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Research ArticleBrain
Open Access

Assessment of Angiographic Vascularity of Meningiomas with Dynamic Susceptibility Contrast-Enhanced Perfusion-Weighted Imaging and Diffusion Tensor Imaging

C.H. Toh, K.-C. Wei, C.N. Chang, Y.-W. Peng, S.-H. Ng, H.-F. Wong and C.-P. Lin
American Journal of Neuroradiology February 2014, 35 (2) 263-269; DOI: https://doi.org/10.3174/ajnr.A3651
C.H. Toh
aFrom the Departments of Medical Imaging and Intervention (C.H.T, Y.-W.P., S.-H.N, H.-F.W.)
cDepartment of Biomedical Imaging and Radiological Sciences (C.H.T., C.-P.L.)
dBrain Connectivity Laboratory (C.H.T, C.-P.L.), Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan.
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K.-C. Wei
bNeurosurgery (K.-C.W., C.N.C.), Chang Gung Memorial Hospital, Linkou and Chang Gung University College of Medicine, Tao-Yuan, Taiwan
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C.N. Chang
bNeurosurgery (K.-C.W., C.N.C.), Chang Gung Memorial Hospital, Linkou and Chang Gung University College of Medicine, Tao-Yuan, Taiwan
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Y.-W. Peng
aFrom the Departments of Medical Imaging and Intervention (C.H.T, Y.-W.P., S.-H.N, H.-F.W.)
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S.-H. Ng
aFrom the Departments of Medical Imaging and Intervention (C.H.T, Y.-W.P., S.-H.N, H.-F.W.)
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H.-F. Wong
aFrom the Departments of Medical Imaging and Intervention (C.H.T, Y.-W.P., S.-H.N, H.-F.W.)
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C.-P. Lin
cDepartment of Biomedical Imaging and Radiological Sciences (C.H.T., C.-P.L.)
dBrain Connectivity Laboratory (C.H.T, C.-P.L.), Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan.
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  • Fig 1.
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    Fig 1.

    Upper panel shows DSA images of 4 different meningiomas, demonstrating grade 0 (A), 1 (B), 2 (C), and 3 (D) angiographic vascularity, respectively. Arrows indicate locations of meningiomas; lower panel shows the corresponding postcontrast MPRAGE images in coronal view.

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    Fig 2.

    Upper panel shows DSA (A), contrast-enhanced MPRAGE (B), FA (C), and CBV (D) images of a meningioma with grade 1 angiographic vascularity; lower panel (E–H) shows the corresponding images from a meningioma with grade 3 angiographic vascularity.

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    Fig 3.

    Scatterplots with regression lines show a correlation (Spearman ρ = 0.891) between CBV and angiographic vascularity (A) and an inverse correlation (Spearman ρ = −0.861) between FA and angiographic vascularity (B). There is no correlation between ADC and angiographic vascularity.

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    Fig 4.

    Boxplots of CBV (A), FA (B), and ADC (C) according to angiographic vascularity.

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    Fig 5.

    ROC curve analysis of the diagnostic performance of CBV and FA in differentiating between low-vascularity and high-vascularity meningiomas.

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    Table 1:

    Comparison of clinical and imaging data between low-vascularity and high-vascularity meningiomas

    GroupLow-Vascularity MeningiomaHigh-Vascularity MeningiomaP Value95% CI
    Sex6 women, 4 men9 women, 13 men.450NA
    Age, y49.7 ± 16.756.7 ± 14.5.237−18.91 to 4.86
    Size, cm5.45 ± 1.695.27 ± 1.57.781−1.08 to 1.42
    CBV5.06 ± 2.0513.97 ± 5.67<.001−12.71 to −5.10
    ADC1.114 ± 0.1071.213 ± 0.258.253−0.27 to 0.07
    FA0.621 ± 0.1060.339 ± 0.147<.0010.17 to 0.38
    • Note:—Data are mean ± standard deviation. Units are × 10−3 mm2/s for ADC values.

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    Table 2:

    ROC analysis of CBV and FA in differentiating meningiomas with high vascularity from those with low vascularity

    ParameterAUC95% CIP ValueCVSENSPE
    CBV0.9910.967–1.015<.0018.2190.9100
    FA0.9340.852–1.016<.0010.42510077
    • Note:—CV indicates cutoff value; SEN, sensitivity; SPE, specificity. Data of sensitivity, specificity, and accuracy are in percentages.

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American Journal of Neuroradiology: 35 (2)
American Journal of Neuroradiology
Vol. 35, Issue 2
1 Feb 2014
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Assessment of Angiographic Vascularity of Meningiomas with Dynamic Susceptibility Contrast-Enhanced Perfusion-Weighted Imaging and Diffusion Tensor Imaging
C.H. Toh, K.-C. Wei, C.N. Chang, Y.-W. Peng, S.-H. Ng, H.-F. Wong, C.-P. Lin
American Journal of Neuroradiology Feb 2014, 35 (2) 263-269; DOI: 10.3174/ajnr.A3651

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Assessment of Angiographic Vascularity of Meningiomas with Dynamic Susceptibility Contrast-Enhanced Perfusion-Weighted Imaging and Diffusion Tensor Imaging
C.H. Toh, K.-C. Wei, C.N. Chang, Y.-W. Peng, S.-H. Ng, H.-F. Wong, C.-P. Lin
American Journal of Neuroradiology Feb 2014, 35 (2) 263-269; DOI: 10.3174/ajnr.A3651
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