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Review ArticleReview Article
Open Access

Perfusion CT Imaging of Brain Tumors: An Overview

R. Jain
American Journal of Neuroradiology October 2011, 32 (9) 1570-1577; DOI: https://doi.org/10.3174/ajnr.A2263
R. Jain
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Abstract

SUMMARY: Perfusion imaging of brain tumors has been performed by using various tracer and nontracer modalities and can provide additional physiologic and hemodynamic information, which is not available with routine morphologic imaging. Tumor vascular perfusion parameters obtained by using CT or MR perfusion have been used for tumor grading, prognosis, and treatment response in addition to differentiating treatment/radiation effects and non-neoplastic lesions from neoplasms. This article is an overview of the utility of PCT for assessment of brain tumors and describes the technique, its advantages, and limitations.

Abbreviations

BBB
blood-brain barrier
CBF
cerebral blood flow
CBV
cerebral blood volume
DSC
dynamic susceptibility contrast
FDG-PET
fluorodeoxyglucose–positron-emission tomography
Ktrans
volume transfer coefficient
MRI
MR imaging
MTT
mean transit time
MVCP
microvascular cellular proliferation
MVD
microvascular density
PCT
perfusion CT
PS
permeability surface-area product
rCBV
regional cerebral blood flow
ROI
region of interest
rPSR
relative percentage signal recovery
SDF-1
stromal derived factor-1
TDL
tumefactive demyelinating lesion
TVA
total vascular area
VEGF
vascular endothelial growth factor
WHO
World Health Organization
  • © 2011 by American Journal of Neuroradiology

Indicates open access to non-subscribers at www.ajnr.org

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American Journal of Neuroradiology: 32 (9)
American Journal of Neuroradiology
Vol. 32, Issue 9
1 Oct 2011
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Perfusion CT Imaging of Brain Tumors: An Overview
R. Jain
American Journal of Neuroradiology Oct 2011, 32 (9) 1570-1577; DOI: 10.3174/ajnr.A2263

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Perfusion CT Imaging of Brain Tumors: An Overview
R. Jain
American Journal of Neuroradiology Oct 2011, 32 (9) 1570-1577; DOI: 10.3174/ajnr.A2263
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  • Article
    • Abstract
    • Abbreviations
    • In Vivo Perfusion Imaging versus Histopathology
    • Perfusion Parameters and Their Importance
    • PCT Technique
    • Relationship between Glioma Grade and PCT Parameters
    • Heterogeneity of Glioma Angiogenesis and Perfusion Imaging
    • Role of PCT in Differentiating Recurrent Tumor from Radiation Necrosis
    • Differentiating Gliomas from Other Non-Neoplastic Lesions and from Lymphomas
    • Advantages and Limitations of PCT for Brain Tumor Assessment
    • Conclusions
    • References
  • Figures & Data
  • Info & Metrics
  • References
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Cited By...

  • An Antibody-Tumor Necrosis Factor Fusion Protein that Synergizes with Oxaliplatin for Treatment of Colorectal Cancer
  • An antibody-tumor necrosis factor fusion protein that synergizes with oxaliplatin for treatment of colorectal cancer
  • Clinical Value of Vascular Permeability Estimates Using Dynamic Susceptibility Contrast MRI: Improved Diagnostic Performance in Distinguishing Hypervascular Primary CNS Lymphoma from Glioblastoma
  • Whole-brain Volume Perfusion Computed Tomography: Acquisition Techniques and Radiation Dose
  • Glioma Angiogenesis and Perfusion Imaging: Understanding the Relationship between Tumor Blood Volume and Leakiness with Increasing Glioma Grade
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