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Research ArticleInterventional

Investigation of a New Version of the Liquid Embolic Agent PHIL with Extra-Low-Viscosity in an Endovascular Embolization Model

D.F. Vollherbst, R. Otto, M. Hantz, C. Ulfert, H.U. Kauczor, M. Bendszus, C.M. Sommer and M.A. Möhlenbruch
American Journal of Neuroradiology September 2018, 39 (9) 1696-1702; DOI: https://doi.org/10.3174/ajnr.A5750
D.F. Vollherbst
aFrom the Department of Neuroradiology (D.F.V., R.O., M.H., C.U., M.B., M.A.M.)
bClinic for Diagnostic and Interventional Radiology (D.F.V., H.U.K., C.M.S.), Heidelberg University Hospital, Heidelberg, Germany
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R. Otto
aFrom the Department of Neuroradiology (D.F.V., R.O., M.H., C.U., M.B., M.A.M.)
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M. Hantz
aFrom the Department of Neuroradiology (D.F.V., R.O., M.H., C.U., M.B., M.A.M.)
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C. Ulfert
aFrom the Department of Neuroradiology (D.F.V., R.O., M.H., C.U., M.B., M.A.M.)
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H.U. Kauczor
bClinic for Diagnostic and Interventional Radiology (D.F.V., H.U.K., C.M.S.), Heidelberg University Hospital, Heidelberg, Germany
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M. Bendszus
aFrom the Department of Neuroradiology (D.F.V., R.O., M.H., C.U., M.B., M.A.M.)
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C.M. Sommer
bClinic for Diagnostic and Interventional Radiology (D.F.V., H.U.K., C.M.S.), Heidelberg University Hospital, Heidelberg, Germany
cClinic for Diagnostic and Interventional Radiology (C.M.S.), Klinikum Stuttgart, Stuttgart, Germany.
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M.A. Möhlenbruch
aFrom the Department of Neuroradiology (D.F.V., R.O., M.H., C.U., M.B., M.A.M.)
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  • Fig 1.
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    Fig 1.

    Representative embolization procedure with PHIL 25% LV. A, Before the embolization procedure, a diagnostic angiography is performed through a guiding catheter. The RM is delineated in the diagnostic angiography image with complete filling of the RM. B, X-ray after the first injection. After the first injection, most of the RM is already embolized. The injection is stopped because of embolization distal to the RM (arrow). C, X-ray after the second injection. The second injection leads to slight additional filling of the lateral parts of the RM (black arrow). The injection is stopped because of reflux (arrowhead). Retrospectively, this is the injection with which the maximal embolization extent was reached. Accordingly, the reflux distance is measured in this image (double arrow). X-rays after the fifth (D) and eighth (E) injections. No more filling of the RM is achieved with the following injections, which were all stopped because of reflux (arrowheads). After the eighth injection, the procedure is terminated because of reflux of the LEA into the APA (arrow). F, After termination of the procedure, the catheters are removed and the embolized portion of the RM is delineated. The area of the completely filled RM (A) and the area of the embolized RM (F) are related, resulting in the embolization extent.

  • Fig 2.
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    Fig 2.

    Visibility of the embolic agents. X-rays after the first injection shown for PHIL 25% LV (A), Squid 12 (B), and standard PHIL 25% (C). Note the adequate visibility of all 3 embolic agents.

  • Fig 3.
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    Fig 3.

    Illustration of embolization extent and reflux distance. A, The embolization extent tended to be higher for PHIL 25% LV, however, without reaching statistical significance. B, The reflux distance was significantly lower for the 2 extra-low-viscosity LEAs PHIL 25% LV and Squid 12 compared with standard PHIL 25%.

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    Fig 4.

    Distribution of the LEA in HR-DVT. The distribution of the LEA in HR-DVT is shown for 2 representative cases. A–E, PHIL 25% LV. F–J, Standard PHIL 25%. A and F, Postinterventional x-rays. B and G, Volume-rendering of the HR-DVT dataset. C and H, Coronal HR-DVT images. D, E, I, and J, Axial HR-DVT images of the middle (E and J) and the distal (D and I) parts of the RM (lines in C and H indicate the position of the axial planes). Note the perceptibility of single blood vessels of the RM in the high-resolution HR-DVT images. Well-circumscribed filling defects were identified in the axial HR-DVT images, which were particularly detected in the distal, only partially embolized parts of the RM (white arrows). The same filling defects were also seen in the 2D x-rays (black arrows).

Tables

  • Figures
  • Summary of the resultsa

    PHIL 25% LVSquid 12Standard PHIL 25%P Value
    Total procedure time (s)395 (310–528)436 (430–501)328 (239–479).386b
    Required volume of embolic agent (mL)0.7 (0.7–0.9)0.8 (0.7–0.9)0.7 (0.6–0.7).121b
    Visibility3 (3–3)3 (3–3)3 (3–3)NA
    Forward flow control5 (5–5)5 (5–5)5 (5–5).335b
    Embolization extent (%)87.7 (68.0–100)64.6 (52.2–73.0)60.4 (27.0–75.9).146b
    Reflux distance (mm)8 (6–8)6 (5–10)17 (14–21).011b
    >.999c
    .049d
    .017e
    Events of embolization distal to the RM per procedure (No.)0 (0–1)0 (0–0)0 (0–0).527b
    • Note:—NA indicates that the P value was not available because all values are identical.

    • ↵a Data are presented as median (lower quartile–upper quartile).

    • ↵b Kruskal-Wallis test.

    • ↵c Post hoc Dunn test, PHIL 25% LV vs Squid 12.

    • ↵d Post hoc Dunn test, PHIL 25% LV vs standard PHIL 25%.

    • ↵e Post hoc Dunn test, Squid 12 vs. standard PHIL 25%.

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American Journal of Neuroradiology: 39 (9)
American Journal of Neuroradiology
Vol. 39, Issue 9
1 Sep 2018
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Investigation of a New Version of the Liquid Embolic Agent PHIL with Extra-Low-Viscosity in an Endovascular Embolization Model
D.F. Vollherbst, R. Otto, M. Hantz, C. Ulfert, H.U. Kauczor, M. Bendszus, C.M. Sommer, M.A. Möhlenbruch
American Journal of Neuroradiology Sep 2018, 39 (9) 1696-1702; DOI: 10.3174/ajnr.A5750

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Investigation of a New Version of the Liquid Embolic Agent PHIL with Extra-Low-Viscosity in an Endovascular Embolization Model
D.F. Vollherbst, R. Otto, M. Hantz, C. Ulfert, H.U. Kauczor, M. Bendszus, C.M. Sommer, M.A. Möhlenbruch
American Journal of Neuroradiology Sep 2018, 39 (9) 1696-1702; DOI: 10.3174/ajnr.A5750
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