Article Figures & Data
Figures
- Fig 1.
Representative angiograms from each group at 12-month follow-up. A, Subject from the single-PED group. B, Subject from double-PED group. C, Subject from triple-PED group. In each case, the DSA images show that the lumbar arteries covered by the device remain patent. The yellow arrows indicate both ends of the devices, and the dashed yellow arrows indicate the lumbar arteries.
- Fig 2.
Representative photomicrographs from each group at 12 months. A, Subject from the single-PED group with minimal neointima hyperplasia (H&E, original magnification ×25). B and C, Subject from double- and triple-PED groups, respectively, with neointima thicker than that in A. However, the stenosis area was mild, and the aortas are widely patent (H&E, original magnification ×12.5).
- Fig 3.
Photomicrographs of same subjects as in Fig 1 showing the lumbar artery origins. A, Subject from the single PED group with device struts across 2 lumbar arteries. The neointima crossing the ostia of lumbar arteries is discontinuous (arrows); thus, the lumbar arteries are patent (H&E, original magnification ×25). B and C, Subject from double- and triple-PED groups, respectively, with neointima partially covering the ostia of lumbar artery branches. However, this neointima is also discontinuous (arrow); thus, the branch vessels are patent (H&E, original magnification ×40).
Tables
Morphometric measurementsa
Treatment Group NIT (mm) Stenosis (%) Medial Area (mm2) 6 m 12 m 6 m 12 m 6 m 12 m Single PED 0.1 ± 0.0 0.1 ± 0.0 8.4 ± 0.6 6.7 ± 1.3 1.3 ± 0.4 1.0 ± 0.1 Double PED 0.2 ± 0.0 0.1 ± 0.0 13.0 ± 1.1 10.4 ± 0.8 0.9 ± 0.1 0.9 ± 0.1 Triple PED 0.2 ± 0.0 0.2 ± 0.0 15.4 ± 1.0 18.0 ± 1.9 1.0 ± 0.1 0.8 ± 0.1 -
Note:—NIT indicates neointimal thickness.
-
↵a Data are represented as mean ± SD. NIT is decreased from 6 to 12 months in the double-PED group (P = .0092); there were no significant differences for the single- and triple-PED groups (P = 1.0). At 6 months, the NIT values in the double (P = .0049) and triple (P = .0012) groups are significantly higher than those in the single group. There are no significant differences between double- and triple-PED groups at this time point (P = .4191). At 12 months, the NIT in the triple-PED group is significantly higher than in single- and double-PED groups (P < .001); there are no significant differences between single and double groups (P = 1.0). When the percentage stenosis is examined, there is no difference between 6 and 12 months for the single, double, or triple PED. At 6 months, the percentage stenoses in double and triple groups are both higher than that in the single group (P < .005). There are no significant differences between the double and triple groups (P = .2237). At 12 months, the percentage stenoses for the double (P = .0026) and triple groups (P < .0001) are higher than that in the single group; the percentage stenosis in the triple group is also higher than that in the double group (P < .0001). There are no significant differences in the medial area either for PED groups with time or for PED groups that were examined within each time point.
-
In this issue
Jump to section
Related Articles
Cited By...
- Predictors of the Effects of Flow Diversion in Very Large and Giant Aneurysms
- Long-term visual outcome in patients treated by flow diversion for carotid-ophthalmic aneurysms
- Use of flow diverters in the treatment of unruptured saccular aneurysms of the anterior cerebral artery
- Pipeline embolization device for the treatment of vertebral artery aneurysms: the fate of covered branch vessels
- Flow diversion treatment of complex bifurcation aneurysms beyond the circle of Willis: a single-center series with special emphasis on covered cortical branches and perforating arteries
- Posterior Inferior Cerebellar Artery Patency after Flow-Diverting Stent Treatment
- A New Aneurysm Occlusion Classification after the Impact of Flow Modification
- Flow diverter stents for unruptured saccular anterior circulation perforating artery aneurysms: safety, efficacy, and short-term follow-up
- Extra-Aneurysmal Flow Modification Following Pipeline Embolization Device Implantation: Focus on Regional Branches, Perforators, and the Parent Vessel
- Small Pipes: Preliminary Experience with 3-mm or Smaller Pipeline Flow-Diverting Stents for Aneurysm Repair prior to Regulatory Approval
- Visual Outcomes with Flow-Diverter Stents Covering the Ophthalmic Artery for Treatment of Internal Carotid Artery Aneurysms
- Building Multidevice Pipeline Constructs of Favorable Metal Coverage: A Practical Guide
- Pipeline Embolization Device in Aneurysmal Subarachnoid Hemorrhage