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Research ArticleInterventional
Open Access

Intrinsic Pathway−Mediated Apoptosis in Elastase-Induced Aneurysms in Rabbits

R. Kadirvel, Y.H. Ding, D. Dai, D.A. Lewis and D.F. Kallmes
American Journal of Neuroradiology January 2010, 31 (1) 165-169; DOI: https://doi.org/10.3174/ajnr.A1781
R. Kadirvel
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Y.H. Ding
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D. Dai
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D.A. Lewis
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D.F. Kallmes
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    Fig 1.

    Terminal deoxynucleotidyltransferase−mediated dUTP nick end-labeling (TUNEL) staining. Immunofluorescence image of TUNEL staining at the distal neck of a 2-week aneurysm (original magnification ×150).

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    Fig 2.

    Expression of proapoptotic proteins. A, Representative Western blot images of the expression of caspase family proteins from rabbits at 2 weeks and 12 weeks post-aneurysm creation. B, Densitometric analysis of the expression of procaspase-3 between control and experimental animals. C, Densitometric analysis of the expression of cleaved-caspase-3 between control and experimental animals. D, Densitometric analysis of the expression of procaspase-8 between control and experimental animals. E, Densitometric analysis of the expression of procaspase-9 between control and experimental animals. F, Densitometric analysis of the expression of cleaved-caspase-9 between control and experimental animals. LCCA indicates left common carotid artery; PA, parent artery; AN, aneurysm neck; AD, aneurysm dome; a, P < .05 versus control; b, P < .05 versus the corresponding 2-week group.

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    Fig 3.

    Expression of antiapoptotic proteins. A, Representative Western blot images of the expression of bcl-3 and phospho-Bad from rabbits at 2 weeks and 12 weeks post-aneurysm creation. B, Densitometric analysis of the expression of bcl-2 between control and experimental animals. C, Densitometric analysis of the expression of phospho-Bad between control and experimental animals.

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American Journal of Neuroradiology: 31 (1)
American Journal of Neuroradiology
Vol. 31, Issue 1
1 Jan 2010
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Intrinsic Pathway−Mediated Apoptosis in Elastase-Induced Aneurysms in Rabbits
R. Kadirvel, Y.H. Ding, D. Dai, D.A. Lewis, D.F. Kallmes
American Journal of Neuroradiology Jan 2010, 31 (1) 165-169; DOI: 10.3174/ajnr.A1781

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Intrinsic Pathway−Mediated Apoptosis in Elastase-Induced Aneurysms in Rabbits
R. Kadirvel, Y.H. Ding, D. Dai, D.A. Lewis, D.F. Kallmes
American Journal of Neuroradiology Jan 2010, 31 (1) 165-169; DOI: 10.3174/ajnr.A1781
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