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Research ArticleInterventional

Small Pipes: Preliminary Experience with 3-mm or Smaller Pipeline Flow-Diverting Stents for Aneurysm Repair prior to Regulatory Approval

A.R. Martin, J.P. Cruz, C. O'Kelly, M. Kelly, J. Spears and T.R. Marotta
American Journal of Neuroradiology March 2015, 36 (3) 557-561; DOI: https://doi.org/10.3174/ajnr.A4170
A.R. Martin
aFrom the Division of Neurosurgery (A.R.M., J.S.), Department of Surgery
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J.P. Cruz
bDepartment of Radiology (J.P.C., T.R.M.), University of Toronto, Toronto, Ontario, Canada
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C. O'Kelly
cDivision of Neurosurgery (C.O.), Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
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M. Kelly
dDivision of Neurosurgery (M.K.), Department of Surgery, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
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J. Spears
aFrom the Division of Neurosurgery (A.R.M., J.S.), Department of Surgery
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T.R. Marotta
bDepartment of Radiology (J.P.C., T.R.M.), University of Toronto, Toronto, Ontario, Canada
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Abstract

SUMMARY: Flow diversion has become an established treatment option for challenging intracranial aneurysms. The use of small devices of ≤3-mm diameter remains unapproved by major regulatory bodies. A retrospective review of patients treated with Pipeline Embolization Devices of ≤3-mm diameter at 3 Canadian institutions was conducted. Clinical and radiologic follow-up data were collected and reported. Twelve cases were treated with ≥1 Pipeline Embolization Device of ≤3-mm diameter, including 2 with adjunctive coiling, with a median follow-up of 18 months (range, 4–42 months). One patient experienced a posttreatment minor complication (8%) due to an embolic infarct. No posttreatment hemorrhage or delayed complications such as in-stent stenosis/thrombosis were observed. Radiologic occlusion was seen in 9/12 cases (75%) and near-occlusion in 2/12 cases (17%). Intracranial aneurysm treatment with small-diameter flow-diverting stents provided safe and effective aneurysm closure in this small selected sample. These devices should be further studied and considered for regulatory approval.

ABBREVIATIONS:

PED
Pipeline Embolization Device
PICA
posterior inferior cerebellar artery
  • © 2015 by American Journal of Neuroradiology
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American Journal of Neuroradiology: 36 (3)
American Journal of Neuroradiology
Vol. 36, Issue 3
1 Mar 2015
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Small Pipes: Preliminary Experience with 3-mm or Smaller Pipeline Flow-Diverting Stents for Aneurysm Repair prior to Regulatory Approval
A.R. Martin, J.P. Cruz, C. O'Kelly, M. Kelly, J. Spears, T.R. Marotta
American Journal of Neuroradiology Mar 2015, 36 (3) 557-561; DOI: 10.3174/ajnr.A4170

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Small Pipes: Preliminary Experience with 3-mm or Smaller Pipeline Flow-Diverting Stents for Aneurysm Repair prior to Regulatory Approval
A.R. Martin, J.P. Cruz, C. O'Kelly, M. Kelly, J. Spears, T.R. Marotta
American Journal of Neuroradiology Mar 2015, 36 (3) 557-561; DOI: 10.3174/ajnr.A4170
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