Association of CT Perfusion Parameters with Hemorrhagic Transformation in Acute Ischemic Stroke

REFERENCES

1. 1.↵
   1. Lloyd-Jones D,
   2. Adams RJ,
   3. Brown TM,
   4. et al

   . Heart disease and stroke statistics: 2010 update—a report from the American Heart Association. Circulation 2010;121:e46–e215

   FREE Full Text
2. 2.↵
   1. Ginsberg MD,
   2. Bogousslavsky J

   1. Asplund K,
   2. Stegmayr B,
   3. Peltonen M

   . From the twentieth to the twenty-first century: a public health perspective on stroke. In: Ginsberg MD, Bogousslavsky J , eds. Cerebrovascular Disease Pathophysiology, Diagnosis, and Management. Vol 2. Malden, Massachusetts: Blackwell Science; 1998
3. 3.↵
   World Health Organization. The top 10 causes of death: updated 2011. http://www.who.int/mediacentre/factsheets/fs310/en/index.html. Accessed March 12, 2012
4. 4.↵
   Incidence and Prevalence: 2006 Chart Book on Cardiovascular and Lung Diseases. Bethesda, Maryland: National Institutes of Health, National Heart Lung and Blood institute; 2006
5. 5.↵
   Tissue plasminogen activator for acute ischemic stroke: the National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med 1995;333:1581–87

   CrossRefPubMedWeb of Science
6. 6.↵
   1. Hacke W,
   2. Kaste M,
   3. Bluhmki E,
   4. et al

   . Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008;359:1317–29

   CrossRefPubMedWeb of Science
7. 7.↵
   1. Wahlgren N,
   2. Ahmed N,
   3. Davalos A,
   4. et al

   . Thrombolysis with alteplase 3–4.5 h after acute ischaemic stroke (SITS-ISTR): an observational study. Lancet 2008;372:1303–09

   CrossRefPubMedWeb of Science
8. 8.↵
   1. Ahmed N,
   2. Wahlgren N,
   3. Grond M,
   4. et al

   . Implementation and outcome of thrombolysis with alteplase 3–4.5 h after an acute stroke: an updated analysis from SITS-ISTR. Lancet Neurol 2010;9:866–74

   CrossRefPubMedWeb of Science
9. 9.↵
   1. Lees KR,
   2. Bluhmki E,
   3. von Kummer R,
   4. et al

   . Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet 2010;375:1695–703

   CrossRefPubMedWeb of Science
10. 10.↵
    1. Jaillard A,
    2. Cornu C,
    3. Durieux A,
    4. et al

    . Hemorrhagic transformation in acute ischemic stroke: the MAST-E study—MAST-E Group. Stroke 1999;30:1326–32

    Abstract/FREE Full Text
11. 11.↵
    1. Larrue V,
    2. von Kummer RR,
    3. Muller A,
    4. et al

    . Risk factors for severe hemorrhagic transformation in ischemic stroke patients treated with recombinant tissue plasminogen activator: a secondary analysis of the European-Australasian Acute Stroke Study (ECASS II). Stroke 2001;32:438–41

    Abstract/FREE Full Text
12. 12.↵
    1. Kerenyi L,
    2. Kardos L,
    3. Szasz J,
    4. et al

    . Factors influencing hemorrhagic transformation in ischemic stroke: a clinicopathological comparison. Eur J Neurol 2006;13:1251–55

    CrossRefPubMed
13. 13.↵
    1. Kidwell CS,
    2. Saver JL,
    3. Carneado J,
    4. et al

    . Predictors of hemorrhagic transformation in patients receiving intra-arterial thrombolysis. Stroke 2002;33:717–24

    Abstract/FREE Full Text
14. 14.↵
    1. Dzialowski I,
    2. Pexman JH,
    3. Barber PA,
    4. et al

    . Asymptomatic hemorrhage after thrombolysis may not be benign: prognosis by hemorrhage type in the Canadian alteplase for stroke effectiveness study registry. Stroke 2007;38:75–79

    Abstract/FREE Full Text
15. 15.↵
    1. Fiorelli M,
    2. Bastianello S,
    3. von Kummer R,
    4. et al

    . Hemorrhagic transformation within 36 hours of a cerebral infarct: relationships with early clinical deterioration and 3-month outcome in the European Cooperative Acute Stroke Study I (ECASS I) cohort. Stroke 1999;30:2280–84

    Abstract/FREE Full Text
16. 16.↵
    1. Larrue V,
    2. von Kummer R,
    3. del Zoppo G,
    4. et al

    . Hemorrhagic transformation in acute ischemic stroke: potential contributing factors in the European Cooperative Acute Stroke Study. Stroke 1997;28:957–60

    Abstract/FREE Full Text
17. 17.↵
    1. Dowlatshahi D,
    2. O'Donnell M,
    3. Sharma M

    . Possible influence of stroke etiology on hemorrhagic transformation following thrombolysis in warfarin-treated patients. Arch Neurol 2010;67:1413, author reply 1414
18. 18.↵
    1. Castellanos M,
    2. Leira R,
    3. Serena J,
    4. et al

    . Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke. Stroke 2003;34:40–46

    Abstract/FREE Full Text
19. 19.↵
    1. Toni D,
    2. Fiorelli M,
    3. Bastianello S,
    4. et al

    . Hemorrhagic transformation of brain infarct: predictability in the first 5 hours from stroke onset and influence on clinical outcome. Neurology 1996;46:341–45

    CrossRef
20. 20.↵
    1. Alexandrov AV,
    2. Black SE,
    3. Ehrlich LE,
    4. et al

    . Predictors of hemorrhagic transformation occurring spontaneously and on anticoagulants in patients with acute ischemic stroke. Stroke 1997;28:1198–202

    Abstract/FREE Full Text
21. 21.↵
    1. Knight RA,
    2. Barker PB,
    3. Fagan SC,
    4. et al

    . Prediction of impending hemorrhagic transformation in ischemic stroke using magnetic resonance imaging in rats. Stroke 1998;29:144–51

    Abstract/FREE Full Text
22. 22.↵
    1. Tong DC,
    2. Adami A,
    3. Moseley ME,
    4. et al

    . Prediction of hemorrhagic transformation following acute stroke: role of diffusion- and perfusion-weighted magnetic resonance imaging. Arch Neurol 2001;58:587–93

    CrossRefPubMed
23. 23.↵
    1. Hom J,
    2. Dankbaar JW,
    3. Soares BP,
    4. et al

    . Blood-brain barrier permeability assessed by perfusion CT predicts symptomatic hemorrhagic transformation and malignant edema in acute ischemic stroke. AJNR Am J Neuroradiol 2011;32:41–48

    Abstract/FREE Full Text
24. 24.↵
    1. Hacke W,
    2. Kaste M,
    3. Fieschi C,
    4. et al

    . Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke: the European Cooperative Acute Stroke Study (ECASS). JAMA 1995;274:1017–25

    CrossRefPubMedWeb of Science
25. 25.↵
    1. Hacke W,
    2. Kaste M,
    3. Fieschi C,
    4. et al

    . Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II): Second European-Australasian Acute Stroke Study Investigators. Lancet 1998;352:1245–51

    CrossRefPubMedWeb of Science
26. 26.↵
    1. Parsons MW,
    2. Pepper EM,
    3. Bateman GA,
    4. et al

    . Identification of the penumbra and infarct core on hyperacute noncontrast and perfusion CT. Neurology 2007;68:730–36

    CrossRef
27. 27.↵
    1. Aviv RI,
    2. d'Esterre CD,
    3. Murphy BD,
    4. et al

    . Hemorrhagic transformation of ischemic stroke: prediction with CT perfusion. Radiology 2009;250:867–77

    CrossRefPubMedWeb of Science
28. 28.↵
    1. Saver JL

    . Hemorrhage after thrombolytic therapy for stroke: the clinically relevant number needed to harm. Stroke 2007;38:2279–83

    Abstract/FREE Full Text
29. 29.↵
    1. Broderick JP,
    2. Hagen T,
    3. Brott T,
    4. et al

    . Hyperglycemia and hemorrhagic transformation of cerebral infarcts. Stroke 1995;26:484–87

    Abstract/FREE Full Text
30. 30.↵
    1. Bowes MP,
    2. Zivin JA,
    3. Thomas GR,
    4. et al

    . Acute hypertension, but not thrombolysis, increases the incidence and severity of hemorrhagic transformation following experimental stroke in rabbits. Exp Neurol 1996;141:40–46

    CrossRefPubMedWeb of Science
31. 31.↵
    1. Ko Y,
    2. Park JH,
    3. Yang MH,
    4. et al

    . The significance of blood pressure variability for the development of hemorrhagic transformation in acute ischemic stroke. Stroke 2010;41:2512–18

    Abstract/FREE Full Text
32. 32.↵
    1. Prodan CI,
    2. Stoner JA,
    3. Cowan LD,
    4. et al

    . Lower coated-platelet levels are associated with early hemorrhagic transformation in patients with non-lacunar brain infarction. J Thromb Haemost 2010;8:1185–90

    CrossRefPubMed
33. 33.↵
    1. Okada Y,
    2. Yamaguchi T,
    3. Minematsu K,
    4. et al

    . Hemorrhagic transformation in cerebral embolism. Stroke 1989;20:598–603

    Abstract/FREE Full Text
34. 34.↵
    1. Rowley HA

    . Extending the time window for thrombolysis: evidence from acute stroke trials. Neuroimaging Clin N Am 2005;15:575–87, x

    CrossRefPubMed
35. 35.↵
    1. Ueda T,
    2. Hatakeyama T,
    3. Kumon Y,
    4. et al

    . Evaluation of risk of hemorrhagic transformation in local intra-arterial thrombolysis in acute ischemic stroke by initial SPECT. Stroke 1994;25:298–303

    Abstract/FREE Full Text
36. 36.↵
    1. Seki H,
    2. Yoshimoto T,
    3. Ogawa A,
    4. et al

    . Hemodynamics in hemorrhagic infarction: an experimental study. Stroke 1985;16:647–51

    Abstract/FREE Full Text
37. 37.↵
    1. Gupta R,
    2. Yonas H,
    3. Gebel J,
    4. et al

    . Reduced pretreatment ipsilateral middle cerebral artery cerebral blood flow is predictive of symptomatic hemorrhage post-intra-arterial thrombolysis in patients with middle cerebral artery occlusion. Stroke 2006;37:2526–30

    Abstract/FREE Full Text
38. 38.↵
    1. Souza LC,
    2. Payabvash S,
    3. Wang Y,
    4. et al

    . Admission CT perfusion is an independent predictor of hemorrhagic transformation in acute stroke with similar accuracy to DWI. Cerebrovasc Dis 2012;33:8–15

    CrossRefPubMed
39. 39.↵
    1. Lin K,
    2. Zink WE,
    3. Tsiouris AJ,
    4. et al

    . Risk assessment of hemorrhagic transformation of acute middle cerebral artery stroke using multimodal CT. J Neuroimaging 2012;22:160–66

    CrossRefPubMed
40. 40.↵
    1. Sims J,
    2. Schwamm LH

    . The evolving role of acute stroke imaging in intravenous thrombolytic therapy: patient selection and outcomes assessment. Neuroimaging Clin N Am 2005;15:421–40, xii

    CrossRefPubMed
41. 41.↵
    1. Schellinger PD

    . The evolving role of advanced MR imaging as a management tool for adult ischemic stroke: a Western-European perspective. Neuroimaging Clin N Am 2005;15:245–58, ix

    CrossRefPubMed
42. 42.↵
    1. Thornhill RE,
    2. Chen S,
    3. Rammo W,
    4. et al

    . Contrast-enhanced MR imaging in acute ischemic stroke: T2* measures of blood-brain barrier permeability and their relationship to T1 estimates and hemorrhagic transformation. AJNR Am J Neuroradiol 2010;31:1015–22

    Abstract/FREE Full Text
43. 43.↵
    1. Wintermark M,
    2. Reichhart M,
    3. Thiran JP,
    4. et al

    . Prognostic accuracy of cerebral blood flow measurement by perfusion computed tomography, at the time of emergency room admission, in acute stroke patients. Ann Neurol 2002;51:417–32

    CrossRefPubMedWeb of Science