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Research ArticleInterventional
Open Access

A Novel Flow-Diverting Device (Tubridge) for the Treatment of 28 Large or Giant Intracranial Aneurysms: A Single-Center Experience

Y. Zhou, P.-F. Yang, Y.-B. Fang, Y. Xu, B. Hong, W.-Y. Zhao, Q. Li, R. Zhao, Q.-H. Huang and J.-M. Liu
American Journal of Neuroradiology December 2014, 35 (12) 2326-2333; DOI: https://doi.org/10.3174/ajnr.A3925
Y. Zhou
aFrom the Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, P.R. China.
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P.-F. Yang
aFrom the Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, P.R. China.
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Y.-B. Fang
aFrom the Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, P.R. China.
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Y. Xu
aFrom the Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, P.R. China.
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B. Hong
aFrom the Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, P.R. China.
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W.-Y. Zhao
aFrom the Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, P.R. China.
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Q. Li
aFrom the Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, P.R. China.
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R. Zhao
aFrom the Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, P.R. China.
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Q.-H. Huang
aFrom the Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, P.R. China.
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J.-M. Liu
aFrom the Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai, P.R. China.
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  • Fig 1.
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    Fig 1.

    Right internal carotid artery digital subtraction angiography (A) revealed a 13-mm wide-neck cavernous segment aneurysm. A Tubridge flow diverter was deployed into the parent artery, aimed at covering the aneurysmal neck, but postoperative DynaCT revealed that the flow diverter was not fully opened (B, white arrow). Cross-sectional image (C, white arrow) and 3D reconstruction (D, white arrow) show poor opening of the device. Fortunately, 18-month follow-up angiography reveals that the aneurysm is stable with a patent artery (E).

  • Fig 2.
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    Fig 2.

    Right internal carotid artery digital subtraction angiography and 3D reconstruction (A–C) reveal a giant cavernous segment aneurysm of approximately 25.3 mm. The microcatheter is delivered across the aneurysmal neck (D), and 1 Tubridge flow diverter is deployed. Postoperative angiography reveals a disrupted inflow jet, slow flow, and flow reduction (E and F). The 23-month follow-up angiography reveals that the aneurysm is completely occluded (G). H, The black arrow points to the patent covered ophthalmic artery during follow-up compared with the preoperative image. MR imaging follow-up shows shrinkage of the aneurysm (black arrow).

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    Fig 3.

    Left internal carotid artery digital subtraction angiography of an aneurysm treated with a Tubridge flow diverter combined with coils, which results in partial occlusion of the aneurysm (A). DynaCT reconstruction reveals full opening of the flow diverter (B).The 18-month follow-up angiography reveals that the aneurysm has improved, and only a neck remnant is observed (C, black arrow).

Tables

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    Table 1:

    Clinical, angiographic, and follow-up data in 28 patients with 28 large or giant ICA aneurysms

    Characteristics
    Patients (aneurysms) (No.)28 (28)
    Mean age (range) (yr)54.8 (20–73)
    Male/female8:20
    Aneurysm location
    ICA communicating2
    ICA ophthalmic8
    ICA paraclinoid7
    ICA cavernous10
    ICA petrous1
    Presentation
        Asymptomatic6
        Headache11
        Recanalization3
        Oculomotor paralysis7
        Blurred vision3
        Blind1
        Amenorrhea1
    Aneurysm size
        Large (10–15 mm)4
        Very large (15–25 mm)16
        Giant (≥25 mm)8
    • View popup
    Table 2:

    Clinical, angiographic, and follow-up data in 28 patients with 28 large or giant ICA aneurysms

    Treatment
    Treatment strategy
        FD alone10
        FD + loose coiling18
    No. implanted flow diverters
        Two overlapping flow diverters5
        Single flow diverter23
    Technique adverse event
        Poor midstent opening1
    Immediate angiographic results
        Partial occlusion16
        Neck remnant2
        Disrupted inflow jet and slow flow9
        Flow reduction7
        No change3
    Clinical symptoms
        Resolved13
        Improved6
        No change4
        Transient worsening5
        Overall procedure-related morbidity/mortality0/0
    Follow-up angiographic results (n = 25)
        Complete occlusion18 (72%)
        Improvement6 (24%)
        Stable1 (4%)
    • View popup
    Table 3:

    Follow-up angiographic outcome of different treatment modalities

    FD AloneFD Plus CoilingTotal
    Complete occlusion6 (75.0%)12 (70.5%)18 (72.0%)
    Improved to neck remnant1 (12.5%)5 (29.4%)6 (24.0%)
    Unchanged1 (12.5%)01 (2.0%)
    Total81725
    • View popup
    Table 4:

    Structure comparison among different flow diverters

    TypeSize (mm)Braided MicrofilamentsaRadio-Opaque MicrofilamentsFlared EndMetal CoverageRetrievable
    No.Material
    Pipeline3–5.54875% Cobalt chromium and 25% platinumNANo30%–35%Nob
    Silk2.5–548Nickel-titanium alloy4 Platinum wiresYes35%–55%Yes
    Surpass2.5–52.5 mm, 36; 3 and 4 mm, 60; 5 mm, 84Cobalt-chromium12 Platinum wiresNo30%NA
    Tubridge2.5–6.5<3.5 mm, 46; ≥3.5 mm, 62Nickel-titanium alloy2 Platinum-iridium wiresYes30%–35%Yes
    • Note:—NA indicates not applicable.

    • ↵a Braided microfilaments mean those main wires excluding microfilaments especially for radio-opaque usage.

    • ↵b The Pipeline Embolization Device is not retrievable, but at any point up to final deployment, it may be captured and removed from the body.

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American Journal of Neuroradiology: 35 (12)
American Journal of Neuroradiology
Vol. 35, Issue 12
1 Dec 2014
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A Novel Flow-Diverting Device (Tubridge) for the Treatment of 28 Large or Giant Intracranial Aneurysms: A Single-Center Experience
Y. Zhou, P.-F. Yang, Y.-B. Fang, Y. Xu, B. Hong, W.-Y. Zhao, Q. Li, R. Zhao, Q.-H. Huang, J.-M. Liu
American Journal of Neuroradiology Dec 2014, 35 (12) 2326-2333; DOI: 10.3174/ajnr.A3925

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A Novel Flow-Diverting Device (Tubridge) for the Treatment of 28 Large or Giant Intracranial Aneurysms: A Single-Center Experience
Y. Zhou, P.-F. Yang, Y.-B. Fang, Y. Xu, B. Hong, W.-Y. Zhao, Q. Li, R. Zhao, Q.-H. Huang, J.-M. Liu
American Journal of Neuroradiology Dec 2014, 35 (12) 2326-2333; DOI: 10.3174/ajnr.A3925
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  • Parent Artery Reconstruction for Large or Giant Cerebral Aneurysms Using the Tubridge Flow Diverter: A Multicenter, Randomized, Controlled Clinical Trial (PARAT)
  • Cerebral aneurysm treatment: modern neurovascular techniques
  • Republished: Late recurrence of a completely occluded large intracranial aneurysm treated with a Tubridge flow diverter
  • Virtual-versus-Real Implantation of Flow Diverters: Clinical Potential and Influence of Vascular Geometry
  • Late recurrence of a completely occluded large intracranial aneurysm treated with a Tubridge flow diverter
  • Initial Experience with p64: A Novel Mechanically Detachable Flow Diverter for the Treatment of Intracranial Saccular Sidewall Aneurysms
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