Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
    • COVID-19 Content and Resources
  • For Authors
  • About Us
    • About AJNR
    • Editors
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Other Publications
    • ajnr

User menu

  • Subscribe
  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

  • Subscribe
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
    • COVID-19 Content and Resources
  • For Authors
  • About Us
    • About AJNR
    • Editors
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds
Research ArticleResearch Perspectives
Open Access

Imaging Biomarkers in Acute Ischemic Stroke Trials: A Systematic Review

G.W.J. Harston, N. Rane, G. Shaya, S. Thandeswaran, M. Cellerini, F. Sheerin and J. Kennedy
American Journal of Neuroradiology May 2015, 36 (5) 839-843; DOI: https://doi.org/10.3174/ajnr.A4208
G.W.J. Harston
aFrom the Radcliffe Department of Medicine (G.W.J.H., G.S., S.T., J.K.), University of Oxford, Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
N. Rane
bDepartment of Neuroradiology (N.R., M.C., F.S.), Oxford University Hospitals NHS Trust, Oxford, United Kingdom
cNeurointervention Service (N.R.), Royal Melbourne Hospital, Melbourne Health, Victoria, Australia.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G. Shaya
aFrom the Radcliffe Department of Medicine (G.W.J.H., G.S., S.T., J.K.), University of Oxford, Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Thandeswaran
aFrom the Radcliffe Department of Medicine (G.W.J.H., G.S., S.T., J.K.), University of Oxford, Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Cellerini
bDepartment of Neuroradiology (N.R., M.C., F.S.), Oxford University Hospitals NHS Trust, Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
F. Sheerin
bDepartment of Neuroradiology (N.R., M.C., F.S.), Oxford University Hospitals NHS Trust, Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Kennedy
aFrom the Radcliffe Department of Medicine (G.W.J.H., G.S., S.T., J.K.), University of Oxford, Oxford, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • References
  • PDF
Loading

REFERENCES

  1. 1.↵
    1. Wardlaw JM
    . Surrogate outcomes: a cautionary note. Stroke 2009;40:1029–31
    FREE Full Text
  2. 2.↵
    1. Wintermark M,
    2. Albers GW,
    3. Broderick JP, et al
    . Acute Stroke Imaging Research Roadmap II. Stroke 2013;44:2628–39
    FREE Full Text
  3. 3.↵
    1. Wintermark M,
    2. Sanelli PC,
    3. Albers GW, et al
    . Imaging recommendations for acute stroke and transient ischemic attack patients: a joint statement by the American Society of Neuroradiology, the American College of Radiology, and the Society of NeuroInterventional Surgery. AJNR Am J Neuroradiol 2013;34:E117–27
    Abstract/FREE Full Text
  4. 4.↵
    1. Vahedi K,
    2. Vicaut E,
    3. Mateo J, et al
    . Sequential-design, multicenter, randomized, controlled trial of early decompressive craniectomy in malignant middle cerebral artery infarction (DECIMAL Trial). Stroke 2007;38:2506–17
    Abstract/FREE Full Text
  5. 5.↵
    1. Parsons M,
    2. Spratt N,
    3. Bivard A, et al
    . A randomized trial of tenecteplase versus alteplase for acute ischemic stroke. N Engl J Med 2012;366:1099–107
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Parsons MW,
    2. Christensen S,
    3. McElduff P, et al
    . Pretreatment diffusion- and perfusion-MR lesion volumes have a crucial influence on clinical response to stroke thrombolysis. J Cereb Blood Flow Metab 2010;30:1214–25
    CrossRefPubMed
  7. 7.↵
    1. Nagakane Y,
    2. Christensen S,
    3. Brekenfeld C, et al
    . EPITHET: positive result after reanalysis using baseline diffusion-weighted imaging/perfusion-weighted imaging co-registration. Stroke 2011;42:59–64
    Abstract/FREE Full Text
  8. 8.↵
    1. Barber PA,
    2. Demchuk AM,
    3. Zhang J, et al
    . Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy: ASPECTS Study Group—Alberta Stroke Programme Early CT Score. Lancet 2000;355:1670–74
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Inoue M,
    2. Mlynash M,
    3. Christensen S, et al
    . Early diffusion-weighted imaging reversal after endovascular reperfusion is typically transient in patients imaged 3 to 6 hours after onset. Stroke 2014;45:1024–28
    Abstract/FREE Full Text
  10. 10.↵
    1. Neumann AB,
    2. Jonsdottir KY,
    3. Mouridsen K, et al
    . Interrater agreement for final infarct MRI lesion delineation. Stroke 2009;40:3768–71
    Abstract/FREE Full Text
  11. 11.↵
    1. González RG,
    2. Schaefer PW,
    3. Buonanno FS, et al
    . Diffusion-weighted MR imaging: diagnostic accuracy in patients imaged within 6 hours of stroke symptom onset. Radiology 1999;210:155–62
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. González RG
    . Low signal, high noise and large uncertainty make CT perfusion unsuitable for acute ischemic stroke patient selection for endovascular therapy. J Neurointerv Surg 2012;4:242–45
    FREE Full Text
  13. 13.↵
    1. Campbell BC,
    2. Tu HT,
    3. Christensen S, et al
    . Assessing response to stroke thrombolysis: validation of 24-hour multimodal magnetic resonance imaging. Arch Neurol 2012;69:46–50
    CrossRefPubMed
  14. 14.↵
    1. Ay H,
    2. Arsava EM,
    3. Vangel M, et al
    . Interexaminer difference in infarct volume measurements on MRI: a source of variance in stroke research. Stroke 2008;39:1171–76
    Abstract/FREE Full Text
  15. 15.↵
    1. Kidwell CS,
    2. Jahan R,
    3. Gornbein J, et al
    . A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med 2013;368:914–23
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Powers WJ
    . Intravenous thrombolysis of basilar artery thrombosis. Ann Neurol 2014;75:456–57
  17. 17.↵
    National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995;333:1581–87
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Patel SC,
    2. Levine SR,
    3. Tilley BC, et al
    . Lack of clinical significance of early ischemic changes on computed tomography in acute stroke. JAMA 2001;286:2830–38
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Lansberg MG,
    2. Straka M,
    3. Kemp S, et al
    . MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study. Lancet Neurol 2012;11:860–67
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Simonsen CZ,
    2. Sørensen LH,
    3. Karabegovic S, et al
    . MRI before intraarterial therapy in ischemic stroke: feasibility, impact, and safety. J Cereb Blood Flow Metab 2014;34:1076–81
    CrossRefPubMed
  21. 21.↵
    1. Wisco D,
    2. Uchino K,
    3. Saqqur M, et al
    . Addition of hyperacute MRI aids in patient selection, decreasing the use of endovascular stroke therapy. Stroke 2014;45:467–72
    Abstract/FREE Full Text
  22. 22.↵
    1. Yoo AJ,
    2. Verduzco LA,
    3. Schaefer PW, et al
    . MRI-based selection for intra-arterial stroke therapy: value of pretreatment diffusion-weighted imaging lesion volume in selecting patients with acute stroke who will benefit from early recanalization. Stroke 2009;40:2046–54
    Abstract/FREE Full Text
  23. 23.↵
    1. Broderick JP,
    2. Palesch YY,
    3. Demchuk AM, et al
    . Endovascular therapy after intravenous t-PA versus t-PA alone for stroke. N Engl J Med 2013;368:893–903
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Tzoulaki I,
    2. Siontis KC,
    3. Evangelou E, et al
    . Bias in associations of emerging biomarkers with cardiovascular disease. JAMA Intern Med 2013;173:664–71
    CrossRefPubMed
  25. 25.↵
    1. Rothwell PM
    . Treating individuals 2: subgroup analysis in randomised controlled trials: importance, indications, and interpretation. Lancet 2005;365:176–86
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Tomsick T
    . TIMI, TIBI, TICI: I came, I saw, I got confused. AJNR Am J Neuroradiol 2007;28:382–84
    FREE Full Text
  27. 27.↵
    European Society of Radiology. White paper on imaging biomarkers. Insights Imaging 2010;1:42–45
    CrossRefPubMed
  28. 28.↵
    1. Kessler LG,
    2. Barnhart HX,
    3. Buckler AJ, et al
    . The emerging science of quantitative imaging biomarkers terminology and definitions for scientific studies and regulatory submissions. Stat Methods Med Res 2015;24:9–26
    Abstract/FREE Full Text
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 36 (5)
American Journal of Neuroradiology
Vol. 36, Issue 5
1 May 2015
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Imaging Biomarkers in Acute Ischemic Stroke Trials: A Systematic Review
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Imaging Biomarkers in Acute Ischemic Stroke Trials: A Systematic Review
G.W.J. Harston, N. Rane, G. Shaya, S. Thandeswaran, M. Cellerini, F. Sheerin, J. Kennedy
American Journal of Neuroradiology May 2015, 36 (5) 839-843; DOI: 10.3174/ajnr.A4208

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Imaging Biomarkers in Acute Ischemic Stroke Trials: A Systematic Review
G.W.J. Harston, N. Rane, G. Shaya, S. Thandeswaran, M. Cellerini, F. Sheerin, J. Kennedy
American Journal of Neuroradiology May 2015, 36 (5) 839-843; DOI: 10.3174/ajnr.A4208
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Acknowledgments
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Quantifying Infarct Growth and Secondary Injury Volumes: Comparing Multimodal Image Registration Measures
  • Quantification of Serial Cerebral Blood Flow in Acute Stroke Using Arterial Spin Labeling
  • Imaging Biomarkers in Ischemic Stroke Clinical Trials: An Opportunity for Rigor
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline
  • Evidence Levels for Neuroradiology Articles: Low Agreement among Raters
  • Imaging Biomarkers in Ischemic Stroke Clinical Trials: An Opportunity for Rigor
Show more RESEARCH PERSPECTIVES

Similar Articles

Advertisement

News and Updates

  • Lucien Levy Best Research Article Award
  • Thanks to our 2022 Distinguished Reviewers
  • Press Releases

Resources

  • Evidence-Based Medicine Level Guide
  • How to Participate in a Tweet Chat
  • AJNR Podcast Archive
  • Ideas for Publicizing Your Research
  • Librarian Resources
  • Terms and Conditions

Opportunities

  • Share Your Art in Perspectives
  • Get Peer Review Credit from Publons
  • Moderate a Tweet Chat

American Society of Neuroradiology

  • Neurographics
  • ASNR Annual Meeting
  • Fellowship Portal
  • Position Statements

© 2023 by the American Society of Neuroradiology | Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire