Article Figures & Data
Figures
- Fig 1.
Outlining volumes-of-interest in the coronal plane of magnetization transfer ratio maps of a patient with Alzheimer disease: left and right hippocampal and central pontine regions (A) and left and right parietal white matter regions (B).
- Fig 2.
Receiver operating curves plotting the sensitivity and specificity of differentiating Alzheimer disease patients from control subjects by measuring adjusted volume, mean magnetization transfer ratio or both for whole brain (A) and hippocampal regions (B).
- Fig 3.
Relationship between adjusted whole brain volume and MMSE score among patients with AD and control subjects. The line indicates the linear regression of adjusted whole brain volume on MMSE score among patients with AD (correlation coefficient = 0.47, P = .048).
Tables
Patients with AD(n = 18) Control Subjects(n = 18) P* Age (y) 69.1 (6.8) 67.1 (8.9) .45 Male, n (%) 10 (56) 11 (61) .74 MMSE 19.1 (6.2) 29.7 (0.6) <.0001 Adjusted WB volume (ml) 1019 (76) 1125 (61) <.0001 Adjusted total Hc volume (ml) 4.13 (0.70) 5.64 (0.51) <.0001 WB MTR (pu) 39.79 (0.72) 40.51 (0.58) .002 Hc mean MTR (pu) 36.71 (0.78) 37.92 (0.62) <.0001 PWM mean MTR (pu) 44.60 (1.20) 44.98 (0.71) .26 Pons mean MTR (pu) 44.49 (1.72) 44.37 (1.62) .83 WB MTR peak height (%vol/pu) 7.29 (0.66) 7.60 (0.31) .08 WB MTR peak location (pu) 42.43 (1.01) 42.47 (0.86) .92 WB MTR 25th percentile (pu) 36.42 (1.15) 37.14 (0.62) .03 WB MTR median (pu) 40.94 (0.79) 41.31 (0.53) .11 WB MTR 75th percentile (pu) 44.58 (0.58) 44.75 (0.49) .34 Note:—MMSE indicates Mini-Mental State Examination; WB, whole brain; Hc, hippocampus; pu, percentage units; vol, volume; MTR, magnetization transfer ratio; PWM, parietal white matter. Values are mean (SD) unless otherwise specified.
* Two-sample t test for all comparisons except sex, where Pearson χ2 test was used.
- Table 2:
Pearson correlation coefficients (r) for the associations between MMSE and various MR imaging measures among patients with AD (n = 18)
r P Adjusted WB volume 0.47 .048 Adjusted total Hc volume 0.18 .47 WB mean MTR 0.00 .99 Total Hc mean MTR 0.19 .44 Total PWM mean MTR 0.10 .71 Pons mean MTR 0.09 .71 WB MTR peak height 0.03 .90 WB MTR peak location 0.17 .49 WB MTR 25th percentile 0.12 .63 WB MTR median 0.17 .47 WB MTR 75th percentile 0.21 .40 Note:—MMSE indicates Mini-Mental State Examination; WB, whole brain; Hc, hippocampus; MTR, magnetization transfer ratio; PWM, parietal white matter.
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