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Research ArticleBrain

Differentiation among Glioblastoma Multiforme, Solitary Metastatic Tumor, and Lymphoma Using Whole-Tumor Histogram Analysis of the Normalized Cerebral Blood Volume in Enhancing and Perienhancing Lesions

J.H. Ma, H.S. Kim, N.-J. Rim, S.-H. Kim and K.-G. Cho
American Journal of Neuroradiology October 2010, 31 (9) 1699-1706; DOI: https://doi.org/10.3174/ajnr.A2161
J.H. Ma
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H.S. Kim
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N.-J. Rim
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S.-H. Kim
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K.-G. Cho
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Abstract

BACKGROUND AND PURPOSE: The histogram method has been shown to demonstrate heterogeneous morphologic features of tumor vascularity. This study aimed to determine whether whole-tumor histogram analysis of the normalized CBV for contrast-enhancing lesions and perienhancing lesions can differentiate among GBMs, SMTs, and lymphomas.

MATERIALS AND METHODS: Fifty-nine patients with histopathologically confirmed GBMs (n = 28), SMTs (n = 22), or lymphomas (n = 12) underwent conventional MR imaging and dynamic susceptibility contrast-enhanced imaging before surgery. Histogram distribution of the normalized CBV was obtained from whole-tumor voxels in contrast-enhancing lesions and perienhancing lesions. The HW, PHP, and MV were determined from histograms. One-way ANOVA was used initially to test the overall equality of mean values for each type of tumor. Subsequently, posttest multiple comparisons were performed.

RESULTS: For whole-tumor histogram analyses for contrast-enhancing lesions, only PHP could differentiate among GBMs (4.79 ± 1.31), SMTs (3.32 ± 1.10), and lymphomas (2.08 ± 0.54). The parameters HW and MV were not significantly different between GBMs and SMTs, whereas the 2 histogram parameters were significantly higher in GBMs and SMTs compared with lymphomas. For the analyses of perienhancing lesions, only MV could differentiate among GBMs (1.90 ± 0.26), SMTs (0.80 ± 0.21), and lymphomas (1.27 ± 0.34). HW and PHP were not significantly different between SMTs and lymphomas.

CONCLUSIONS: Using a whole-tumor histogram analysis of normalized CBV for contrast-enhancing lesions and perienhancing lesions facilitates differentiation of GBMs, SMTs and lymphomas.

Abbreviations

ANOVA
analysis of variance
AUC
area under the ROC curve
CBV
cerebral blood volume
CEL
contrast-enhancing lesion
GBM
glioblastoma multiforme
HW
histogram width
ICC
intraclass correlation coefficient
MV
maximum value
NPV
negative predictive value
PEL
perienhancing lesion
PHP
peak height position
PPV
positive predictive value
rCBV
relative cerebral blood volume
ROC
receiver operating characteristic
SMT
solitary metastatic tumor
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American Journal of Neuroradiology: 31 (9)
American Journal of Neuroradiology
Vol. 31, Issue 9
1 Oct 2010
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Differentiation among Glioblastoma Multiforme, Solitary Metastatic Tumor, and Lymphoma Using Whole-Tumor Histogram Analysis of the Normalized Cerebral Blood Volume in Enhancing and Perienhancing Lesions
J.H. Ma, H.S. Kim, N.-J. Rim, S.-H. Kim, K.-G. Cho
American Journal of Neuroradiology Oct 2010, 31 (9) 1699-1706; DOI: 10.3174/ajnr.A2161

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Differentiation among Glioblastoma Multiforme, Solitary Metastatic Tumor, and Lymphoma Using Whole-Tumor Histogram Analysis of the Normalized Cerebral Blood Volume in Enhancing and Perienhancing Lesions
J.H. Ma, H.S. Kim, N.-J. Rim, S.-H. Kim, K.-G. Cho
American Journal of Neuroradiology Oct 2010, 31 (9) 1699-1706; DOI: 10.3174/ajnr.A2161
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  • Discrimination between Glioblastoma and Solitary Brain Metastasis: Comparison of Inflow-Based Vascular-Space-Occupancy and Dynamic Susceptibility Contrast MR Imaging
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