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Case ReportBrain

Methadone-Induced Toxic Leukoencephalopathy: MR Imaging and MR Proton Spectroscopy Findings

R.A. Salgado, P.G. Jorens, I. Baar, P. Cras, G. Hans and P.M. Parizel
American Journal of Neuroradiology March 2010, 31 (3) 565-566; DOI: https://doi.org/10.3174/ajnr.A1889
R.A. Salgado
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P.G. Jorens
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I. Baar
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P. Cras
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G. Hans
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P.M. Parizel
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    Fig 1.

    Axial FLAIR image with fat saturation (A) and a turbo spin-echo T2-weighted image (B). There are confluent and strikingly symmetric signal-intensity abnormalities in the white matter of both cerebral hemispheres, with sparing of the subcortical U-fibers. The posterior fossa structures are normal.

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    Fig 2.

    Proton single-voxel MR spectroscopy, performed with a TE value of 270 ms. There is a striking decrease of the NAA peak with a relative increase of the choline peak. A lactate peak with a resonance frequency at 1.32 ppm is present and shows a characteristic “up” doublet configuration.

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American Journal of Neuroradiology: 31 (3)
American Journal of Neuroradiology
Vol. 31, Issue 3
1 Mar 2010
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Methadone-Induced Toxic Leukoencephalopathy: MR Imaging and MR Proton Spectroscopy Findings
R.A. Salgado, P.G. Jorens, I. Baar, P. Cras, G. Hans, P.M. Parizel
American Journal of Neuroradiology Mar 2010, 31 (3) 565-566; DOI: 10.3174/ajnr.A1889

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Methadone-Induced Toxic Leukoencephalopathy: MR Imaging and MR Proton Spectroscopy Findings
R.A. Salgado, P.G. Jorens, I. Baar, P. Cras, G. Hans, P.M. Parizel
American Journal of Neuroradiology Mar 2010, 31 (3) 565-566; DOI: 10.3174/ajnr.A1889
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