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Research ArticleADULT BRAIN

Three-Territory DWI Acute Infarcts: Diagnostic Value in Cancer-Associated Hypercoagulation Stroke (Trousseau Syndrome)

P.F. Finelli and A. Nouh
American Journal of Neuroradiology November 2016, 37 (11) 2033-2036; DOI: https://doi.org/10.3174/ajnr.A4846
P.F. Finelli
aFrom the Department of Neurology, Hartford Hospital and University of Connecticut School of Medicine, Hartford, Connecticut.
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A. Nouh
aFrom the Department of Neurology, Hartford Hospital and University of Connecticut School of Medicine, Hartford, Connecticut.
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    Figure.

    DWI infarcts involving bilateral anterior and posterior circulation (3 territory) with TS in 9 study group patients.

Tables

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  • Etiologies of 3 territory diffusion-weighted lesions

    No.Clinical/MR Imaging, DWI, Enhancement Features
    Suspected etiology (n = 29)
        Trauma1History of trauma, imaging-associated sequelae of trauma, subarachnoid hemorrhage, shear pattern
        Demyelinating1Age, history of multiple sclerosis, periventricular/corpus callosum predilection
        Hypoxic-ischemic5Hypotension, deep nuclei and cortical ribbon involvement
        Metastasis3History of malignancy and/or ring or enhancing lesion
        Seizure1Seizures, deep nuclei and/or cortical ribbon enhancement
        HIV-related (n = 2)
            Toxoplasmosis1HIV, periventricular, ring, enhancing, target sign, rarely shows restricted diffusion
            Fungal abscess1HIV, ring, enhancing, numerous restricted-diffusion lesions
        Cerebral emboli (n = 10)
            Endocarditis4Fever, leukocytosis, murmur, ring, enhancing
            Air1Followed esophagogastroduodenoscopy
            Fat1Followed long bone fracture
            Atrial fibrillation2No source other than atrial fibrillation found
            Aortic atheroma1Significant arch atheroma noted
            Aortic dissection1Patient had concomitant aortic dissection
        Postoperative (n = 6)
            Aneurysm coiling1Symptoms developed postoperatively
            Cardiac surgery4Symptoms developed postoperatively
            Aortic aneurysm repair1Symptoms developed postoperatively
    Not suspected (n = 10)
        Malignancy-related9Lung (n = 4), colon (n = 2), renal (n = 1), pancreas (n = 1), bladder (n = 1)
        Intravascular lymphoma1Proven by brain biopsy
    Indeterminate (n = 2)
        Incomplete history1Lost to follow-up
        Multiple etiologies1Possible fat emboli vs Trousseau syndrome
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American Journal of Neuroradiology: 37 (11)
American Journal of Neuroradiology
Vol. 37, Issue 11
1 Nov 2016
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Three-Territory DWI Acute Infarcts: Diagnostic Value in Cancer-Associated Hypercoagulation Stroke (Trousseau Syndrome)
P.F. Finelli, A. Nouh
American Journal of Neuroradiology Nov 2016, 37 (11) 2033-2036; DOI: 10.3174/ajnr.A4846

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Three-Territory DWI Acute Infarcts: Diagnostic Value in Cancer-Associated Hypercoagulation Stroke (Trousseau Syndrome)
P.F. Finelli, A. Nouh
American Journal of Neuroradiology Nov 2016, 37 (11) 2033-2036; DOI: 10.3174/ajnr.A4846
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