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OtherREVIEW ARTICLES
Open Access

Lyme Neuroborreliosis: Manifestations of a Rapidly Emerging Zoonosis

P. Hildenbrand, D.E. Craven, R. Jones and P. Nemeskal
American Journal of Neuroradiology June 2009, 30 (6) 1079-1087; DOI: https://doi.org/10.3174/ajnr.A1579
P. Hildenbrand
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D.E. Craven
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R. Jones
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P. Nemeskal
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References

  1. ↵
    Aberer E. Lyme borreliosis: an update [in English, German]. J Dtsch Dermatol Ges 2007;5:406–14
    CrossRefPubMed
  2. ↵
    Jensenius M, Parola P, Raoult D. Threats to international travellers posed by tick-borne diseases. Travel Med Infect Dis 2006;4:4–13. Epub 2004 Dec 20
    CrossRefPubMed
  3. ↵
    Centers for Disease Control and Prevention (CDC). Lyme disease: United States, 2003–2005. MMWR Morb Mortal Wkly Rep 2007;56:573–76
    PubMed
  4. ↵
    Mast WE, Burrows WM, Jr. Erythema chronicum migrans in the United States. JAMA 1976;236:859–60
    CrossRefPubMedWeb of Science
  5. ↵
    Mast WE, Burrows WM. Erythema chronicum migrans and “lyme arthritis.” JAMA 1976;236:2392
    CrossRefPubMed
  6. ↵
    Burgdorfer W, Barbour AG, Hayes SF, et al. Lyme disease: a tick-borne spirochetosis? Science 1982;216:1317–19
    Abstract/FREE Full Text
  7. ↵
    Steere AC, Grodzicki RL, Kornblatt AN, et al. The spirochetal etiology of Lyme disease. N Engl J Med 1983;308:733–40
    CrossRefPubMedWeb of Science
  8. ↵
    Pachner AR, Steiner I. Lyme neuroborreliosis: infection, immunity, and inflammation. Lancet Neurol 2007;6:544–52
    CrossRefPubMedWeb of Science
  9. ↵
    Reed KD, Meece JK, Henkel JS, et al. Birds, migration and emerging zoonoses: west Nile virus, Lyme disease, influenza A and enteropathogens. Clin Med Res 2003;1:5–12
    Abstract/FREE Full Text
  10. Halperin JJ. Nervous system Lyme disease. Vector Borne Zoonotic Dis 2002;2:241–47
    CrossRefPubMed
  11. ↵
    van Dam AP. Diversity of Ixodes-borne Borrelia species: clinical, pathogenetic, and diagnostic implications and impact on vaccine development. Vector Borne Zoonotic Dis 2002;2:249–54
    CrossRefPubMed
  12. Wormser GP. Clinical practice: early Lyme disease. N Engl J Med 2006;354:2794–801
    CrossRefPubMedWeb of Science
  13. Grubhoffer L, Golovchenko M, Vancova M, et al. Lyme borreliosis: insights into tick-/host-borrelia relations. Folia Parasitol (Praha) 2005;52:279–94
    PubMed
  14. ↵
    Bratton RL, Whiteside JW, Hovan MJ, et al. Diagnosis and treatment of Lyme disease. Mayo Clin Proc 2008;83:566–71
    CrossRefPubMedWeb of Science
  15. ↵
    Halperin JJ. Lyme disease and the peripheral nervous system. Muscle Nerve 2003;28:133–43
    CrossRefPubMedWeb of Science
  16. ↵
    Hengge UR, Tannapfel A, Tyring SK, et al. Lyme borreliosis. Lancet Infect Dis 2003;3:489–500
    CrossRefPubMedWeb of Science
  17. ↵
    Steere AC. Musculoskeletal manifestations of Lyme disease. Am J Med 1995;98:44S–48S, discussion 48S–51S
    CrossRefPubMed
  18. ↵
    Vanzieleghem B, Lemmerling M, Carton D, et al. Lyme disease in a child presenting with bilateral facial nerve palsy: MRI findings and review of the literature. Neuroradiology 1998;40:739–42
    CrossRefPubMedWeb of Science
  19. ↵
    Stonehouse A, Studdiford JS, Henry CA. An update on the diagnosis and treatment of early Lyme disease: “focusing on the bull's eye, you may miss the mark.” J Emerg Med 2007 Oct 16. [Epub ahead of print]
  20. DePietropaolo DL, Powers JH, Gill JM, et al. Diagnosis of Lyme disease. Am Fam Physician 2005;72:297–304
    PubMedWeb of Science
  21. ↵
    Huppertz HI. Lyme disease in children. Curr Opin Rheumatol 2001;13:434–40
    CrossRefPubMedWeb of Science
  22. ↵
    Stanek G, Strle F. Lyme disease: European perspective. Infect Dis Clin North Am 2008;22:327–39, vii
    CrossRefPubMedWeb of Science
  23. ↵
    Senff NJ, Noordijk EM, Kim YH, et al. European Organization for Research and Treatment of Cancer and International Society for Cutaneous Lymphoma consensus recommendations for the management of cutaneous B-cell lymphomas. Blood 2008;112:1600–09. Epub 2008 Jun 20
    Abstract/FREE Full Text
  24. ↵
    Tugwell P, Dennis DT, Weinstein A, et al. Laboratory evaluation in the diagnosis of Lyme disease. Ann Intern Med 1997;127:1109–23
    CrossRefPubMedWeb of Science
  25. ↵
    Aguero-Rosenfeld ME, Wang G, Schwartz I, et al. Diagnosis of Lyme borreliosis. Clin Microbiol Rev 2005;18:484–509
    Abstract/FREE Full Text
  26. ↵
    Centers for Disease Control and Prevention (CDC). Recommendations for test performance and interpretation from the Second National Conference on Serologic Diagnosis of Lyme Disease. MMWR Morb Mortal Wkly Rep 1995;44:590–91
    PubMed
  27. Centers for Disease Control and Prevention (CDC). Effect of electronic laboratory reporting on the burden of Lyme disease surveillance: New Jersey, 2001–2006. MMWR Morb Mortal Wkly Rep 2008;57:42–45
    PubMed
  28. ↵
    Klempner MS, Schmid CH, Hu L, et al. Intralaboratory reliability of serologic and urine testing for Lyme disease. Am J Med 2001;110:217–19
    CrossRefPubMedWeb of Science
  29. ↵
    Pachner AR. The immune response to infectious diseases of the central nervous system: a tenuous balance. Springer Semin Immunopathol 1996;18:25–34
    CrossRefPubMedWeb of Science
  30. ↵
    Steere AC. Lyme disease. N Engl J Med 2001;345:115–25
    CrossRefPubMedWeb of Science
  31. ↵
    Rupprecht TA, Koedel U, Fingerle V, et al. The pathogenesis of Lyme neuroborreliosis: from infection to inflammation. Mol Med 2008;14:205–12
    PubMedWeb of Science
  32. ↵
    Halperin JJ. Nervous system Lyme disease. Infect Dis Clin North Am 2008;22:261–74
    CrossRefPubMedWeb of Science
  33. Tilly K, Rosa PA, Stewart PE. Biology of infection with Borrelia burgdorferi. Infect Dis Clin North Am 2008;22:217–34, v
    CrossRefPubMedWeb of Science
  34. ↵
    Hoppa E, Bachur R. Lyme disease update. Curr Opin Pediatr 2007;19:275–80
    PubMed
  35. ↵
    Halperin JJ. North American Lyme neuroborreliosis. Scand J Infect Dis Suppl 1991;77:74–80
    PubMed
  36. ↵
    Donaldson JO, Lewis RA. Lymphocytic meningoradiculitis in the United States. Neurology 1983;33:1476–79
    Abstract/FREE Full Text
  37. ↵
    Demaerel P, Crevits I, Casteels-Van Daele M, et al. Meningoradiculitis due to borreliosis presenting as low back pain only. Neuroradiology 1998;40:126–27
    CrossRefPubMed
  38. ↵
    Ljostad U, Okstad S, Topstad T, et al. Acute peripheral facial palsy in adults. J Neurol 2005;252:672–76
    CrossRefPubMedWeb of Science
  39. ↵
    Lesser RL. Ocular manifestations of Lyme disease. Am J Med 1995;98:60S–62S
    PubMed
  40. ↵
    Hattingen E, Weidauer S, Kieslich M, et al. MR imaging in neuroborreliosis of the cervical spinal cord. Eur Radiol 2004;14:2072–75
    CrossRefPubMedWeb of Science
  41. ↵
    Boukobza M, Guichard JP, Merland JJ, et al. Facial diplegia in the course of childhood Lyme disease: bilateral enhancement of the facial nerve and MRI after injection of gadolinium [in French]. J Neuroradiol 1997;24:270–73
    PubMed
  42. ↵
    Savas R, Sommer A, Gueckel F, et al. Isolated oculomotor nerve paralysis in Lyme disease: MRI. Neuroradiology 1997;39:139–41
    CrossRefPubMed
  43. ↵
    Nelson JA, Wolf MD, Yuh WT, et al. Cranial nerve involvement with Lyme borreliosis demonstrated by magnetic resonance imaging. Neurology 1992;42 (3 pt 1):671–73
    Abstract/FREE Full Text
  44. ↵
    Mantienne C, Albucher JF, Catalaa I, et al. MRI in Lyme disease of the spinal cord. Neuroradiology 2001;43:485–88
    CrossRefPubMed
  45. ↵
    Wormser GP, McKenna D, Carlin J, et al. Brief communication: hematogenous dissemination in early Lyme disease. Ann Intern Med 2005;142:751–55
    CrossRefPubMedWeb of Science
  46. ↵
    Morgen K, Martin R, Stone RD, et al. FLAIR and magnetization transfer imaging of patients with post-treatment Lyme disease syndrome. Neurology 2001;57:1980–85
    Abstract/FREE Full Text
  47. ↵
    Logigian EL, Kaplan RF, Steere AC. Chronic neurologic manifestations of lyme disease. N Engl J Med 1990;323:1438–44
    CrossRefPubMedWeb of Science
  48. ↵
    Oksi J, Kalimo H, Marttila RJ, et al. Inflammatory brain changes in Lyme borreliosis: a report on three patients and review of literature. Brain 1996;119 (pt 6):2143–54
    Abstract/FREE Full Text
  49. ↵
    Steinbach JP, Melms A, Skalej M, et al. Delayed resolution of white matter changes following therapy of B burgdorferi encephalitis. Neurology 2005;64:758–59
    FREE Full Text
  50. Oschmann P, Dorndorf W, Hornig C, et al. Stages and syndromes of neuroborreliosis. J Neurol 1998;245:262–72
    CrossRefPubMedWeb of Science
  51. ↵
    Massengo SA, Bonnet F, Braun C, et al. Severe neuroborreliosis: the benefit of prolonged high-dose combination of antimicrobial agents with steroids—an illustrative case. Diagn Microbiol Infect Dis 2005;51:127–30
    CrossRefPubMed
  52. ↵
    Pachner AR, Duray P, Steere AC. Central nervous system manifestations of Lyme disease. Arch Neurol 1989;46:790–95
    CrossRefPubMedWeb of Science
  53. ↵
    Rafto SE, Milton WJ, Galetta SL, et al. Biopsy-confirmed CNS Lyme disease: MR appearance at 1.5 T. AJNR Am J Neuroradiol 1990;11:482–84
    FREE Full Text
  54. ↵
    Murray R, Morawetz R, Kepes J, et al. Lyme neuroborreliosis manifesting as an intracranial mass lesion. Neurosurgery 1992;30:769–73
    PubMedWeb of Science
  55. ↵
    Halperin JJ. Nervous system manifestations of Lyme disease. Rheum Dis Clin North Am 1989;15:635–47
    PubMedWeb of Science
  56. ↵
    Fernandez RE, Rothberg M, Ferencz G, et al. Lyme disease of the CNS: MR imaging findings in 14 cases. AJNR Am J Neuroradiol 1990;11:479–81
    Abstract/FREE Full Text
  57. ↵
    Fadil H, Kelley RE, Gonzalez-Toledo E. Differential diagnosis of multiple sclerosis. Int Rev Neurobiol 2007;79:393–422
    CrossRefPubMed
  58. ↵
    Agosta F, Rocca MA, Benedetti B, et al. MR imaging assessment of brain and cervical cord damage in patients with neuroborreliosis. AJNR Am J Neuroradiol 2006;27:892–94
    Abstract/FREE Full Text
  59. Latsch K, Tappe D, Warmuth-Metz M, et al. Central nervous system borreliosis mimicking a pontine tumour. J Med Microbiol 2006;55 (pt 11):1597–99
    Abstract/FREE Full Text
  60. Van der Stappen A, De Cauwer H, van den Hauwe L. MR findings in acute cerebellitis. Eur Radiol 2005;15:1071–72
    CrossRefPubMed
  61. Schmutzhard E. Multiple sclerosis and Lyme borreliosis. Wien Klin Wochenschr 2002;114:539–43
    PubMed
  62. Kieslich M, Fiedler A, Driever PH, et al. Lyme borreliosis mimicking central nervous system malignancy: the diagnostic pitfall of cerebrospinal fluid cytology. Brain Dev 2000;22:403–06
    CrossRefPubMedWeb of Science
  63. ↵
    Karussis D, Weiner HL, Abramsky O. Multiple sclerosis vs Lyme disease: a case presentation to a discussant and a review of the literature. Mult Scler 1999;5:395–402
    FREE Full Text
  64. Triulzi F, Scotti G. Differential diagnosis of multiple sclerosis: contribution of magnetic resonance techniques. J Neurol Neurosurg Psychiatry 1998;64 (suppl 1):S6–14
    CrossRefPubMed
  65. ↵
    Logigian EL, Johnson KA, Kijewski MF, et al. Reversible cerebral hypoperfusion in Lyme encephalopathy. Neurology 1997;49:1661–70
    Abstract/FREE Full Text
  66. ↵
    Martin R, Gran B, Zhao Y, et al. Molecular mimicry and antigen-specific T cell responses in multiple sclerosis and chronic CNS Lyme disease. J Autoimmun 2001;16:187–92
    CrossRefPubMedWeb of Science
  67. ↵
    Pohl-Koppe A, Logigian EL, Steere AC, et al. Cross-reactivity of Borrelia burgdorferi and myelin basic protein-specific T cells is not observed in borrelial encephalomyelitis. Cell Immunol 1999;194:118–23
    CrossRefPubMed
  68. ↵
    Chehrenama M, Zagardo MT, Koski CL. Subarachnoid hemorrhage in a patient with Lyme disease. Neurology 1997;48:520–23
    Abstract/FREE Full Text
  69. Seijo Martinez M, Grandes Ibanez J, Sanchez Herrero J, et al. Spontaneous brain hemorrhage associated with Lyme neuroborreliosis. Neurologia 2001;16:43–45
    PubMed
  70. Topakian R, Stieglbauer K, Aichner FT. Unexplained cerebral vasculitis and stroke: keep Lyme neuroborreliosis in mind. Lancet Neurol 2007;6:756–57, author reply 757
    CrossRefPubMed
  71. Hammers-Berggren S, Grondahl A, Karlsson M, et al. Screening for neuroborreliosis in patients with stroke. Stroke 1993;24:1393–96
    Abstract/FREE Full Text
  72. Schmitt AB, Kuker W, Nacimiento W. Neuroborreliosis with extensive cerebral vasculitis and multiple cerebral infarcts [in German]. Nervenarzt 1999;70:167–71
    CrossRefPubMedWeb of Science
  73. Cox MG, Wolfs TF, Lo TH, et al. Neuroborreliosis causing focal cerebral arteriopathy in a child. Neuropediatrics 2005;36:104–07
    CrossRefPubMedWeb of Science
  74. Romi F, Krakenes J, Aarli JA, et al. Neuroborreliosis with vasculitis causing stroke-like manifestations. Eur Neurol 2004;51:49–50
    CrossRefPubMedWeb of Science
  75. ↵
    Schmiedel J, Gahn G, von Kummer R, et al. Cerebral vasculitis with multiple infarcts caused by Lyme disease. Cerebrovasc Dis 2004;17:79–81
    CrossRefPubMed
  76. ↵
    Logigian EL, Kaplan RF, Steere AC. Successful treatment of Lyme encephalopathy with intravenous ceftriaxone. J Infect Dis 1999;180:377–83
    Abstract/FREE Full Text
  77. ↵
    Sumiya H, Kobayashi K, Mizukoshi C, et al. Brain perfusion SPECT in Lyme neuroborreliosis. J Nucl Med 1997;38:1120–22
    Abstract/FREE Full Text
  78. ↵
    Bodaghi B. Ocular manifestations of Lyme disease[in French]. Med Mal Infect 2007;37:518–22. Epub 2007 Mar 21
    PubMedWeb of Science
  79. ↵
    Zagorski Z, Biziorek B, Haszcz D. Ophthalmic manifestations in Lyme borreliosis [in Polish]. Przegl Epidemiol 2002;56 (suppl 1):85–90
    PubMed
  80. ↵
    Fatterpekar GM, Gottesman RI, Sacher M, et al. Orbital Lyme disease: MR imaging before and after treatment—case report. AJNR Am J Neuroradiol 2002;23:657–59
    Abstract/FREE Full Text
  81. ↵
    Sood SK. What we have learned about Lyme borreliosis from studies in children. Wien Klin Wochenschr 2006;118:638–42
    CrossRefPubMed
  82. ↵
    Belman AL, Coyle PK, Roque C, et al. MRI findings in children infected by Borrelia burgdorferi. Pediatr Neurol 1992;8:428–31
    CrossRefPubMed
  83. ↵
    Shapiro ED, Seltzer EG. Lyme disease in children. Semin Neurol 1997;17:39–44
    CrossRefPubMedWeb of Science
  84. ↵
    Belman AL, Iyer M, Coyle PK, et al. Neurologic manifestations in children with North American Lyme disease. Neurology 1993;43:2609–14
    Abstract/FREE Full Text
  85. Kan L, Sood SK, Maytal J. Pseudotumor cerebri in Lyme disease: a case report and literature review. Pediatr Neurol 1998;18:439–41
    CrossRefPubMedWeb of Science
  86. Rothermel H, Hedges TR 3rd, Steere AC. Optic neuropathy in children with Lyme disease. Pediatrics 2001;108:477–81
    Abstract/FREE Full Text
  87. Smith V, Traquina DN. Pediatric bilateral facial paralysis. Laryngoscope 1998;108 (4 pt 1):519–23
    CrossRefPubMed
  88. Kacinski M, Zajac A, Skowronek-Bala B, et al. CNS Lyme disease manifestation in children. Przegl Lek 2007;64 (suppl 3):38–40
    PubMed
  89. ↵
    Lopez-Alberola RF. Neuroborreliosis and the pediatric population: a review. Rev Neurol 2006;42 (suppl 3):S91–96
    PubMed
  90. ↵
    Feder HM Jr. Lyme disease in children. Infect Dis Clin North Am 2008;22:315–26, vii
    CrossRefPubMedWeb of Science
  91. ↵
    Feder HM Jr, Johnson BJ, O'Connell S, et al. A critical appraisal of “chronic Lyme disease.” N Engl J Med 2007;357:1422–30
    CrossRefPubMedWeb of Science
  92. Donta ST. Late and chronic Lyme disease. Med Clin North Am 2002;86:341–49, vii
    CrossRefPubMedWeb of Science
  93. Sigal LH. Persisting complaints attributed to chronic Lyme disease: possible mechanisms and implications for management. Am J Med 1994;96:365–74
    CrossRefPubMedWeb of Science
  94. Hurley RA, Taber KH. Acute and chronic Lyme disease: controversies for neuropsychiatry. J Neuropsychiatry Clin Neurosci 2008;20:iv -6
    CrossRefPubMed
  95. ↵
    Tager FA, Fallon BA, Keilp J, et al. A controlled study of cognitive deficits in children with chronic Lyme disease. J Neuropsychiatry Clin Neurosci 2001;13:500–07
    CrossRefPubMedWeb of Science
  96. ↵
    Marques A. Chronic Lyme disease: a review. Infect Dis Clin North Am 2008;22:341–60, vii-viii
    CrossRefPubMedWeb of Science
  97. ↵
    MacDonald AB. Alzheimer's disease Braak Stage progressions: reexamined and redefined as Borrelia infection transmission through neural circuits. Med Hypotheses 2007;68:1059–64. Epub 2006 Nov 17
    CrossRefPubMedWeb of Science
  98. Miklossy J. Chronic inflammation and amyloidogenesis in Alzheimer's disease: role of spirochetes. J Alzheimers Dis 2008;13:381–91
    PubMed
  99. MacDonald AB. Plaques of Alzheimer's disease originate from cysts of Borrelia burgdorferi, the Lyme disease spirochete. Med Hypotheses 2006;67:592–600. Epub 2006 May 3
    CrossRefPubMed
  100. Meer-Scherrer L, Chang Loa C, Adelson ME, et al. Lyme disease associated with Alzheimer's disease. Curr Microbiol 2006;52:330–32
    CrossRefPubMed
  101. Miklossy J, Khalili K, Gern L, et al. Borrelia burgdorferi persists in the brain in chronic lyme neuroborreliosis and may be associated with Alzheimer disease. J Alzheimers Dis 2004;6:639–49, discussion 673–81
    PubMedWeb of Science
  102. Bransfield RC, Wulfman JS, Harvey WT, et al. The association between tick-borne infections, Lyme borreliosis and autism spectrum disorders. Med Hypotheses 2008;70:967–74
    CrossRefPubMed
  103. Fallon BA, Das S, Plutchok JJ, et al. Functional brain imaging and neuropsychological testing in Lyme disease. Clin Infect Dis 1997;25 (suppl 1):S57–63
    CrossRefPubMedWeb of Science
  104. Fallon BA, Nields JA. Lyme disease: a neuropsychiatric illness. Am J Psychiatry 1994;151:1571–83
    PubMedWeb of Science
  105. Schneider RK, Robinson MJ, Levenson JL. Psychiatric presentations of non-HIV infectious diseases: neurocysticercosis, Lyme disease, and pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection. Psychiatr Clin North Am 2002;25:1–16
    CrossRefPubMed
  106. ↵
    Vrethem M, Hellblom L, Widlund M, et al. Chronic symptoms are common in patients with neuroborreliosis: a questionnaire follow-up study. Acta Neurol Scand 2002;106:205–08
    CrossRefPubMedWeb of Science
  107. ↵
    Aalto A, Sjowall J, Davidsson L, et al. Brain magnetic resonance imaging does not contribute to the diagnosis of chronic neuroborreliosis. Acta Radiol 2007;48:755–62
    CrossRefPubMedWeb of Science
  108. ↵
    Kurtenbach K, Hanincova K, Tsao JI, et al. Fundamental processes in the evolutionary ecology of Lyme borreliosis. Nat Rev Microbiol 2006;4:660–69
    CrossRefPubMedWeb of Science
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American Journal of Neuroradiology: 30 (6)
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Lyme Neuroborreliosis: Manifestations of a Rapidly Emerging Zoonosis
P. Hildenbrand, D.E. Craven, R. Jones, P. Nemeskal
American Journal of Neuroradiology Jun 2009, 30 (6) 1079-1087; DOI: 10.3174/ajnr.A1579

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Lyme Neuroborreliosis: Manifestations of a Rapidly Emerging Zoonosis
P. Hildenbrand, D.E. Craven, R. Jones, P. Nemeskal
American Journal of Neuroradiology Jun 2009, 30 (6) 1079-1087; DOI: 10.3174/ajnr.A1579
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  • Article
    • Abstract
    • Epidemiology and Clinical Presentation
    • Diagnostic Tests for Lyme Disease
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