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Research ArticleBrain
Open Access

Using Quantitative CT Perfusion for Evaluation of Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid Hemorrhage

P.C. Sanelli, I. Ugorec, C.E. Johnson, J. Tan, A.Z. Segal, M. Fink, L.A. Heier, A.J. Tsiouris, J.P. Comunale, M. John, P.E. Stieg, R.D. Zimmerman and A.I. Mushlin
American Journal of Neuroradiology December 2011, 32 (11) 2047-2053; DOI: https://doi.org/10.3174/ajnr.A2693
P.C. Sanelli
aFrom the Departments of Radiology (P.C.S., C.E.J., L.A.H., A.J.T., J.P.C., M.J., R.D.Z.)
bPublic Health (P.C.S., A.I.M.)
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I. Ugorec
fDepartment of Neurology (I.U.), Atlantic Neurosurgical Specialists, Morristown, New Jersey
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C.E. Johnson
aFrom the Departments of Radiology (P.C.S., C.E.J., L.A.H., A.J.T., J.P.C., M.J., R.D.Z.)
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J. Tan
gDepartment of Internal Medicine (J.T.), Kettering Medical Center, New York, New York.
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A.Z. Segal
cNeurology (A.Z.S., M.F.)
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M. Fink
cNeurology (A.Z.S., M.F.)
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L.A. Heier
aFrom the Departments of Radiology (P.C.S., C.E.J., L.A.H., A.J.T., J.P.C., M.J., R.D.Z.)
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A.J. Tsiouris
aFrom the Departments of Radiology (P.C.S., C.E.J., L.A.H., A.J.T., J.P.C., M.J., R.D.Z.)
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J.P. Comunale
aFrom the Departments of Radiology (P.C.S., C.E.J., L.A.H., A.J.T., J.P.C., M.J., R.D.Z.)
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M. John
aFrom the Departments of Radiology (P.C.S., C.E.J., L.A.H., A.J.T., J.P.C., M.J., R.D.Z.)
dDivision of Biostatistics (M.J.), Department of Public Health;
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P.E. Stieg
eDepartment of Neurological Surgery (P.E.S.), New York-Presbyterian Hospital/Weill Cornell Medical College, New York, New York
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R.D. Zimmerman
aFrom the Departments of Radiology (P.C.S., C.E.J., L.A.H., A.J.T., J.P.C., M.J., R.D.Z.)
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A.I. Mushlin
bPublic Health (P.C.S., A.I.M.)
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Data supplements

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    Files in this Data Supplement:

    • Online Appendix, Tables and Figures (PDF) -

      Appendix: See PDF

      Online Table 1: Imaging characteristics of the study population and subgroup

      Online Table 2: Quantitative analysis of CTP parameters for the study population and subgroup

      Online Figure 1: Flow diagram for the reference standard. Note that the assignment of patients in the study by the reference standard at each level is in parentheses.

      Online Figure 2: Flow diagram for patient enrollment.

      Online Figure 3: A 30-year-old woman presented with acute SAH and underwent coil embolization of a left middle cerebral artery (MCA) ruptured aneurysm. The patient developed new right-sided upper extremity weakness on day 7. A, Noncontrast CT of the head demonstrates minimal evolving SAH in the sulci (arrows). There is no new hemorrhage, infarction, or hydrocephalus to indicate another cause for the symptoms. B, The CTP MTT map demonstrates prolongation (red) in the transit time involving the left anterior and MCA territories (arrows). C, The CTP CBF map reveals matched areas of reduced (blue) cortical blood flow (arrows). D, The CTP CBV map has symmetric blood volume without a notable perfusion deficit. E, DSA anteroposterior view with injection of the left internal carotid artery performed on day 7 demonstrates marked narrowing of the ACA and MCA (arrows), representing severe vasospasm.
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American Journal of Neuroradiology: 32 (11)
American Journal of Neuroradiology
Vol. 32, Issue 11
1 Dec 2011
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Using Quantitative CT Perfusion for Evaluation of Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid Hemorrhage
P.C. Sanelli, I. Ugorec, C.E. Johnson, J. Tan, A.Z. Segal, M. Fink, L.A. Heier, A.J. Tsiouris, J.P. Comunale, M. John, P.E. Stieg, R.D. Zimmerman, A.I. Mushlin
American Journal of Neuroradiology Dec 2011, 32 (11) 2047-2053; DOI: 10.3174/ajnr.A2693

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Using Quantitative CT Perfusion for Evaluation of Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid Hemorrhage
P.C. Sanelli, I. Ugorec, C.E. Johnson, J. Tan, A.Z. Segal, M. Fink, L.A. Heier, A.J. Tsiouris, J.P. Comunale, M. John, P.E. Stieg, R.D. Zimmerman, A.I. Mushlin
American Journal of Neuroradiology Dec 2011, 32 (11) 2047-2053; DOI: 10.3174/ajnr.A2693
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  • Prospective Multicenter Study of Changes in MTT after Aneurysmal SAH and Relationship to Delayed Cerebral Ischemia in Patients with Good- and Poor-Grade Admission Status
  • Bedside cerebral microdialysis monitoring of delayed cerebral hypoperfusion in comatose patients with poor grade aneurysmal subarachnoid haemorrhage
  • Application of Blood-Brain Barrier Permeability Imaging in Global Cerebral Edema
  • Evaluating Blood-Brain Barrier Permeability in Delayed Cerebral Infarction after Aneurysmal Subarachnoid Hemorrhage
  • Cost-Effectiveness of CT Angiography and Perfusion Imaging for Delayed Cerebral Ischemia and Vasospasm in Aneurysmal Subarachnoid Hemorrhage
  • CT Perfusion for Detection of Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis
  • Appropriate Use of CT Perfusion following Aneurysmal Subarachnoid Hemorrhage: A Bayesian Analysis Approach
  • Does the Location of the Arterial Input Function Affect Quantitative CTP in Patients with Vasospasm?
  • Effects of Increased Image Noise on Image Quality and Quantitative Interpretation in Brain CT Perfusion
  • Early Perfusion Computerized Tomography Imaging as a Radiographic Surrogate for Delayed Cerebral Ischemia and Functional Outcome After Subarachnoid Hemorrhage
  • Evaluating CT Perfusion Using Outcome Measures of Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage
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