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Case ReportPediatrics
Open Access

Progressive Decrease in N-Acetylaspartate/Creatine Ratio in a Teenager with Type 1 Diabetes and Repeated Episodes of Ketoacidosis without Clinically Apparent Cerebral Edema: Evidence for Permanent Brain Injury

S.L. Wootton-Gorges, M.H. Buonocore, R.A. Caltagirone, N. Kuppermann and N.S. Glaser
American Journal of Neuroradiology April 2010, 31 (4) 780-781; DOI: https://doi.org/10.3174/ajnr.A1829
S.L. Wootton-Gorges
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M.H. Buonocore
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R.A. Caltagirone
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N. Kuppermann
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N.S. Glaser
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References

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    1. Naguib JM,
    2. Kulinskaya E,
    3. Lomax CL,
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    . Neuro-cognitive performance in children with type 1 diabetes: a meta-analysis. J Pediatr Psychol 2009; 34: 271–82
    Abstract/FREE Full Text
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    1. Biessels GJ,
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    . Cognition and diabetes: a lifespan perspective. Lancet Neurol 2008; 7: 184–90
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    1. Ghetti S,
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    . Diabetic ketoacidosis and memory impairment in children with type 1 diabetes. J Pediatr 2010; 156: 109–14
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    1. Moffett JR,
    2. Ross B,
    3. Arun P,
    4. et al
    . N-acetylaspartate in the CNS: from neurodiagnostics to neurobiology. Prog Neruobiol 2007; 81: 89–131. Epub 2007 Jan 5
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    1. Demougeot C,
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    . N-acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury. J Neurochem 2001; 77: 408–15
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  6. 6.↵
    1. Muir AB,
    2. Quisling RG,
    3. Yang MC,
    4. et al
    . Cerebral edema in childhood diabetic ketoacidosis: natural history, radiographic findings and early identification. Diabetes Care 2004; 27: 1541–46
    Abstract/FREE Full Text
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    1. Glaser NS,
    2. Wootton-Gorges SL,
    3. Marcin JP,
    4. et al
    . Mechanism of cerebral edema in children with diabetic ketoacidosis. J Pediatr 2004; 145: 164–71
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    1. Wootton-Gorges SL,
    2. Buonocore MH,
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    4. et al
    . Cerebral proton magnetic resonance spectroscopy in children with diabetic ketoacidosis. AJNR Am J Neuroradiol 2007; 28: 895–99
    Abstract/FREE Full Text
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American Journal of Neuroradiology: 31 (4)
American Journal of Neuroradiology
Vol. 31, Issue 4
1 Apr 2010
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Progressive Decrease in N-Acetylaspartate/Creatine Ratio in a Teenager with Type 1 Diabetes and Repeated Episodes of Ketoacidosis without Clinically Apparent Cerebral Edema: Evidence for Permanent Brain Injury
S.L. Wootton-Gorges, M.H. Buonocore, R.A. Caltagirone, N. Kuppermann, N.S. Glaser
American Journal of Neuroradiology Apr 2010, 31 (4) 780-781; DOI: 10.3174/ajnr.A1829

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Progressive Decrease in N-Acetylaspartate/Creatine Ratio in a Teenager with Type 1 Diabetes and Repeated Episodes of Ketoacidosis without Clinically Apparent Cerebral Edema: Evidence for Permanent Brain Injury
S.L. Wootton-Gorges, M.H. Buonocore, R.A. Caltagirone, N. Kuppermann, N.S. Glaser
American Journal of Neuroradiology Apr 2010, 31 (4) 780-781; DOI: 10.3174/ajnr.A1829
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Cited By...

  • Recurrent diabetic ketoacidosis and cognitive function among older adults with type 1 diabetes: findings from the Study of Longevity in Diabetes
  • Cerebral Ketones Detected by 3T MR Spectroscopy in Patients with High-Grade Glioma on an Atkins-Based Diet
  • Neurological Consequences of Diabetic Ketoacidosis at Initial Presentation of Type 1 Diabetes in a Prospective Cohort Study of Children
  • Effects of Hyperglycemia and Effects of Ketosis on Cerebral Perfusion, Cerebral Water Distribution, and Cerebral Metabolism
  • Near Normalization of Metabolic and Functional Features of the Central Nervous System in Type 1 Diabetic Patients With End-Stage Renal Disease After Kidney-Pancreas Transplantation
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