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Research ArticleAdult Brain

Do All Patients with Multiple Sclerosis Benefit from the Use of Contrast on Serial Follow-Up MR Imaging? A Retrospective Analysis

R.R. Mattay, K. Davtyan, M. Bilello and A.C. Mamourian
American Journal of Neuroradiology November 2018, 39 (11) 2001-2006; DOI: https://doi.org/10.3174/ajnr.A5828
R.R. Mattay
aFrom the Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
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K. Davtyan
aFrom the Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
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M. Bilello
aFrom the Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
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  • ORCID record for M. Bilello
A.C. Mamourian
aFrom the Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
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    Fig 1.

    Prior FLAIR MR imaging in the upper left-hand corner, current FLAIR MR imaging in the lower left-hand corner, and the coregistered composite image on the right displaying new lesions in red, while lesions that regressed are green.

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    Fig 2.

    Left: Contrast-enhanced T1 MR imaging shows enhancement of a pre-existing lesion in the right centrum semiovale (arrow). Middle: The composite image from the coregistering software shows no growth of this corresponding lesion on FLAIR between the prior and current study (arrow). Additionally, 1 lesion had slightly regressed in the right posterior corona radiata (green on the composite image). Right: The composite image using the coregistering software at a more inferior level shows evidence of a new lesion in the splenium of the corpus callosum (arrow and red on composite image on the right).

Tables

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  • Patients on IMT at the time of their most recent scan

    Type of IMTNo. of Patients
    Fingolimod11
    Glatiramer acetate36
    Interferon β-1a23
    Ocrelizumab1
    Dimethyl fumarate1
    Teriflunomide9
    Natalizumab1
    • Note:—IMT indicates immune-modulating therapy.

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American Journal of Neuroradiology: 39 (11)
American Journal of Neuroradiology
Vol. 39, Issue 11
1 Nov 2018
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Do All Patients with Multiple Sclerosis Benefit from the Use of Contrast on Serial Follow-Up MR Imaging? A Retrospective Analysis
R.R. Mattay, K. Davtyan, M. Bilello, A.C. Mamourian
American Journal of Neuroradiology Nov 2018, 39 (11) 2001-2006; DOI: 10.3174/ajnr.A5828

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Do All Patients with Multiple Sclerosis Benefit from the Use of Contrast on Serial Follow-Up MR Imaging? A Retrospective Analysis
R.R. Mattay, K. Davtyan, M. Bilello, A.C. Mamourian
American Journal of Neuroradiology Nov 2018, 39 (11) 2001-2006; DOI: 10.3174/ajnr.A5828
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  • Comparison of Unenhanced and Gadolinium-Enhanced Imaging in Multiple Sclerosis: Is Contrast Needed for Routine Follow-Up MRI?
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