Article Figures & Data
Figures
- Fig 1.
Number 3 aneurysm in Matrix group, 2-week implant.
A, Anteroposterior DSA of the brachiocephalic artery shows a moderately wide-necked aneurysm.
B, Anteroposterior DSA obtained immediately after embolization with Matrix coils shows near-complete occlusion of the aneurysm.
C, Anteroposterior DSA obtained 2 weeks after embolization shows marked coil compaction.
D, Hematoxylin and eosin stain; original magnification, ×1.5. Coronal section obtained through the aneurysm cavity. Microcompaction and inflammation along neck are shown.
E, Hematoxylin and eosin stain; original magnification, ×25. Magnification of the area shown in panel D; substantial inflammation is shown along neck.
- Fig 2.
Number 9 aneurysm in Matrix group, 10-week implant.
A, Anteroposterior DSA of the brachiocephalic artery shows a wide-necked aneurysm.
B, Anteroposterior DSA obtained immediately after embolization with Matrix coils shows the aneurysm is nearly completely occluded.
C, Anteroposterior DSA obtained 2 weeks after embolization shows slight coil compaction.
D, Hematoxylin and eosin stain; original magnification, ×1.3. Coronal section obtained through the aneurysm cavity. Marked microcompaction and unorganized thrombus are shown. There is no tissue across the aneurysm neck.
E, Hematoxylin and eosin stain; original magnification, ×25. Magnification of the area shown in panel D. Dense cellular infiltration near coils in the dome is seen.
- Fig 3.
Number 15 aneurysm in HydroCoil group, 6-week implant.
A, Anteroposterior DSA of the brachiocephalic artery shows a wide-necked aneurysm.
B, Anteroposterior DSA obtained immediately after embolization with HydroCoils shows the aneurysm is nearly completely occluded.
C, Anteroposterior DSA obtained 2 weeks after embolization shows the aneurysm remaining stable.
D, Hematoxylin and eosin stain; original magnification, ×1.1. Coronal section obtained through the aneurysm cavity. No substantial inflammatory response is present. Microcompaction is absent. A small part of persistent unorganized thrombus is shown in the aneurysm dome.
E, Hematoxylin and eosin stain; original magnification, ×10. Magnification of the area shown in panel D. Cellular fibrous tissue is shown across the neck.
Tables
Group Time Point AneurysmWidth (mm) AneurysmLength (mm) AneurysmNeck (mm) AneurysmVolume (cm3) HydroCoil 2 weeks 4.3 ± 0.6 9.0 ± 1.7 3.0 ± 1.0 0.14 ± 0.07 HydroCoil 6 weeks 4.8 ± 0.3 7.5 ± 2.5 4.3 ± 0.6 0.14 ± 0.06 HydroCoil 10 weeks 4.0 ± 1.0 6.7 ± 3.0 2.0 ± 1.0 0.10 ± 0.09 HydroCoil All 4.4 ± 0.7 8.2 ± 3.1 3.1 ± 1.3 0.12 ± 0.06 Pt Coil 2 weeks 4.2 ± 0.8 10.2 ± 1.4 2.2 ± 0.3 0.15 ± 0.07 Pt Coil 6 weeks 4.7 ± 1.2 8.6 ± 2.3 3.5 ± 0.5 0.17 ± 0.13 Pt Coil 10 weeks 4.3 ± 0.6 6.3 ± 0.6 3.0 ± 0.6 0.10 ± 0.04 Pt Coil All 4.4 ± 0.8 8.4 ± 2.2 2.9 ± 0.7 0.13 ± 0.08 Matrix 2 weeks 4.3 ± 0.8 7.2 ± 2.2 2.9 ± 0.7 0.12 ± 0.06 Matrix 6 weeks 3.7 ± 0.8 6.9 ± 1.6 3.4 ± 0.7 0.08 ± 0.04 Matrix 10 weeks 4.6 ± 0.4 9.0 ± 1.0 5.5 ± 2.5 0.15 ± 0.04 Matrix All 4.2 ± 0.7 7.7 ± 1.8 3.9 ± 1.9 0.12 ± 0.06 Note.—Pt = platinum.
Group Time Point VolumetricFilling (%) DeviceLength (cm) Numberof Devices ProcedureTime (minutes) HydroCoil 2 weeks 48 ± 8 33 ± 14 4.3 ± 0.6 26 ± 6 HydroCoil 6 weeks 82 ± 16 44 ± 11 6.0 ± 2.0 29 ± 3 HydroCoil 10 weeks 97 ± 42 39 ± 15 5.7 ± 1.2 28 ± 5 HydroCoil All 76 ± 32 38 ± 13 5.3 ± 1.4 28 ± 4 Pt Coil 2 weeks 29 ± 8 53 ± 6 5.7 ± 1.2 28 ± 14 Pt Coil 6 weeks 31 ± 13 51 ± 19 6.0 ± 2.6 25 ± 11 Pt Coil 10 weeks 32 ± 8 51 ± 22 6.7 ± 3.1 28 ± 7 Pt Coil All 31 ± 9 52 ± 15 6.1 ± 2.1 27 ± 9 Matrix 2 weeks 22 ± 9 37 ± 13 3.2 ± 1.6 41 ± 12 Matrix 6 weeks 28 ± 6 35 ± 16 3.2 ± 1.3 19 ± 4 Matrix 10 weeks 19 ± 5 46 ± 11 5.2 ± 2.6 22 ± 10 Matrix All 23 ± 7 39 ± 14 3.9 ± 2.0 27 ± 13 Note.—Pt = platinum.
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