Abstract
SUMMARY: Central nervous system toxicity of 5-FU could show various manifestations, such as decreased alertness, disorientation, and agitation. It is generally accepted that lesions of 5-FU encephalopathy are mainly in the deep cerebral white matter and corpus callosum on MR imaging. Here we describe a case of 5-FU encephalopathy in gastric cancer with an atypical reversible diffusion-restricted lesion on MR imaging, showing bilateral basal ganglia, thalami, and parasagittal frontal cortex involvement on diffusion and T2-weighted imaging.
ABBREVIATIONS:
- BUN
- blood urea nitrogen
- CRF
- chronic renal failure
- DPD
- dihydropyrimidine dehydrogenase
- 5-FU
- 5-fluorouracil
- PT/INR
- prothrombin time/international normalized ratio
- © 2012 by American Journal of Neuroradiology