelae in long-term survivors of acute lymphoblastic leukemia: association with attention deficits. Am J Pediatr Hematol Oncol 1990;12:174–181
- ↵Ochs JJ, Mulhern RK, Fairclough D, et al. Comparison of neuropsychologic functioning and clinical indicators of neurotoxicity in long-term survivors of childhood leukemia given cranial radiation or parenteral methotrexate: a prospective study. J Clin Oncol 1991;9:145–151
- ↵Paakko E, Vainionpaa L, Lanning M, Laitinen J, Pyhtinen J. White matter changes in children treated for acute lymphoblastic leukemia. Cancer 1992;70:2728–2733
- Kingma A, Mooyaart EL, Kamps WA, Nieuwenhuizen P, Wilmink JT. Magnetic resonance imaging of the brain and neuropsychological evaluation in children treated for acute lymphoblastic leukemia at a young age. Am J Pediatr Hematol Oncol 1993;15:231–238
- ↵Paakko E, Vainionpaa L, Pyhtinen J, Lanning M. Minor changes on cranial MRI during treatment in children with acute lymphoblastic leukemia. Neuroradiology 1996;38:264–268
- Hertzburg H, Huk WJ, Ueberall MA, et al. CNS late effects after ALL therapy in childhood, part 1: neuroradiological findings in long-term survivors of childhood ALL—an evaluation of the interferences between morphology and neuropsychological performance. Med Pediatr Oncol 1997;28:387–400
- Paakko E, Harila-Saari A, Vanionpaa L, Himanen S, Pyhtinen J, Lanning M. White matter changes on MRI during treatment in children with acute lymphoblastic leukemia: correlation with neuropsychological findings. Med Pediatr Oncol 2000;35:456–461
- Kingma A, van Dommelen RI, Mooyaart EL, Wilmink JT, Deelman BG, Kamps WA. Slight cognitive impairment and magnetic resonance imaging abnormalities but normal school levels in children treated for acute lymphoblastic leukemia with chemotherapy only. J Pediatr 2001;139:413–420
- ↵Chu WCW, Chik KW, Chan YL, et al. White matter and cerebral metabolite changes in children undergoing treatment for acute lymphoblastic leukemia: longitudinal study with MR imaging and 1H MR spectroscopy. Radiology 2003;229:659–669
- ↵Wilson DA, Nitschke R, Bowman ME, Chaffin MJ, Sexauer CL, Prince JR. Transient white matter changes on MR images in children undergoing chemotherapy for acute lymphocytic leukemia: correlation with neuropsychologic deficiencies. Radiology 1991;180:205–209
- ↵Asato R, Akiyama Y, Ito M, et al. Nuclear magnetic resonance abnormalities of the cerebral white matter in children with acute lymphoblastic leukemia and malignant lymphoma during and after central nervous system prophylactic treatment with intrathecal methotrexate. Cancer 1992;70:1997–2004
- ↵Mahoney DH Jr, Shuster JJ, Nitschke R, et al. Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy—a pediatric oncology group study. J Clin Oncol 1998;16:1712–1722
- ↵Evans WE, Relling MV, Rodman JH, Crom WR, Boyett JM, Pui CH. Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia. N Engl J Med 1998;338:499–505
- ↵Ostuni JL, Levin RL, Frank JA, DeCarli C. Correspondence of closest gradient voxels: a robust registration algorithm. J Magn Reson Imaging 1997;7:410–15
- ↵Reddick WE, Glass JO, Cook EN, Elkin TD, Deaton R. Automated segmentation and classification of multispectral magnetic resonance images of brain using artifical neural networks. IEEE Trans Med Imaging 1997;16:911–918
- ↵Reddick WE, Glass JO, Langston JW, Helton KJ. Quantitative MRI assessment of leukoencephalopathy. Magn Reson Med 2002;47:912–920
- ↵
- ↵Reddick WE, Glass JO, Pui CH. Differentiating therapy-indeed leukoencephalopathy from unmyelinated white matter in children treated for acute lymphoblastic leukemia (ALL). Presented at the 11th Scientific Meeting, International Society of Magnetic Resonance in Medicine, Toronto, Ontario, Canada, July,2003
In this issue
Advertisement
Prevalence of Leukoencephalopathy in Children Treated for Acute Lymphoblastic Leukemia with High-Dose Methotrexate
Wilburn E. Reddick, John O. Glass, Kathleen J. Helton, James W. Langston, Xiaoping Xiong, Shengjie Wu, Ching-Hon Pui
American Journal of Neuroradiology May 2005, 26 (5) 1263-1269;
Jump to section
Related Articles
- No related articles found.
Cited By...
- The Impact of Persistent Leukoencephalopathy on Brain White Matter Microstructure in Long-Term Survivors of Acute Lymphoblastic Leukemia Treated with Chemotherapy Only
- Methotrexate-Induced Neurotoxicity and Leukoencephalopathy in Childhood Acute Lymphoblastic Leukemia
- Voxel-Based Analysis of T2 Hyperintensities in White Matter during Treatment of Childhood Leukemia
- High-dose compared with intermediate-dose methotrexate in children with a first relapse of acute lymphoblastic leukemia
This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.
More in this TOC Section
Similar Articles
Advertisement