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Research ArticleTechnical Note
Open Access

The Kety-Schmidt Technique for Quantitative Perfusion and Oxygen Metabolism Measurements in the MR Imaging Environment

J.J. Lee, W.J. Powers, C.B. Faulkner, P.J. Boyle and C.P. Derdeyn
American Journal of Neuroradiology September 2013, 34 (9) E100-E102; DOI: https://doi.org/10.3174/ajnr.A3270
J.J. Lee
aFrom the Mallinckrodt Institute of Radiology (J.J.L., C.P.D.)
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W.J. Powers
dDepartment of Neurology (W.J.P.), University of North Carolina School of Medicine, Chapel Hill, North Carolina
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C.B. Faulkner
bDivision of Comparative Medicine (C.B.F.)
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P.J. Boyle
eDepartment of Medicine (P.J.B.), University of New Mexico, Albuquerque, New Mexico.
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C.P. Derdeyn
aFrom the Mallinckrodt Institute of Radiology (J.J.L., C.P.D.)
cDepartments of Neurology and Neurological Surgery (C.P.D.), Washington University School of Medicine, St. Louis, Missouri
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Abstract

SUMMARY: The Kety-Schmidt technique provides quantitative measurement of whole-brain CBF. CBF is measured as the area between the arterial and venous washout curves of a diffusible tracer. Oxygen extraction and metabolism may be calculated from arterial and venous samples. In this report, we present a method for performing these measurements in an MR imaging environment. This technique could be useful for validation of MR imaging methods of hemodynamic and metabolic measurements in humans.

ABBREVIATIONS:

CMRO2
cerebral metabolic rate for oxygen consumption
IM
intramuscularly
NDIR
nondispersive infrared
OEF
oxygen extraction fraction
  • © 2013 by American Journal of Neuroradiology

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American Journal of Neuroradiology: 34 (9)
American Journal of Neuroradiology
Vol. 34, Issue 9
1 Sep 2013
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The Kety-Schmidt Technique for Quantitative Perfusion and Oxygen Metabolism Measurements in the MR Imaging Environment
J.J. Lee, W.J. Powers, C.B. Faulkner, P.J. Boyle, C.P. Derdeyn
American Journal of Neuroradiology Sep 2013, 34 (9) E100-E102; DOI: 10.3174/ajnr.A3270

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The Kety-Schmidt Technique for Quantitative Perfusion and Oxygen Metabolism Measurements in the MR Imaging Environment
J.J. Lee, W.J. Powers, C.B. Faulkner, P.J. Boyle, C.P. Derdeyn
American Journal of Neuroradiology Sep 2013, 34 (9) E100-E102; DOI: 10.3174/ajnr.A3270
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