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Research ArticleSPINE

Vertebroplasty in Multiple Myeloma: Outcomes in a Large Patient Series

R.J. McDonald, A.T. Trout, L.A. Gray, A. Dispenzieri, K.R. Thielen and D.F. Kallmes
American Journal of Neuroradiology April 2008, 29 (4) 642-648; DOI: https://doi.org/10.3174/ajnr.A0918
R.J. McDonald
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A.T. Trout
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L.A. Gray
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A. Dispenzieri
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K.R. Thielen
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D.F. Kallmes
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    Fig 1.

    Sagittal T1 MR imaging demonstrating fracture types. Stars indicate treated fractures. A, Type 1 fracture, considered probably osteoporotic in nature. Areas of preserved, high T1 signal intensity within the fractured vertebral body, without focal intravertebral lesion and no evidence for pedicle involvement or epidural or paraspinal disease (not shown). B, Type 2 fracture, indeterminate for underlying lesions. Diffusely low signal intensity marrow throughout the spine. No focal lesion or epidural or paraspinal lesion within the treated vertebral body. C, Type 3 fracture, with clear evidence for myelomatous lesion within the treated vertebral body.

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    Fig 2.

    Treated and affected levels. Vertebral level frequency histograms of 114 treated vertebral levels (A) and 216 affected vertebral levels (B) in the 67 patients composing the myeloma study population. Diffuse myeloma involvement (>10 vertebral bodies) was not included in this histogram.

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    Fig 3.

    Time to treatment. Time to treatment of myeloma study participants is shown as a function of a frequency histogram with each bin representing a 4-month period.

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    Fig 4.

    Objective clinical outcome scores over time. Mean (± SD) RDQ and analog pain scale (pain with rest and activity) scores are shown preoperatively (baseline), postoperatively, and 1 week, 1 month, 6 months, and 1 year after vertebroplasty.

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  • Subjective outcome scores collected throughout follow-up

    VariableTime
    Postoperation1 Week1 Month6 Months1 Year
    Rest pain+1.25+1.33+1.29+1.53+1.49
    Active pain+1.10+1.12+1.00+1.33+1.12
    Mobility+0.76+0.67+0.83+1.00
    Narcotic use+0.81+0.84+0.93+0.94
    • Note:—Subjective outcome scores as compared with preoperative status: +2 indicates total improvement; +1, some improvement; 0, no change; −1, worse. Scores were calculated as described in the Methods section. Mobility and narcotic use were not determined until 1 week had passed after treatment.

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American Journal of Neuroradiology: 29 (4)
American Journal of Neuroradiology
Vol. 29, Issue 4
April 2008
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Vertebroplasty in Multiple Myeloma: Outcomes in a Large Patient Series
R.J. McDonald, A.T. Trout, L.A. Gray, A. Dispenzieri, K.R. Thielen, D.F. Kallmes
American Journal of Neuroradiology Apr 2008, 29 (4) 642-648; DOI: 10.3174/ajnr.A0918

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Vertebroplasty in Multiple Myeloma: Outcomes in a Large Patient Series
R.J. McDonald, A.T. Trout, L.A. Gray, A. Dispenzieri, K.R. Thielen, D.F. Kallmes
American Journal of Neuroradiology Apr 2008, 29 (4) 642-648; DOI: 10.3174/ajnr.A0918
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Cited By...

  • Evaluating Treatment Strategies for Spinal Lesions in Multiple Myeloma: A Review of the Literature
  • Trends in vertebral augmentation for spinal fractures in myeloma patients: a 2002-2012 population-based study using a large national cancer registry
  • Effect of Systemic Therapies on Outcomes following Vertebroplasty among Patients with Multiple Myeloma
  • Vertebral Augmentation in Patients with Multiple Myeloma: A Pooled Analysis of Published Case Series
  • International Myeloma Working Group Recommendations for the Treatment of Multiple Myeloma-Related Bone Disease
  • Extending the Arm of Augmentation Beyond the Neuroaxis
  • Mortality in the Vertebroplasty Population
  • Asymptomatic and Unrecognized Cement Pulmonary Embolism Commonly Occurs with Vertebroplasty
  • P.S. Augmentation
  • Clinical Outcomes with Hemivertebral Filling during Percutaneous Vertebroplasty
  • Efficacy of Percutaneous Vertebroplasty for Multiple Synchronous and Metachronous Vertebral Compression Fractures
  • Vertebroplasty for the Treatment of Traumatic Nonosteoporotic Compression Fractures
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