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Research ArticlePEDIATRICS

Involvement of the Anterior Lobe of the Cerebellar Vermis in Perinatal Profound Hypoxia

D.J.A. Connolly, E. Widjaja and P.D. Griffiths
American Journal of Neuroradiology January 2007, 28 (1) 16-19;
D.J.A. Connolly
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E. Widjaja
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P.D. Griffiths
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Abstract

BACKGROUND AND PURPOSE: We report abnormal high T2 signal intensity in the anterior lobe of the cerebellar vermis that we believe was the result of profound hypoxic ischemic encephalopathy in the perinatal period in term infants. We tested the hypothesis that this sign was associated with other signs of significant perinatal hypoxic damage.

METHODS: Thirty patients with clinically and radiologically confirmed perinatal profound hypoxia close to term were included in the study. The cranial MR images were reviewed by 2 pediatric neuroradiologists and were scored for the presence and severity of hypoxia/ischemia in the regions typically affected by profound hypoxia. The presence or absence of high T2 signal intensity in the vermis and other sites was correlated with the extent of damage in typically affected regions.

RESULTS: Eighteen of 30 patients had high T2 signal intensity in the vermis. The presence of vermian damage correlated positively with radiologic evidence of severe hypoxic damage and extremely poor (0 or 1) 1-minute Apgar scores.

CONCLUSIONS: High T2 signal intensity in the anterior lobe of the vermis probably represents gliosis secondary to hypoxia/ischemia and is related to the severity of damage in the term infant.

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American Journal of Neuroradiology: 28 (1)
American Journal of Neuroradiology
Vol. 28, Issue 1
January 2007
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Involvement of the Anterior Lobe of the Cerebellar Vermis in Perinatal Profound Hypoxia
D.J.A. Connolly, E. Widjaja, P.D. Griffiths
American Journal of Neuroradiology Jan 2007, 28 (1) 16-19;

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Involvement of the Anterior Lobe of the Cerebellar Vermis in Perinatal Profound Hypoxia
D.J.A. Connolly, E. Widjaja, P.D. Griffiths
American Journal of Neuroradiology Jan 2007, 28 (1) 16-19;
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Cited By...

  • Patent Ductus Arteriosus and Brain Volume
  • Injury to the Cerebellum in Term Asphyxiated Newborns Treated with Hypothermia
  • Low Cerebellar Vermis Volumes and Impaired Neuropsychologic Performance in Children Treated for Brain Tumors and Leukemia
  • Anatomic Localization of Dyskinesia in Children with "Profound" Perinatal Hypoxic-Ischemic Injury
  • Injury to the Developing Cerebellum: Mechanisms and Consequences
  • Selective Vulnerability and the Cerebellum in Neonates
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