Abstract
SUMMARY: In the context of neurointerventional procedures, clopidogrel hyper-responsiveness has been associated with hemorrhage; on the other hand, clopidogrel resistance has been associated with thromboembolism. This might seem to make a compelling argument in favor of routine platelet testing. Our reading of the literature leads us to conclude that routine platelet testing in neurointerventional procedures is not, unfortunately, ready for prime time.
ABBREVIATIONS:
- CREST
- Clopidogrel Effect on Platelet Reactivity in Patients with Stent Thrombosis
- GRAVITAS
- Gauging Responsiveness with a VerifyNow Assay
- OASIS-7
- Optimal Antiplatelet Strategy for Interventions
- PCI
- percutaneous coronary intervention
- POPULAR
- Point-of-Care Platelet Function Assays Predict Clinical Outcomes in Clopidogrel pre-treated patients undergoing elective PCI
- TRIGGER-PCI
- Testing Platelet Reactivity in Patients Undergoing Elective Stent Placement on Clopidogrel to Guide Alternate Therapy with Prasugrel.
- © 2013 by American Journal of Neuroradiology