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Research ArticleInterventionalE
Open Access

Higher Rates of Mortality but Not Morbidity Follow Intracranial Mechanical Thrombectomy in the Elderly

Y. Loh, D. Kim, Z.-S. Shi, S. Tateshima, P.M. Vespa, N.R. Gonzalez, S. Starkman, J.L. Saver, R. Jahan, D.S. Liebeskind, G.R. Duckwiler and F. Viñuela
American Journal of Neuroradiology August 2010, 31 (7) 1181-1185; DOI: https://doi.org/10.3174/ajnr.A2079
Y. Loh
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D. Kim
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Z.-S. Shi
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S. Tateshima
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P.M. Vespa
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N.R. Gonzalez
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S. Starkman
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J.L. Saver
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R. Jahan
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D.S. Liebeskind
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G.R. Duckwiler
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F. Viñuela
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    Fig 1.

    Discharge modified mRS scores in patients ≥80 years of age versus younger patients.

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    Table 1:

    Cohort age distribution by deciles in patients undergoing Merci thrombectomy for acute ischemic stroke

    DecileAge (yr)DecileAge (yr)
    1st14–396th71–74
    2nd39–477th74–78
    3rd48–568th78–83
    4th56–649th84–86
    5th65–7010th86–95
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    Table 2:

    Baseline characteristics of patients undergoing Merci thrombectomy for acute ischemic strokea

    Age <80 yr (n = 75)Age ≥80 yr (n = 31)P
    Age (yr)57.5 ± 16.085.9 ± 3.8
    Male sex38 (51)10 (32).1
    Dominant hemisphere or vertebrobasilar39 (52)20 (65).2
    Anterior circulation70 (93)30 (97).7
    Premorbid history of
        Cardiac disease38 (51)21 (68).1
        Hypertension41 (55)21 (68).2
        Hyperlipidemia22 (29)10 (32).8
        Diabetes16 (21)2 (6).9
        Prior stroke or TIA3 (4)1 (3)1
        Peripheral vascular disease4 (5)2 (6)1
    Cardioembolic source41 (55)25 (81).02
    AOL 2–358 (77)25 (81).8
    Time to intervention (hr)6:25 ± 2:496:21 ± 2:17.9
    Persistent mismatch following Mercib35/67 (52)16/29 (55).8
    Intravenous or IA thrombolytic27 (36)11 (35)1
    Adjunctive therapy6 (8)2 (6)1
    Admission glucose (mg/dL)142 ± 65141 ± 42.9
    • a Baseline characteristic, No. (%) unless otherwise specified.

    • b Eight patients younger than 80 year of age and 2 older did not have interpretable perfusion images.

    • View popup
    Table 3:

    Clinical outcomes, secondary end points, and HT in patients undergoing Merci thrombectomy for acute ischemic strokea

    Age <80 yr (n = 75)Age ≥80 yr (n = 31)PbAge 65–79 yr (n = 33)Pb
    Admission NIHSS18 (13–22)20 (18–23).117 (15–23).3
    Hospital length of stay (days)c10.4 ± 8.08.3 ± 5.0.36.2 ± 3.0.1
    Stroke-related death11 (15)15 (48)5.5 (2.1–14.1)8 (24)2.9 (1.0–8.5)
    Discharge NIHSS6.5 (2–42)42 (6–42).00611 (3–42).09
    Discharge NIHSS in survivorsd5 (2–12)5.5 (2–11)14 (0–11).8
    NIHSS change4.2 ± 14.4−4.9 ± 16.9.011.7 ± 15.8.1
    NIHSS change in survivorsd9.4 ± 8.610.4 ± 5.5.710.1 ± 7.5.9
    Discharge mRS4 (1–5)5 (3.5–6).0063 (0.5–4).1
    Discharge mRS in survivorsd3 (1–4)3.5 (2–4).92 (0–4).7
    mRS ≤2 in survivorsd25/62 (40)6/16 (38).9 (.3–2.8)11/23 (48)0.7 (.2–2.4)
    HTe
    Any HT within 72 hr30/72 (42)17/28 (61)2.2 (.9–5.3)13/30 (43)2.0 (.7–5.8)
    Symptomatic HT within 72 hr7/72 (10)3/28 (11).9 (.2–3.7)2/30 (7)1.7 (.3–10.9)
    Parenchymal HT within 72 hr9/72 (13)4/28 (14)1.2 (.3–4.1)3/30 (10)1.5 (.3–7.4)
    • a Clinical measure, No. (%) unless otherwise specified; all NIHSS and mRS values except NIHSS change are shown as median (interquartile range).

    • b ORs (95% CI) are shown for selected comparisons.

    • c One patient with a prolonged hospitalization due to surgery unrelated to the stroke was excluded from LOS analysis.

    • d Patients who died were not analyzed in these comparisons.

    • e Three patients in each group did not undergo imaging by 72 hours to determine HT.

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American Journal of Neuroradiology: 31 (7)
American Journal of Neuroradiology
Vol. 31, Issue 7
1 Aug 2010
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Higher Rates of Mortality but Not Morbidity Follow Intracranial Mechanical Thrombectomy in the Elderly
Y. Loh, D. Kim, Z.-S. Shi, S. Tateshima, P.M. Vespa, N.R. Gonzalez, S. Starkman, J.L. Saver, R. Jahan, D.S. Liebeskind, G.R. Duckwiler, F. Viñuela
American Journal of Neuroradiology Aug 2010, 31 (7) 1181-1185; DOI: 10.3174/ajnr.A2079

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Higher Rates of Mortality but Not Morbidity Follow Intracranial Mechanical Thrombectomy in the Elderly
Y. Loh, D. Kim, Z.-S. Shi, S. Tateshima, P.M. Vespa, N.R. Gonzalez, S. Starkman, J.L. Saver, R. Jahan, D.S. Liebeskind, G.R. Duckwiler, F. Viñuela
American Journal of Neuroradiology Aug 2010, 31 (7) 1181-1185; DOI: 10.3174/ajnr.A2079
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