Thank you for your interest in our article1 and for sharing your interesting case. The proton MR spectra fit well with that of another patient with neurodegenerative Langerhans cell histiocytosis (ND-LCH) previously reported.2 Decreased N-acetylaspartate peak accompanied by increased choline in the area of cerebellar signal intensity alterations supports the concept of a neurodegenerative process. Further studies are necessary to evaluate the sensitivity and specificity of 1H-MR spectroscopy in ND-LCH.
- Copyright © American Society of Neuroradiology