Assessment of Iron Deposition in the Brain in Frontotemporal Dementia and Its Correlation with Behavioral Traits

References

1. 1.↵
   2. Neary D,
   3. Snowden JS,
   4. Gustafson L, et al

   . Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 1998;51:1546–54 doi:10.1212/WNL.51.6.1546 pmid:9855500

   Abstract/FREE Full Text
2. 2.↵
   2. Perry RJ,
   3. Graham A,
   4. Williams G, et al

   . Patterns of frontal lobe atrophy in frontotemporal dementia: a volumetric MRI study. Dement Geriatr Cogn Disord 2006;22:278–87 doi:10.1159/000095128 pmid:16914925

   CrossRefPubMedWeb of Science
3. 3.↵
   2. Zhou B,
   3. Li S,
   4. Huijin H, et al

   . The evaluation of iron content in Alzheimer's disease by magnetic resonance imaging: phase and R2* methods. Adv Alzheimer Dis 2013;2:51–59 doi:10.4236/aad.2013.22007

   CrossRef
4. 4.↵
   2. Wu SF,
   3. Zhu ZF,
   4. Kong Y, et al

   . Assessment of cerebral iron content in patients with Parkinson's disease by the susceptibility-weighted MRI. Eur Rev Med Pharmacol Sci 2014;18:2605–08 pmid:25317792

   PubMed
5. 5.↵
   2. Ropele S,
   3. de Graaf W,
   4. Khalil M, et al

   . MRI assessment of iron deposition in multiple sclerosis. J Magn Reson Imaging 2011;34:13–21 doi:10.1002/jmri.22590 pmid:21698703

   CrossRefPubMed
6. 6.↵
   2. Adachi Y,
   3. Sato N,
   4. Saito Y, et al

   . Usefulness of SWI for the detection of iron in the motor cortex in amyotrophic lateral sclerosis. J Neuroimaging 2015;25:443–51 doi:10.1111/jon.12127 pmid:24888543

   CrossRefPubMed
7. 7.↵
   2. Kwan JY,
   3. Jeong SY,
   4. Van Gelderen P, et al

   . Iron accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: correlating 7 Tesla MRI and pathology. PLoS One 2012;7:e35241 doi:10.1371/journal.pone.0035241 pmid:22529995

   CrossRefPubMed
8. 8.↵
   2. Batista-Nascimento L,
   3. Pimentel C,
   4. Menezes RA, et al

   . Iron and neurodegeneration: from cellular homeostasis to disease. Oxid Med Cell Longev 2012;2012:128647 doi:10.1155/2012/12864 pmid:22701145

   CrossRefPubMed
9. 9.↵
   2. Sheelakumari R,
   3. Madhusoodanan M,
   4. Radhakrishnan A, et al

   . A potential biomarker in amyotrophic lateral sclerosis: can assessment of brain iron deposition with SWI and corticospinal tract degeneration with DTI help? AJNR Am J Neuroradiol 2016;37:252–58 doi:10.3174/ajnr.A4524 pmid:26494694

   Abstract/FREE Full Text
10. 10.↵
    2. Wang D,
    3. Zhu D,
    4. Wei XE, et al

    . Using susceptibility-weighted images to quantify iron deposition differences in amnestic mild cognitive impairment and Alzheimer's disease. Neurol India 2013;61:26–34 doi:10.4103/0028-3886.107924 pmid:23466836

    CrossRefPubMed
11. 11.↵
    2. Raven EP,
    3. Lu PH,
    4. Tishler TA, et al

    . Increased iron levels and decreased tissue integrity in hippocampus of Alzheimer's disease detected in vivo with magnetic resonance imaging. J Alzheimers Dis 2013;37:127–36 doi:10.3233/JAD-130209 pmid:23792695

    CrossRefPubMed
12. 12.↵
    2. Santillo AF,
    3. Skoglund L,
    4. Lindau M, et al

    . Frontotemporal dementia-amyotrophic lateral sclerosis complex is simulated by neurodegeneration with brain iron accumulation. Alzheimer Dis Assoc Disord 2009;23:298–300 doi:10.1097/WAD.0b013e3181a2b76b pmid:19568152

    CrossRefPubMed
13. 13.↵
    2. Ehmann WD,
    3. Alauddin M,
    4. Hossain TI, et al

    . Brain trace elements in Pick's disease. Ann Neurol 1984;15:102–04 doi:10.1002/ana.410150119 pmid:6712183

    CrossRefPubMedWeb of Science
14. 14.↵
    2. De Reuck JL,
    3. Deramecourt V,
    4. Auger F, et al

    . Iron deposits in post-mortem brains of patients with neurodegenerative and cerebrovascular diseases: a semi-quantitative 7.0 T magnetic resonance imaging study. Eur J Neurol 2014;21:1026–31 doi:10.1111/ene.12432 pmid:24698410

    CrossRefPubMed
15. 15.
    2. Mackenzie IA,
    3. Neumann M,
    4. Bigio EH, et al

    . Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol (Berl) 2010;119:1–4 doi:10.1007/s00401-009-0612-2 pmid:19924424

    CrossRefPubMedWeb of Science
16. 16.
    2. Neumann M,
    3. Rademakers R,
    4. Roeber S, et al

    . A new subtype of frontotemporal lobar degeneration with FUS pathology. Brain J Neurol 2009;132(pt 11):2922–31 doi:10.1093/brain/awp214 pmid:19674978

    CrossRefPubMedWeb of Science
17. 17.↵
    2. Garibotto V,
    3. Borroni B,
    4. Agosti C, et al

    . Subcortical and deep cortical atrophy in frontotemporal lobar degeneration. Neurobiol Aging 2011;32:875–84 doi:10.1016/j.neurobiolaging.2009.05.004 pmid:19501427

    CrossRefPubMedWeb of Science
18. 18.↵
    2. Feder JN,
    3. Penny DM,
    4. Irrinki A, et al

    . The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci U S A 1998;95:1472–7 doi:10.1073/pnas.95.4.1472 pmid:9465039

    Abstract/FREE Full Text
19. 19.↵
    2. Gazzina S,
    3. Premi E,
    4. Zanella I, et al

    . Iron in frontotemporal lobar degeneration: a new subcortical pathological pathway? Neurodegener Dis 2016;16:172–78 doi:10.1159/000440843 pmid:26613252

    CrossRefPubMed
20. 20.↵
    2. Haacke EM,
    3. Ayaz M,
    4. Khan A, et al

    . Establishing a baseline phase behavior in magnetic resonance imaging to determine normal vs. abnormal iron content in the brain. J Magn Reson Imaging 2007;26:256–64 doi:10.1002/jmri.22987 pmid:17654738

    CrossRefPubMedWeb of Science
21. 21.↵
    2. Haacke EM,
    3. Makki M,
    4. Ge Y, et al

    . Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging. J Magn Reson Imaging 2009;29:537–44 doi:10.1002/jmri.21676 pmid:19243035

    CrossRefPubMed
22. 22.↵
    2. Thomas B,
    3. Somasundaram S,
    4. Thamburaj K, et al

    . Clinical applications of susceptibility weighted MR imaging of the brain: a pictorial review. Neuroradiology 2008;50:105–16 pmid:17929005

    CrossRefPubMedWeb of Science
23. 23.↵
    2. Rascovsky K,
    3. Hodges JR,
    4. Knopman D, et al

    . Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 2011;134:2456–77 doi:10.1093/brain/awr179 pmid:21810890

    CrossRefPubMedWeb of Science
24. 24.↵
    2. Mesulam MM

    . Primary progressive aphasia. Ann Neurol 2001;49:425–32 pmid:11310619

    CrossRefPubMedWeb of Science
25. 25.↵
    2. Gorno-Tempini ML,
    3. Hillis AE,
    4. Weintraub S, et al

    . Classification of primary progressive aphasia and its variants. Neurology 2011;76:1006–14 doi:10.1212/WNL.0b013e31821103e6 pmid:21325651

    Abstract/FREE Full Text
26. 26.↵
    2. Mathuranath PS,
    3. Cherian JP,
    4. Mathew R, et al

    . Mini mental state examination and the Addenbrooke's cognitive examination: effect of education and norms for a multicultural population. Neurol India 2007;55:106–10 doi:10.4103/0028-3886.32779 pmid:17558112

    CrossRefPubMedWeb of Science
27. 27.↵
    2. Bertoux M,
    3. O'Callaghan C,
    4. Flanagan E, et al

    . Fronto-striatal atrophy in behavioral variant frontotemporal dementia and Alzheimer's disease. Front Neurol 2015;6:147 doi:10.3389/fneur.2015.00147 pmid:26191038

    CrossRefPubMed
28. 28.↵
    2. Nguyen T,
    3. Bertoux M,
    4. O'Callaghan C, et al

    . Grey and white matter brain network changes in frontotemporal dementia subtypes. Transl Neurosci 2013;4:410–18
29. 29.↵
    2. Whitwell JL,
    3. Przybelski SA,
    4. Weigand SD, et al

    . Distinct anatomical subtypes of the behavioural variant of frontotemporal dementia: a cluster analysis study. Brain 2009;132(pt 11):2932–46 doi:10.1093/brain/awp232 pmid:19762452

    CrossRefPubMedWeb of Science
30. 30.↵
    2. Seelaar H,
    3. Rohrer JD,
    4. Pijnenburg YAL, et al

    . Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review. J Neurol Neurosurg Psychiatry 2011;82:476–86 doi:10.1136/jnnp.2010.212225 pmid:20971753

    Abstract/FREE Full Text
31. 31.↵
    2. Duval C,
    3. Bejanin A,
    4. Piolino P, et al

    . Theory of mind impairments in patients with semantic dementia. Brain 2012;135(pt 1):228–41 doi:10.1093/brain/awr30 pmid:22232593

    CrossRefPubMedWeb of Science
32. 32.↵
    2. Haacke EM,
    3. Cheng NY,
    4. House MJ, et al

    . Imaging iron stores in the brain using magnetic resonance imaging. Magn Reson Imaging 2005;23:1–25 doi:10.1016/j.mri.2004.10.001 pmid:15733784

    CrossRefPubMedWeb of Science
33. 33.↵
    2. Rouault TA,
    3. Cooperman S

    . Brain iron metabolism. Semin Pediatr Neurol 2006;13:142–48 doi:10.1016/j.spen.2006.08.002 pmid:17101452

    CrossRefPubMed
34. 34.↵
    2. De Reuck J,
    3. Deramecourt V,
    4. Cordonnier C, et al

    . Detection of microbleeds in post-mortem brains of patients with frontotemporal lobar degeneration: a 7.0-Tesla magnetic resonance imaging study with neuropathological correlates. Eur J Neurol 2012;19:1355–60 doi:10.1111/j.1468-1331.2012.03776.x pmid:22642502

    CrossRefPubMed
35. 35.↵
    2. Ward RJ,
    3. Crichton RR,
    4. Taylor DL, et al

    . Iron and the immune system. J Neural Transm (Vienna) 2011;118:315–28 doi:10.1007/s00702-010-0479-3 pmid:20878427

    CrossRefPubMed
36. 36.↵
    2. Connor JR,
    3. Boeshore KL,
    4. Benkovic SA, et al

    . Isoforms of ferritin have a specific cellular distribution in the brain. J Neurosci Res 1994;37:461–65 doi:10.1002/jnr.490370405 pmid:8021970

    CrossRefPubMedWeb of Science
37. 37.↵
    2. Ridolfi E,
    3. Barone C,
    4. Scarpini E, et al

    . The role of the innate immune system in Alzheimer's disease and frontotemporal lobar degeneration: an eye on microglia. Clin Dev Immunol 2013;2013:939786 doi:10.1155/2013/939786 pmid:23970926

    CrossRefPubMed
38. 38.↵
    2. Boccardi M,
    3. Sabattoli F,
    4. Laakso MP, et al

    . Frontotemporal dementia as a neural system disease. Neurobiol Aging 2005;26:37–44 doi:10.1016/j.neurobiolaging.2004.02.019 pmid:15585344

    CrossRefPubMedWeb of Science
39. 39.↵
    2. Borroni B,
    3. Brambati SM,
    4. Agosti C, et al

    . Evidence of white matter changes on diffusion tensor imaging in frontotemporal dementia. Arch Neurol 2007;64:246–51 doi:10.1001/archneur.64.2.246 pmid:17296841

    CrossRefPubMedWeb of Science
40. 40.↵
    2. Agosta F,
    3. Scola E,
    4. Canu E, et al

    . White matter damage in frontotemporal lobar degeneration spectrum. Cereb Cortex 2012;22:2705–14 doi:10.1093/cercor/bhr288 pmid:21988828

    CrossRefPubMedWeb of Science
41. 41.↵
    2. Josephs KA

    . Frontotemporal dementia and related disorders: deciphering the enigma. Ann Neurol 2008;64:4–14 doi:10.1002/ana.21426 pmid:18668533

    CrossRefPubMedWeb of Science
42. 42.↵
    2. Leh SE,
    3. Ptito A,
    4. Chakravarty MM, et al

    . Fronto-striatal connections in the human brain: a probabilistic diffusion tractography study. Neurosci Lett 2007;419:113–18 doi:10.1016/j.neulet.2007.04.049 pmid:17485168

    CrossRefPubMedWeb of Science
43. 43.↵
    2. Nioche C,
    3. Cabanis EA,
    4. Habas C

    . Functional connectivity of the human red nucleus in the brain resting state at 3T. AJNR Am J Neuroradiol 2009;30:396–403 pmid:19022864

    Abstract/FREE Full Text
44. 44.↵
    2. Eslinger PJ,
    3. Moore P,
    4. Antani S, et al

    . Apathy in frontotemporal dementia: behavioral and neuroimaging correlates. Behav Neurol 2012;25:127–36 doi:10.1155/2012/286427 pmid:22425723

    CrossRefPubMed
45. 45.↵
    2. Halabi C,
    3. Halabi A,
    4. Dean DL, et al

    . Patterns of striatal degeneration in frontotemporal dementia. Alzheimer Dis Assoc Disord 2013;27:74–83 doi:10.1097/WAD.0b013e31824a7df4 pmid:22367382

    CrossRefPubMed
46. 46.↵
    2. Macfarlane MD,
    3. Jakabek D,
    4. Walterfang M, et al

    . Striatal atrophy in the behavioural variant of frontotemporal dementia: correlation with diagnosis, negative symptoms and disease severity. PLoS One 2015;10:e0129692 doi:10.1371/journal.pone.0129692 pmid:26075893

    CrossRefPubMed