Abstract
SUMMARY: Hemorrhagic transformation is a serious potential complication of ischemic stroke with damage to the BBB as one of the contributing mechanisms. BBB permeability measurements extracted from PCT by using the Patlak model can provide a valuable assessment of the extent of BBB damage. Unfortunately, Patlak assumptions require extended PCT acquisition, increasing the risk of motion artifacts. A necessary correction is presented for obtaining accurate BBB permeability measurements from first-pass PCT.
Abbreviations
- ACA
- anterior cerebral artery
- AIF
- arterial input function
- BBB
- blood-brain barrier
- BBBP
- blood-brain barrier permeability
- CBF
- cerebral blood flow
- CBV
- cerebral blood volume
- CI
- confidence interval
- CTA
- CT angiography
- FLAIR
- fluid-attenuated inversion recovery
- GEE
- generalized estimating equations
- MCA
- middle cerebral artery
- √MSE
- root mean squared errors
- MSE
- mean squared error
- MTT
- mean transit time
- NCCT
- noncontrast CT
- PCA
- posterior cerebral artery
- PCT
- perfusion CT
- PET
- positron-emission tomography
- RIF
- region input function
- rtPA
- recombinant tissue plasminogen activator
- TTP
- time to peak
- Copyright © American Society of Neuroradiology
Indicates open access to non-subscribers at www.ajnr.org