Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • For Authors
  • About Us
    • About AJNR
    • Editors
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Other Publications
    • ajnr

User menu

  • Subscribe
  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

  • Subscribe
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • For Authors
  • About Us
    • About AJNR
    • Editors
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds
Research ArticleBrain
Open Access

Combined Diffusion Imaging and MR Spectroscopy in the Diagnosis of Human Prion Diseases

D. Galanaud, S. Haik, M.G. Linguraru, J.-P. Ranjeva, B. Faucheux, E. Kaphan, N. Ayache, J. Chiras, P. Cozzone, D. Dormont and J.-P. Brandel
American Journal of Neuroradiology August 2010, 31 (7) 1311-1318; DOI: https://doi.org/10.3174/ajnr.A2069
D. Galanaud
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Haik
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M.G. Linguraru
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.-P. Ranjeva
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
B. Faucheux
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
E. Kaphan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
N. Ayache
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Chiras
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P. Cozzone
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D. Dormont
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.-P. Brandel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • References
  • PDF
Loading

Abstract

BACKGROUND AND PURPOSE: The physiopathologic bases underlying the signal intensity changes and reduced diffusibility observed in prion diseases (TSEs) are still poorly understood. We evaluated the interest of MRS combined with DWI both as a diagnostic tool and a way to understand the mechanism underlying signal intensity and ADC changes in this setting.

MATERIALS AND METHODS: We designed a prospective study of multimodal MR imaging in patients with suspected TSEs. Forty-five patients with a suspicion of TSE and 11 age-matched healthy volunteers were included. The MR imaging protocol included T1, FLAIR, and DWI sequences. MRS was performed on the cerebellum, pulvinar, right lenticular nucleus, and frontal cortex. MR images were assessed visually, and ADC values were calculated.

RESULTS: Among the 45 suspected cases, 31 fulfilled the criteria for probable or definite TSEs (19 sCJDs, 3 iCJDs, 2 vCJDs, and 7 genetic TSEs); and 14 were classified as AltDs. High signals in the cortex and/or basal ganglia were observed in 26/31 patients with TSEs on FLAIR and 29/31 patients on DWI. In the basal ganglia, high DWI signals corresponded to a decreased ADC. Metabolic alterations, increased mIns, and decreased NAA were observed in all patients with TSEs. ADC values and metabolic changes were not correlated; this finding suggests that neuronal stress (vacuolization), neuronal loss, and astrogliosis do not alone explain the decrease of ADC.

CONCLUSIONS: MRS combined with other MR imaging is of interest in the diagnosis of TSE and provides useful information for understanding physiopathologic processes underlying prion diseases.

Abbreviations

ADC
apparent diffusion coefficient
AltD
alternative diagnosis
Avg
average
C (or c)
control
Cho
choline
CJD
Creutzfeldt-Jakob disease
Cr
creatine
DWI
diffusion-weighted imaging
EEG
electroencephalograph
FFI
fatal familial insomnia
FLAIR
fluid-attenuated inversion recovery
GABA
gamma-aminobutyric acid
gCJD
genetic CJD
Glx
glutamine-glutamate-GABA
GSS
Gerstmann Strausser Sheinker syndrome
iCJD
iatrogenic CJD
mIns
myo-inositol
MM
methionine homozygosity (PRNP: genotype at codon 129)
MRS
MR spectroscopy
MRI
MR imaging
MV
methionine-valine heterozygosity (PRNP: genotype at codon 129)
NA
data not available
NAA
N-acetylaspartate
NS
not significant or nonspecific slow waves
P (or p)
patient
PRNP
genotype at codon 129
PrP
prion protein or persistent plexus gene
S
sum of metabolites
sCJD
sporadic CJD
TSE
human transmissible spongiform encephalopathy
vCJD
variant CJD
VV
valine homozygosity (PRNP: genotype at codon 129)
  • Copyright © American Society of Neuroradiology

Indicates open access to non-subscribers at www.ajnr.org

View Full Text
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 31 (7)
American Journal of Neuroradiology
Vol. 31, Issue 7
1 Aug 2010
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Combined Diffusion Imaging and MR Spectroscopy in the Diagnosis of Human Prion Diseases
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Combined Diffusion Imaging and MR Spectroscopy in the Diagnosis of Human Prion Diseases
D. Galanaud, S. Haik, M.G. Linguraru, J.-P. Ranjeva, B. Faucheux, E. Kaphan, N. Ayache, J. Chiras, P. Cozzone, D. Dormont, J.-P. Brandel
American Journal of Neuroradiology Aug 2010, 31 (7) 1311-1318; DOI: 10.3174/ajnr.A2069

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Combined Diffusion Imaging and MR Spectroscopy in the Diagnosis of Human Prion Diseases
D. Galanaud, S. Haik, M.G. Linguraru, J.-P. Ranjeva, B. Faucheux, E. Kaphan, N. Ayache, J. Chiras, P. Cozzone, D. Dormont, J.-P. Brandel
American Journal of Neuroradiology Aug 2010, 31 (7) 1311-1318; DOI: 10.3174/ajnr.A2069
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • Abbreviations
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Multimodal CT Provides Improved Performance for Lacunar Infarct Detection
  • Optimal MRI Sequence for Identifying Occlusion Location in Acute Stroke: Which Value of Time-Resolved Contrast-Enhanced MRA?
  • Evaluating the Effects of White Matter Multiple Sclerosis Lesions on the Volume Estimation of 6 Brain Tissue Segmentation Methods
Show more BRAIN

Similar Articles

Advertisement

News and Updates

  • Lucien Levy Best Research Article Award
  • Thanks to our 2021 Distinguished Reviewers
  • Press Releases

Resources

  • Evidence-Based Medicine Level Guide
  • How to Participate in a Tweet Chat
  • AJNR Podcast Archive
  • Ideas for Publicizing Your Research
  • Librarian Resources
  • Terms and Conditions

Opportunities

  • Share Your Art in Perspectives
  • Get Peer Review Credit from Publons
  • Moderate a Tweet Chat

American Society of Neuroradiology

  • Neurographics
  • ASNR Annual Meeting
  • Fellowship Portal
  • Position Statements

© 2022 by the American Society of Neuroradiology | Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire