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Research ArticleBRAIN

Altered Diffusion in the Frontal Lobe in Parkinson Disease

A.T. Karagulle Kendi, S. Lehericy, M. Luciana, K. Ugurbil and P. Tuite
American Journal of Neuroradiology March 2008, 29 (3) 501-505; DOI: https://doi.org/10.3174/ajnr.A0850
A.T. Karagulle Kendi
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S. Lehericy
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M. Luciana
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K. Ugurbil
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P. Tuite
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    Fig 1.

    Axial FA (A) and MD (B) images of a control subject at the level of the basal ganglia.

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    Fig 2.

    A, A glass brain showing significant clusters of reduced FA in patients with PD compared with control subjects as viewed from the right (upper left), front (upper right), and above (lower left). SPM display is according to radiologic convention (right-to-left orientation). B, The statistical map is superimposed on the normalized average FA image. The images are in MNI space. Color bar indicates z-score. Clusters were considered significant at P < .05, corrected for multiple comparisons.

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    Table 1:

    Demographic data and clinical scores of subject population

    Group (No.)Sex (M/F)Age (yr)Disease Duration (yr)HYHYUPDRSUPDRSMMSE
    Mean (SD)Mean (SD)(ON)(OFF)(ON)(OFF)(ON)
    PD (12)5/762.1 (12.7)5.8 (4.5)1.8 (0.4)*1.9 (0.6)43 (13.8)a53.3 (22.1)28.2
    Controls (13)8/558.0 (7.3)N/AN/AN/AN/AN/A28.8
    • Note:—NA indicates data not available; M, male; F, female; HY, Hoehn and Yahr clinical staging; UPDRS, Unified Parkinson Disease Rating Scale; MMSE, Mini-Mental State Examination; ON, taking medication as normal; OFF, cessation of medication.

    • * Levodopa equivalent dosage = 585.2 ± 509.8 mg.

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    Table 2:

    Peaks for significant clusters of decreased FA in patients with PD*

    PD Versus ControlsHemisphereBrodmann AreaMNI CoordinatesZ-Score
    xyz
    Medial frontal cortex
        SMAL6−414463.3
        Pre-SMAR8426522.79
    R6618602.83
        Rostral medial frontal gyrusR9646362.97
    Cingulate cortex
        Anterior cingulate gyrus240−6464.12
    L24−634463.41
    32014383.00
    L32−826283.11
        Rostral cingulate gyrusR241030183.00
    L32−84422.82
    L9−846223.18
    Dorsolateral prefrontal cortex
        Superior frontal gyrusR91844324.14
        Middle frontal gyrusR462842143.50
        Inferior frontal gyrusR46423462.93
        Frontal pole
        Middle frontal gyrusR102046103.17
    L10−284283.06
    WM bundles
        Superior longitudinal fasciculusR3026163.09
        Corpus callosumL−1634103.02
    • Note:—SMA indicates supplementary motor area; MNI, Montreal Neurologic Institute.

    • * All significant maxima were part of a single large cluster, including 3927 voxels.

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American Journal of Neuroradiology: 29 (3)
American Journal of Neuroradiology
Vol. 29, Issue 3
March 2008
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Altered Diffusion in the Frontal Lobe in Parkinson Disease
A.T. Karagulle Kendi, S. Lehericy, M. Luciana, K. Ugurbil, P. Tuite
American Journal of Neuroradiology Mar 2008, 29 (3) 501-505; DOI: 10.3174/ajnr.A0850

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Altered Diffusion in the Frontal Lobe in Parkinson Disease
A.T. Karagulle Kendi, S. Lehericy, M. Luciana, K. Ugurbil, P. Tuite
American Journal of Neuroradiology Mar 2008, 29 (3) 501-505; DOI: 10.3174/ajnr.A0850
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