Quantitative Susceptibility Mapping and R2* Measured Changes during White Matter Lesion Development in Multiple Sclerosis: Myelin Breakdown, Myelin Debris Degradation and Removal, and Iron Accumulation
Article Information
- Received October 5, 2015
- Accepted after revision February 18, 2016
- Published online September 9, 2016.
Article Versions
- Latest version (June 2, 2016 - 06:46).
- You are viewing the most recent version of this article.
Author Information
- Y. Zhanga,b,
- S.A. Gauthierc,
- A. Guptab,
- W. Chena,
- J. Comunaleb,
- G.C.-Y. Chiangb,
- D. Zhoub,
- G. Askind,
- W. Zhua,
- D. Pitte and
- Y. Wangb,f
- aFrom the Department of Radiology (Y.Z., W.C., W.Z.), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- bDepartments of Radiology (Y.Z., A.G., J.C., G.C.-Y.C., D.Z., Y.W.)
- cNeurology (S.A.G.)
- dHealthcare Policy and Research (G.A.), Weill Cornell Medical College, New York, New York
- eDepartment of Neurology (D.P.), School of Medicine, Yale University, New Haven, Connecticut
- fDepartment of Biomedical Engineering (Y.W.), Cornell University, Ithaca, New York.
- Please address correspondence to Yi Wang, PhD, Department of Radiology, Weill Cornell Medical College, 515 East 71th St, New York, NY 10021; e-mail: yiwang{at}med.cornell.edu
Authors' contributions: Acquisition of data, analysis and interpretation of data, writing (Y.Z.); conception and design, acquisition of data, clinical study, manuscript revision (S.A.G.); acquisition of data, interpretation of image data, manuscript revision (A.G., W.C., J.C., G.C.-Y.C.); conception and design, manuscript revision (D.Z.); statistical analysis of data, statistical analysis writing (G.A.); conception and design, manuscript revision, study supervision (W.Z.); study conception, manuscript revision (D.P.); study conception and design, critical revision of manuscript, study supervision (Y.W.).
Altmetrics
Cited By...
This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.
- Yi Wang, Pascal Spincemaille, Zhe Liu, Alexey Dimov, Kofi Deh, Jianqi Li, Yan Zhang, Yihao Yao, Kelly M. Gillen, Alan H. Wilman, Ajay Gupta, Apostolos John Tsiouris, Ilhami Kovanlikaya, Gloria Chia‐Yi Chiang, Jonathan W. Weinsaft, Lawrence Tanenbaum, Weiwei Chen, Wenzhen Zhu, Shixin Chang, Min Lou, Brian H. Kopell, Michael G. Kaplitt, David Devos, Toshinori Hirai, Xuemei Huang, Yukunori Korogi, Alexander Shtilbans, Geon‐Ho Jahng, Daniel Pelletier, Susan A. Gauthier, David Pitt, Ashley I. Bush, Gary M. Brittenham, Martin R. PrinceJournal of Magnetic Resonance Imaging 2017 46 4
- Ulrike W. Kaunzner, Susan A. GauthierTherapeutic Advances in Neurological Disorders 2017 10 6
- Sarah Eskreis‐Winkler, Yan Zhang, Jingwei Zhang, Zhe Liu, Alexey Dimov, Ajay Gupta, Yi WangNMR in Biomedicine 2017 30 4
- Kiarash Ghassaban, Saifeng Liu, Caihong Jiang, E. Mark HaackeNeuroImage 2019 187
- Julio Acosta-Cabronero, Carlos Milovic, Hendrik Mattern, Cristian Tejos, Oliver Speck, Martina F. CallaghanNeuroImage 2018 183
- Ferdinand Schweser, Ana Luiza Raffaini Duarte Martins, Jesper Hagemeier, Fuchun Lin, Jannis Hanspach, Bianca Weinstock-Guttman, Simon Hametner, Niels Bergsland, Michael G. Dwyer, Robert ZivadinovNeuroImage 2018 167
- IEEE Transactions on Biomedical Engineering 2017 64 11
- Nathanael J. Lee, Seung-Kwon Ha, Pascal Sati, Martina Absinta, Govind Nair, Nicholas J. Luciano, Emily C. Leibovitch, Cecil C. Yen, Tracey A. Rouault, Afonso C. Silva, Steven Jacobson, Daniel S. ReichJournal of Clinical Investigation 2019 129 10
- Petr Dusek, Tim Hofer, Jan Alexander, Per M. Roos, Jan O. AasethBiomolecules 2022 12 5
- Y. Yao, T.D. Nguyen, S. Pandya, Y. Zhang, S. Hurtado Rúa, I. Kovanlikaya, A. Kuceyeski, Z. Liu, Y. Wang, S.A. GauthierAmerican Journal of Neuroradiology 2018 39 2
- Alberto Calvi, Lukas Haider, Ferran Prados, Carmen Tur, Declan Chard, Frederik BarkhofMultiple Sclerosis Journal 2022 28 5
- Kelly M. Gillen, Mayyan Mubarak, Calvin Park, Gerald Ponath, Shun Zhang, Alexey Dimov, Maya Levine‐Ritterman, Steven Toro, Weiyuan Huang, Stephanie Amici, Ulrike W. Kaunzner, Susan A. Gauthier, Mireia Guerau‐de‐Arellano, Yi Wang, Thanh D. Nguyen, David PittAnnals of Clinical and Translational Neurology 2021 8 4
- Chaoyue Wang, Sean Foxley, Olaf Ansorge, Sarah Bangerter-Christensen, Mark Chiew, Anna Leonte, Ricarda AL Menke, Jeroen Mollink, Menuka Pallebage-Gamarallage, Martin R Turner, Karla L Miller, Benjamin C. TendlerNeuroImage 2020 222
- Kofi Deh, Gerald D. Ponath, Zaki Molvi, Gian‐Carlo T. Parel, Kelly M. Gillen, Shun Zhang, Thanh D. Nguyen, Pascal Spincemaille, Yinghua Ma, Ajay Gupta, Susan A. Gauthier, David Pitt, Yi WangJournal of Magnetic Resonance Imaging 2018 48 5
- Shun Yao, Yi Zhong, Yuhao Xu, Jiasheng Qin, Ningning Zhang, Xiaolan Zhu, Yuefeng LiFrontiers in Human Neuroscience 2017 11
- Fuhua Yan, Naying He, Huimin Lin, Ruokun LiJournal of Magnetic Resonance Imaging 2018 48 2
- Fang F. Yu, Florence L. Chiang, Nicholas Stephens, Susie Y. Huang, Berkin Bilgic, Bundhit Tantiwongkosi, Rebecca RomeroNeuroradiology 2019 61 1
- Jinhee Jang, Yoonho Nam, Yangsean Choi, Na-Young Shin, Jae Young An, Kook-Jin Ahn, Bum-soo Kim, Kwang-Soo Lee, Woojun KimJournal of Clinical Neurology 2020 16 4
- Alberto Calvi, Margareta A Clarke, Ferran Prados, Declan Chard, Olga Ciccarelli, Manel Alberich, Deborah Pareto, Marta Rodríguez Barranco, Jaume Sastre-Garriga, Carmen Tur, Alex Rovira, Frederik BarkhofMultiple Sclerosis Journal 2023 29 3
- Mylyne Tham, Josa M. Frischer, Stephen D. Weigand, Patrick D. Fitz‐Gibbon, Samuel M. Webb, Yong Guo, Reginald C. Adiele, Christopher A. Robinson, Wolfgang Brück, Hans Lassmann, Kendra L. Furber, M. Jake Pushie, Joseph E. Parisi, Claudia F. Lucchinetti, Bogdan F. PopescuAnnals of Neurology 2021 89 3
- Ahmed M. Elkady, Dana Cobzas, Hongfu Sun, Gregg Blevins, Alan H. WilmanJournal of Magnetic Resonance Imaging 2018 48 3
- Nelly Blindenbacher, Eveline Brunner, Susanna Asseyer, Michael Scheel, Nadja Siebert, Ludwig Rasche, Judith Bellmann-Strobl, Alexander Brandt, Klemens Ruprecht, Dominik Meier, Jens Wuerfel, Friedemann Paul, Tim SinneckerMultiple Sclerosis Journal - Experimental, Translational and Clinical 2020 6 1
- Nian Wang, Gary Cofer, Robert J Anderson, Yi Qi, Chunlei Liu, G Allan JohnsonPhysics in Medicine & Biology 2018 63 24
- Eileanoir B. Johnson, Christopher S. Parker, Rachael I. Scahill, Sarah Gregory, Marina Papoutsi, Paul Zeun, Katherine Osborne-Crowley, Jessica Lowe, Akshay Nair, Carlos Estevez-Fraga, Kate Fayer, Geraint Rees, Hui Zhang, Sarah J. TabriziEBioMedicine 2021 65
- Pascal Spincemaille, Zhe Liu, Shun Zhang, Ilhami Kovanlikaya, Matteo Ippoliti, Marcus Makowski, Richard Watts, Ludovic de Rochefort, Vijay Venkatraman, Patricia Desmond, Mathieu D. Santin, Stéphane Lehéricy, Brian H. Kopell, Patrice Péran, Yi WangJournal of Neuroimaging 2019 29 6
- M. Castellaro, R. Magliozzi, A. Palombit, M. Pitteri, E. Silvestri, V. Camera, S. Montemezzi, F.B. Pizzini, A. Bertoldo, R. Reynolds, S. Monaco, M. CalabreseAmerican Journal of Neuroradiology 2017 38 6
- Riikka Immonen, Neil G. Harris, David Wright, Leigh Johnston, Eppu Manninen, Gregory Smith, Afshin Paydar, Craig Branch, Olli GrohnNeurobiology of Disease 2019 123
- Arnold M. Evia, Aikaterini Kotrotsou, Ashish A. Tamhane, Robert J. Dawe, Alifiya Kapasi, Sue E. Leurgans, Julie A. Schneider, David A. Bennett, Konstantinos Arfanakis, James R. ConnorPLOS ONE 2017 12 12
- Giuseppe Pontillo, Sirio Cocozza, Roberta Lanzillo, Pasquale Borrelli, Anna De Rosa, Vincenzo Brescia Morra, Enrico Tedeschi, Giuseppe PalmaFrontiers in Neurology 2017 8
- Shun Zhang, Zhe Liu, Thanh D. Nguyen, Yihao Yao, Kelly M. Gillen, Pascal Spincemaille, Ilhami Kovanlikaya, Ajay Gupta, Yi WangMagnetic Resonance Imaging 2019 60
- Seulki Yoo, Joo-won Kim, John F. Schenck, Seung-Kyun LeeScientific Reports 2020 10 1
- Ewart Mark Haacke, Evanthia Bernitsas, Karthik Subramanian, David Utriainen, Vinay Kumar Palutla, Kiran Yerramsetty, Prashanth Kumar, Sean K. Sethi, Yongsheng Chen, Zahid Latif, Pavan Jella, Sara Gharabaghi, Ying Wang, Xiaomeng Zhang, Robert A. Comley, John Beaver, Yanping LuoDiagnostics 2021 12 1
- Zhuoxin Guo, Liu Long, Wei Qiu, Tingting Lu, Lina Zhang, Yaqing Shu, Ke Zhang, Ling Fang, Shaoqiong ChenFrontiers in Neurology 2021 12
- Woojun Kim, Hyeong-Geol Shin, Hyebin Lee, Dohoon Park, Junghwa Kang, Yoonho Nam, Jongho Lee, Jinhee JangRadiology 2023 307 1
- Selvadasan Vinayagamani, Sekar Sabarish, Sruthi S. Nair, Vaibhav Tandon, Chandrasekharan Kesavadas, Bejoy ThomasNeuroradiology 2021 63 7
- Kaibao Sun, Jianfei Cui, Rong Xue, Tao Jiang, Bo Wang, Zihao Zhang, Yan Zhuo, Xiaohong Joe Zhou, Shuli Liang, Xinguang Yu, Lin ChenNMR in Biomedicine 2021 34 9
- M. Tranfa, G. Pontillo, M. Petracca, A. Brunetti, E. Tedeschi, G. Palma, S. CocozzaAmerican Journal of Neuroradiology 2022 43 12
- Kevin Yuqi Wang, Joshua Carlton, Danielle Guffey, George J. Hutton, Fanny E. MoronClinical Imaging 2020 59 1
- Fábio Seiji Otsuka, Maria Concepción Garcia Otaduy, Otaciro Rangel Nascimento, Carlos Ernesto Garrido SalmonBrazilian Journal of Physics 2022 52 3
- Rapid simultaneous acquisition of macromolecular tissue volume, susceptibility, and relaxometry mapsFang Frank Yu, Susie Yi Huang, Ashwin Kumar, Thomas Witzel, Congyu Liao, Tanguy Duval, Julien Cohen‐Adad, Berkin BilgicMagnetic Resonance in Medicine 2022 87 2
- G. Caruana, C. Auger, L.M. Pessini, W. Calderon, A. de Barros, A. Salerno, J. Sastre-Garriga, X. Montalban, À. RoviraAmerican Journal of Neuroradiology 2022 43 4
- Huiting Liao, Zimeng Cai, Haiqi Ye, QianLan Chen, Yan Zhang, Mehran Shaghaghi, Sarah E. Lutz, Weiwei Chen, Kejia CaiFrontiers in Neuroscience 2023 16
- Xuan Vinh To, Viktor Vegh, Naana Owusu-Amoah, Paul Cumming, Fatima A. NasrallahExperimental Neurology 2023 365
- Zhuowei Shi, Yang Pan, Zichun Yan, Shuang Ding, Hai Hu, Yiqiu Wei, Dan Luo, Yuhui Xu, Qiyuan Zhu, Yongmei LiMultiple Sclerosis and Related Disorders 2023 71
- Ashley Parr, Bart Larsen, Finnegan Calabro, Brenden Tervo-Clemmens, Beatriz Luna2023 193
- Ziyan Zhu, Nashwan Naji, Javad Hamidi Esfahani, Jeff Snyder, Peter Seres, Derek J. Emery, Michelle Noga, Gregg Blevins, Penelope Smyth, Alan H. WilmanJournal of Magnetic Resonance Imaging 2024
- Ibrahim Khormi, Oun Al-iedani, Abdulaziz Alshehri, Saadallah Ramadan, Jeannette Lechner-ScottJournal of the Neurological Sciences 2023 455
- M. S. Matrosova, V. V. Bryukhov, E. V. Popova, G. N. Belskaya, M. V. KrotenkovaNeurology, Neuropsychiatry, Psychosomatics 2023 15 6
- M. S. Matrosova, V. V. Bryukhov, E. V. Popova, G. N. Belskaya, M. V. KrotenkovaMedical Visualization 2023 27 2
- Mingjia Hou, Yan Zhang, Ajay Gupta, Susan A. Gauthier, Yi Wang, Weiwei ChenRadiology Science 2023 2 1
- Cui Ci Voon, Tun Wiltgen, Benedikt Wiestler, Sarah Schlaeger, Mark MühlauNeuroImage: Clinical 2024 42
- Chenyang Gao, Lei Su, Hongfang Li, Tian Song, Yaou Liu, Yunyun Duan, Fu-Dong ShiMultiple Sclerosis and Related Disorders 2024 82
- Ming‐Long Wu, Chun‐Kun Wang, Po‐Yu Lin, Tzu‐Cheng ChaoMedical Physics 2020 47 11
- Dan Luo, Yuling Peng, Qiyuan Zhu, Qiao Zheng, Qi Luo, Yongliang Han, Xiaoya Chen, Yongmei LiEuropean Radiology 2023 34 3
In this issue
Jump to section
Related Articles
- No related articles found.
Cited By...
- Quantitative MRI in Multiple Sclerosis: From Theory to Application
- SWI as an Alternative to Contrast-Enhanced Imaging to Detect Acute MS Lesions
- Rapid simultaneous acquisition of macromolecular tissue volume, susceptibility, and relaxometry maps
- Methods for quantitative susceptibility and R2* mapping in whole post-mortem brains at 7T
- Quantitative Susceptibility Mapping of Time-Dependent Susceptibility Changes in Multiple Sclerosis Lesions
- Combining Quantitative Susceptibility Mapping with Automatic Zero Reference (QSM0) and Myelin Water Fraction Imaging to Quantify Iron-Related Myelin Damage in Chronic Active MS Lesions
- Heterogeneity of Cortical Lesion Susceptibility Mapping in Multiple Sclerosis
This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.
- Yi Wang, Pascal Spincemaille, Zhe Liu, Alexey Dimov, Kofi Deh, Jianqi Li, Yan Zhang, Yihao Yao, Kelly M. Gillen, Alan H. Wilman, Ajay Gupta, Apostolos John Tsiouris, Ilhami Kovanlikaya, Gloria Chia‐Yi Chiang, Jonathan W. Weinsaft, Lawrence Tanenbaum, Weiwei Chen, Wenzhen Zhu, Shixin Chang, Min Lou, Brian H. Kopell, Michael G. Kaplitt, David Devos, Toshinori Hirai, Xuemei Huang, Yukunori Korogi, Alexander Shtilbans, Geon‐Ho Jahng, Daniel Pelletier, Susan A. Gauthier, David Pitt, Ashley I. Bush, Gary M. Brittenham, Martin R. PrinceJournal of Magnetic Resonance Imaging 2017 46 4
- Ulrike W. Kaunzner, Susan A. GauthierTherapeutic Advances in Neurological Disorders 2017 10 6
- Sarah Eskreis‐Winkler, Yan Zhang, Jingwei Zhang, Zhe Liu, Alexey Dimov, Ajay Gupta, Yi WangNMR in Biomedicine 2017 30 4
- Kiarash Ghassaban, Saifeng Liu, Caihong Jiang, E. Mark HaackeNeuroImage 2019 187
- Julio Acosta-Cabronero, Carlos Milovic, Hendrik Mattern, Cristian Tejos, Oliver Speck, Martina F. CallaghanNeuroImage 2018 183
- Ferdinand Schweser, Ana Luiza Raffaini Duarte Martins, Jesper Hagemeier, Fuchun Lin, Jannis Hanspach, Bianca Weinstock-Guttman, Simon Hametner, Niels Bergsland, Michael G. Dwyer, Robert ZivadinovNeuroImage 2018 167
- IEEE Transactions on Biomedical Engineering 2017 64 11
- Nathanael J. Lee, Seung-Kwon Ha, Pascal Sati, Martina Absinta, Govind Nair, Nicholas J. Luciano, Emily C. Leibovitch, Cecil C. Yen, Tracey A. Rouault, Afonso C. Silva, Steven Jacobson, Daniel S. ReichJournal of Clinical Investigation 2019 129 10
- Petr Dusek, Tim Hofer, Jan Alexander, Per M. Roos, Jan O. AasethBiomolecules 2022 12 5
- Y. Yao, T.D. Nguyen, S. Pandya, Y. Zhang, S. Hurtado Rúa, I. Kovanlikaya, A. Kuceyeski, Z. Liu, Y. Wang, S.A. GauthierAmerican Journal of Neuroradiology 2018 39 2