Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • For Authors
  • About Us
    • About AJNR
    • Editorial Board
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Other Publications
    • ajnr

User menu

  • Subscribe
  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

  • Subscribe
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • For Authors
  • About Us
    • About AJNR
    • Editorial Board
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds
Research ArticleINTERVENTIONAL

Angiographic and Histologic Analysis of Experimental Aneurysms Embolized with Platinum Coils, Matrix, and HydroCoil

Yong Hong Ding, Daying Dai, Debra A. Lewis, Harry J. Cloft and David F. Kallmes
American Journal of Neuroradiology August 2005, 26 (7) 1757-1763;
Yong Hong Ding
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daying Dai
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Debra A. Lewis
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Harry J. Cloft
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David F. Kallmes
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Fig 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 1.

    Number 3 aneurysm in Matrix group, 2-week implant.

    A, Anteroposterior DSA of the brachiocephalic artery shows a moderately wide-necked aneurysm.

    B, Anteroposterior DSA obtained immediately after embolization with Matrix coils shows near-complete occlusion of the aneurysm.

    C, Anteroposterior DSA obtained 2 weeks after embolization shows marked coil compaction.

    D, Hematoxylin and eosin stain; original magnification, ×1.5. Coronal section obtained through the aneurysm cavity. Microcompaction and inflammation along neck are shown.

    E, Hematoxylin and eosin stain; original magnification, ×25. Magnification of the area shown in panel D; substantial inflammation is shown along neck.

  • Fig 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 2.

    Number 9 aneurysm in Matrix group, 10-week implant.

    A, Anteroposterior DSA of the brachiocephalic artery shows a wide-necked aneurysm.

    B, Anteroposterior DSA obtained immediately after embolization with Matrix coils shows the aneurysm is nearly completely occluded.

    C, Anteroposterior DSA obtained 2 weeks after embolization shows slight coil compaction.

    D, Hematoxylin and eosin stain; original magnification, ×1.3. Coronal section obtained through the aneurysm cavity. Marked microcompaction and unorganized thrombus are shown. There is no tissue across the aneurysm neck.

    E, Hematoxylin and eosin stain; original magnification, ×25. Magnification of the area shown in panel D. Dense cellular infiltration near coils in the dome is seen.

  • Fig 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 3.

    Number 15 aneurysm in HydroCoil group, 6-week implant.

    A, Anteroposterior DSA of the brachiocephalic artery shows a wide-necked aneurysm.

    B, Anteroposterior DSA obtained immediately after embolization with HydroCoils shows the aneurysm is nearly completely occluded.

    C, Anteroposterior DSA obtained 2 weeks after embolization shows the aneurysm remaining stable.

    D, Hematoxylin and eosin stain; original magnification, ×1.1. Coronal section obtained through the aneurysm cavity. No substantial inflammatory response is present. Microcompaction is absent. A small part of persistent unorganized thrombus is shown in the aneurysm dome.

    E, Hematoxylin and eosin stain; original magnification, ×10. Magnification of the area shown in panel D. Cellular fibrous tissue is shown across the neck.

Tables

  • Figures
    • View popup
    TABLE 1:

    Pooled aneurysm data

    GroupTime PointAneurysmWidth (mm)AneurysmLength (mm)AneurysmNeck (mm)AneurysmVolume (cm3)
    HydroCoil2 weeks4.3 ± 0.69.0 ± 1.73.0 ± 1.00.14 ± 0.07
    HydroCoil6 weeks4.8 ± 0.37.5 ± 2.54.3 ± 0.60.14 ± 0.06
    HydroCoil10 weeks4.0 ± 1.06.7 ± 3.02.0 ± 1.00.10 ± 0.09
    HydroCoilAll4.4 ± 0.78.2 ± 3.13.1 ± 1.30.12 ± 0.06
    Pt Coil2 weeks4.2 ± 0.810.2 ± 1.42.2 ± 0.30.15 ± 0.07
    Pt Coil6 weeks4.7 ± 1.28.6 ± 2.33.5 ± 0.50.17 ± 0.13
    Pt Coil10 weeks4.3 ± 0.66.3 ± 0.63.0 ± 0.60.10 ± 0.04
    Pt CoilAll4.4 ± 0.88.4 ± 2.22.9 ± 0.70.13 ± 0.08
    Matrix2 weeks4.3 ± 0.87.2 ± 2.22.9 ± 0.70.12 ± 0.06
    Matrix6 weeks3.7 ± 0.86.9 ± 1.63.4 ± 0.70.08 ± 0.04
    Matrix10 weeks4.6 ± 0.49.0 ± 1.05.5 ± 2.50.15 ± 0.04
    MatrixAll4.2 ± 0.77.7 ± 1.83.9 ± 1.90.12 ± 0.06
    • Note.—Pt = platinum.

    • View popup
    TABLE 2:

    Pooled embolization results

    GroupTime PointVolumetricFilling (%)DeviceLength (cm)Numberof DevicesProcedureTime (minutes)
    HydroCoil2 weeks48 ± 833 ± 144.3 ± 0.626 ± 6
    HydroCoil6 weeks82 ± 1644 ± 116.0 ± 2.029 ± 3
    HydroCoil10 weeks97 ± 4239 ± 155.7 ± 1.228 ± 5
    HydroCoilAll76 ± 3238 ± 135.3 ± 1.428 ± 4
    Pt Coil2 weeks29 ± 853 ± 65.7 ± 1.228 ± 14
    Pt Coil6 weeks31 ± 1351 ± 196.0 ± 2.625 ± 11
    Pt Coil10 weeks32 ± 851 ± 226.7 ± 3.128 ± 7
    Pt CoilAll31 ± 952 ± 156.1 ± 2.127 ± 9
    Matrix2 weeks22 ± 937 ± 133.2 ± 1.641 ± 12
    Matrix6 weeks28 ± 635 ± 163.2 ± 1.319 ± 4
    Matrix10 weeks19 ± 546 ± 115.2 ± 2.622 ± 10
    MatrixAll23 ± 739 ± 143.9 ± 2.027 ± 13
    • Note.—Pt = platinum.

PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 26 (7)
American Journal of Neuroradiology
Vol. 26, Issue 7
1 Aug 2005
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Angiographic and Histologic Analysis of Experimental Aneurysms Embolized with Platinum Coils, Matrix, and HydroCoil
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
Citation Tools
Angiographic and Histologic Analysis of Experimental Aneurysms Embolized with Platinum Coils, Matrix, and HydroCoil
Yong Hong Ding, Daying Dai, Debra A. Lewis, Harry J. Cloft, David F. Kallmes
American Journal of Neuroradiology Aug 2005, 26 (7) 1757-1763;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Angiographic and Histologic Analysis of Experimental Aneurysms Embolized with Platinum Coils, Matrix, and HydroCoil
Yong Hong Ding, Daying Dai, Debra A. Lewis, Harry J. Cloft, David F. Kallmes
American Journal of Neuroradiology Aug 2005, 26 (7) 1757-1763;
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Methods
    • Aneurysm Creation
    • Description of Embolic Devices
    • Embolization Procedures
    • Follow-Up Procedures
    • Histologic Processing
    • Evaluation Criteria
    • Statistical Analysis
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

Related Articles

  • No related articles found.
  • Scopus
  • PubMed
  • Google Scholar

Cited By...

  • Assessment of endothelialization of aneurysm wall over time in a rabbit model through CD31 scoring
  • Rabbit aneurysm models mimic histologic wall types identified in human intracranial aneurysms
  • GEL THE NEC: a prospective registry evaluating the safety, ease of use, and efficacy of the HydroSoft coil as a finishing device
  • Testing Stenting and Flow Diversion Using a Surgical Elastase-Induced Complex Fusiform Aneurysm Model
  • From bench to bedside: utility of the rabbit elastase aneurysm model in preclinical studies of intracranial aneurysm treatment
  • HydroCoils Are Associated with Lower Angiographic Recurrence Rates Than Are Bare Platinum Coils in Treatment of "Difficult-to-Treat" Aneurysms: A Post Hoc Subgroup Analysis of the HELPS Trial
  • RNA-Sequencing Analysis of Messenger RNA/MicroRNA in a Rabbit Aneurysm Model Identifies Pathways and Genes of Interest
  • Mechanisms of Healing in Coiled Intracranial Aneurysms: A Review of the Literature
  • HydroCoils Reduce Recurrence Rates in Recently Ruptured Medium-Sized Intracranial Aneurysms: A Subgroup Analysis of the HELPS Trial
  • Correlation of thrombus formation on 7 T MRI with histology in a rat carotid artery side wall aneurysm model
  • Reactive tissue proliferation and damage of elastic lamina caused by hydrogel coated coils in experimental rat aneurysms
  • Creation of sidewall aneurysm in rabbits: aneurysm patency and growth follow-up
  • The next generation HydroCoil: initial clinical experience with the HydroFill embolic coil
  • Review of 2 Decades of Aneurysm-Recurrence Literature, Part 1: Reducing Recurrence after Endovascular Coiling
  • Creation of Bifurcation-Type Elastase-Induced Aneurysms in Rabbits
  • 1-Hexyl n-cyanoacrylate compound (Neucrylate™ AN), a new berry aneurysm treatment. II. Rabbit implant studies: technique and histology
  • Embolization of intracranial aneurysms with second-generation Matrix-2 detachable coils: mid-term and long-term results
  • The Woven EndoBridge: A New Aneurysm Occlusion Device
  • Improved Microsurgical Creation of Venous Pouch Arterial Bifurcation Aneurysms in Rabbits
  • Creation of Large Elastase-Induced Aneurysms: Presurgical Arterial Remodeling Using Arteriovenous Fistulas
  • Angiographic and Clinical Outcomes in 200 Consecutive Patients with Cerebral Aneurysm Treated with Hydrogel-Coated Coils
  • Angiographic and Histologic Comparison of Experimental Aneurysms Embolized with Hydrogel Filaments
  • Endovascular Histologic Effects of Ultrathin Gold- or Vitronectin-Coated Platinum Aneurysm Coils in a Rodent Arterial Occlusion Model: A Preliminary Investigation
  • Endovascular Treatment of Experimental Aneurysms with Use of Fibroblast Transfected with Replication-Deficient Adenovirus Containing Bone Morphogenetic Protein-13 Gene
  • Endovascular Treatment of Intracranial Aneurysms with Matrix Detachable Coils: Midterm Anatomic Follow-Up from a Prospective Multicenter Registry
  • Relationship Between Aneurysm Volume and Histologic Healing after Coil Embolization in Elastase-Induced Aneurysms: A Retrospective Study
  • Isolated Progressive Visual Loss after Coiling of Paraclinoid Aneurysms
  • A New Endoluminal, Flow-Disrupting Device for Treatment of Saccular Aneurysms
  • Bone Formation in Elastase-Induced Rabbit Aneurysms Embolized with Platinum Coils: Report of 2 Cases
  • Control of Aneurysm Volume by Adjusting the Position of Ligation During Creation of Elastase-Induced Aneurysms: A Prospective Study
  • Endovascular Treatment of Aneurysms: Healing Mechanisms in a Swine Model Are Associated with Increased Expression of Matrix Metalloproteinases, Vascular Cell Adhesion Molecule-1, and Vascular Endothelial Growth Factor, and Decreased Expression of Tissue Inhibitors of Matrix Metalloproteinases
  • Interventional Neuroradiology: The Role of Experimental Models in Scientific Progress
  • Aseptic Meningitis after Embolization of Cerebral Aneurysms Using Hydrogel-Coated Coils: Report of Three Cases
  • Endovascular treatment of intracranial aneurysms with matrix detachable coils: immediate posttreatment results from a prospective multicenter registry.
  • Endosaccular Treatment of Intracranial Aneurysms Using Matrix Coils: Early Experience and Midterm Follow-Up
  • Scopus (104)
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Comparing Morphology and Hemodynamics of Stable-versus-Growing and Grown Intracranial Aneurysms
  • Optimizing the Quality of 4D-DSA Temporal Information
  • Identification of Vortex Cores in Cerebral Aneurysms on 4D Flow MRI
Show more INTERVENTIONAL

Similar Articles

Advertisement

News and Updates

  • 2018 Lucien Levy Best Research Article Award
  • Thanks to our 2019 Distinguished Reviewers
  • Press Releases

Resources

  • Evidence-Based Medicine Level Guide
  • How to Participate in a Tweet Chat
  • AJNR Podcast Archive
  • Ideas for Publicizing Your Research
  • Librarian Resources
  • Terms and Conditions

Opportunities

  • Share Your Art in Perspectives
  • Get Peer Review Credit from Publons
  • Moderate a Tweet Chat

American Society of Neuroradiology

  • Neurographics
  • ASNR Annual Meeting
  • Fellowship Portal
  • Position Statements

© 2019 by the American Society of Neuroradiology | Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire