Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • For Authors
  • About Us
    • About AJNR
    • Editorial Board
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Other Publications
    • ajnr

User menu

  • Subscribe
  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

  • Subscribe
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • For Authors
  • About Us
    • About AJNR
    • Editorial Board
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds
Research ArticleINTERVENTIONAL

Impact of Intra-Arterial Injection Parameters on Arterial, Capillary, and Venous Time-Concentration Curves in a Canine Model

A.S. Ahmed, Y. Deuerling-Zheng, C.M. Strother, K.A. Pulfer, M. Zellerhoff, T. Redel, K. Royalty, D. Consigny, M.J. Lindstrom and D.B. Niemann
American Journal of Neuroradiology August 2009, 30 (7) 1337-1341; DOI: https://doi.org/10.3174/ajnr.A1586
A.S. Ahmed
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Y. Deuerling-Zheng
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C.M. Strother
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K.A. Pulfer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Zellerhoff
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
T. Redel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K. Royalty
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D. Consigny
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M.J. Lindstrom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D.B. Niemann
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • References
  • PDF
Loading

Abstract

BACKGROUND AND PURPOSE: Recent advances in flat panel detector angiographic equipment have provided the opportunity to obtain physiologic and anatomic information from angiographic examinations. To exploit this possibility, one must understand the factors that affect the bolus geometry of an intra-arterial injection of contrast medium. It was our purpose to examine these factors in a canine model.

MATERIALS AND METHODS: Under an institutionally approved protocol conforming to Guide for the Care and Use of Laboratory Animals of the National Institutes of Health, 7 canines were placed under general anesthesia with isoflurane and propofol. Through a 5F catheter placed into the right common carotid artery, a series of biplane angiographic acquisitions was obtained to examine the effects caused by variation in the volume of injection, the rate of injection, the duration of injection, the concentration of contrast medium, and the catheter position on arterial, capillary, and venous opacification. The results of each injection protocol were determined from analysis of a time-contrast concentration curve derived from locations over an artery, in brain parenchyma, and over a vein. The curve was generated from 2D digital subtraction angiography acquisitions by using prototype software. The area under the curve, the amplitude of the curve, and the time to peak (TTP) were analyzed separately for each injection parameter.

RESULTS: Changes in the injection protocols resulted in predictable changes in the time-concentration curves. The injection parameter that contributed most to maximum opacification was the volume of contrast medium injected. When the injection rate was fixed and the volume was varied, there was an increase in opacification (maximal) proportional to the injected volume. The injected volume also had an indirect (secondary) impact on the temporal characteristics of the opacification. The time-concentration curve became wider, and the peak was shifted to the right as the injection duration increased. The impact of injected volume on maximal opacification was significant (P < .0001), regardless of the site of measurement (artery, tissue, and vein); however, the impact on the temporal characteristics of the time-concentration curve reached statistical significance only in measurements made in the artery and the vein (P < .05), but not in the tissue (P > .1). The impact of injected volume on maximal opacification became nonproportional in the tissue and vein when the volume was very large (>12 mL). Increasing the concentration of contrast medium resulted in a nonproportional increase in the height of the time-concentration curves (P < .05). Injection rate had an impact on both maximal opacification and TTP. The impact on TTP occurred only when the injection rate was very slow (1 mL/s). Changes of concentration had a similar impact on the time-concentration curve. Catheter position did not cause significant alterations in the shape of the curves.

CONCLUSIONS: There were predictable effects from modification of injection parameters on the contrast bolus geometry and on time-concentration curves as measured in an artery, brain parenchyma, or a vein. The amplitude, TTP, and area under the time-concentration curve depend mainly and proportionally on the amount of iodine traversing the vasculature per second. Other injection parameters were of less importance in defining bolus geometry. These findings mimic those observed in studies of parameters affecting bolus geometry following an intravenous injection.

  • American Society of Neuroradiology
View Full Text
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 30 (7)
American Journal of Neuroradiology
Vol. 30, Issue 7
August 2009
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Impact of Intra-Arterial Injection Parameters on Arterial, Capillary, and Venous Time-Concentration Curves in a Canine Model
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
Citation Tools
Impact of Intra-Arterial Injection Parameters on Arterial, Capillary, and Venous Time-Concentration Curves in a Canine Model
A.S. Ahmed, Y. Deuerling-Zheng, C.M. Strother, K.A. Pulfer, M. Zellerhoff, T. Redel, K. Royalty, D. Consigny, M.J. Lindstrom, D.B. Niemann
American Journal of Neuroradiology Aug 2009, 30 (7) 1337-1341; DOI: 10.3174/ajnr.A1586

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Impact of Intra-Arterial Injection Parameters on Arterial, Capillary, and Venous Time-Concentration Curves in a Canine Model
A.S. Ahmed, Y. Deuerling-Zheng, C.M. Strother, K.A. Pulfer, M. Zellerhoff, T. Redel, K. Royalty, D. Consigny, M.J. Lindstrom, D.B. Niemann
American Journal of Neuroradiology Aug 2009, 30 (7) 1337-1341; DOI: 10.3174/ajnr.A1586
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • References
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

Related Articles

  • No related articles found.
  • Scopus
  • PubMed
  • Google Scholar

Cited By...

  • Flat Detector CT in the Evaluation of Brain Parenchyma, Intracranial Vasculature, and Cerebral Blood Volume: A Pilot Study in Patients with Acute Symptoms of Cerebral Ischemia
  • Parametric Color Coding of Digital Subtraction Angiography
  • Scopus (19)
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Imaging Triage of Patients with Late-Window (6–24 Hours) Acute Ischemic Stroke: A Comparative Study Using Multiphase CT Angiography versus CT Perfusion
  • Emergency Conversion to General Anesthesia Is a Tolerable Risk in Patients Undergoing Mechanical Thrombectomy
  • Comparing Morphology and Hemodynamics of Stable-versus-Growing and Grown Intracranial Aneurysms
Show more INTERVENTIONAL

Similar Articles

Advertisement

News and Updates

  • 2018 Lucien Levy Best Research Article Award
  • Thanks to our 2019 Distinguished Reviewers
  • Press Releases

Resources

  • Evidence-Based Medicine Level Guide
  • How to Participate in a Tweet Chat
  • AJNR Podcast Archive
  • Ideas for Publicizing Your Research
  • Librarian Resources
  • Terms and Conditions

Opportunities

  • Share Your Art in Perspectives
  • Get Peer Review Credit from Publons
  • Moderate a Tweet Chat

American Society of Neuroradiology

  • Neurographics
  • ASNR Annual Meeting
  • Fellowship Portal
  • Position Statements

© 2019 by the American Society of Neuroradiology | Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire