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Research ArticlePediatrics

Imaging Characteristics of Wingless Pathway Subgroup Medulloblastomas: Results from the German HIT/SIOP-Trial Cohort

A. Stock, M. Mynarek, T. Pietsch, S.M. Pfister, S.C. Clifford, T. Goschzik, D. Sturm, E.C. Schwalbe, D. Hicks, S. Rutkowski, B. Bison, M. Pham and M. Warmuth-Metz
American Journal of Neuroradiology November 2019, 40 (11) 1811-1817; DOI: https://doi.org/10.3174/ajnr.A6286
A. Stock
aFrom the Department of Neuroradiology (A.S., B.B., M.P., M.W.-M.), University Hospital Wuerzburg, Wuerzburg, Germany
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M. Mynarek
bDepartment of Pediatric Hematology and Oncology (M.M., S.R.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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T. Pietsch
cInstitute of Neuropathology (T.P., T.G.), DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany
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S.M. Pfister
dDepartment of Pediatric Hematology and Oncology (S.M.P.), Heidelberg University Hospital, Heidelberg, GermanyeDivision of Pediatric Neurooncology (S.M.P.), German Cancer Consortium, German Cancer Research Center, Heidelberg, GermanyfHopp Children's Cancer Heidelberg (S.M.P., D.S.), Heidelberg, Germany
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S.C. Clifford
gWolfson Childhood Cancer Research Centre (S.C.C., E.C.S., D.H.), Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
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T. Goschzik
cInstitute of Neuropathology (T.P., T.G.), DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany
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D. Sturm
fHopp Children's Cancer Heidelberg (S.M.P., D.S.), Heidelberg, Germany
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E.C. Schwalbe
gWolfson Childhood Cancer Research Centre (S.C.C., E.C.S., D.H.), Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UKhDepartment of Applied Sciences (E.C.S.), Northumbria University, Newcastle upon Tyne, UK
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D. Hicks
gWolfson Childhood Cancer Research Centre (S.C.C., E.C.S., D.H.), Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
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S. Rutkowski
bDepartment of Pediatric Hematology and Oncology (M.M., S.R.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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B. Bison
aFrom the Department of Neuroradiology (A.S., B.B., M.P., M.W.-M.), University Hospital Wuerzburg, Wuerzburg, Germany
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M. Pham
aFrom the Department of Neuroradiology (A.S., B.B., M.P., M.W.-M.), University Hospital Wuerzburg, Wuerzburg, Germany
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M. Warmuth-Metz
aFrom the Department of Neuroradiology (A.S., B.B., M.P., M.W.-M.), University Hospital Wuerzburg, Wuerzburg, Germany
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Abstract

BACKGROUND AND PURPOSE: In addition to the 4 histopathologically defined entities of medulloblastoma, 4 distinct genetically defined subgroups have been included in the World Health Organization classification of 2016. The smallest subgroup is the medulloblastoma with activated wingless pathway. The goal of this study was to identify a typical MR imaging morphology in a larger number of pediatric patients with wingless pathway medulloblastoma.

MATERIALS AND METHODS: From January 2001 to October 2017, of 75 patients with histologically confirmed and molecularly subgrouped wingless pathway medulloblastomas recruited to the German Pediatric Brain Tumor (HIT) trials, 38 patients (median age, 12.8 ± 4.6 years at diagnosis; 24 [63.2%] female) had preoperative imaging that passed the entry criteria for this study. Images were rated by the local standardized imaging criteria of the National Reference Center of Neuroradiology. Additionally, a modified laterality score was used to determine tumor localization and extension.

RESULTS: Twenty-eight of 38 (73.7%) were primary midline tumors but with a lateral tendency in 39.3%. One extensively eccentric midline tumor was rated by the laterality score as in an off-midline position. Five tumors were found in the cerebellopontine angle; 3, in the deep white matter; and 2, in a cerebellar hemisphere. Leptomeningeal dissemination was rare (11.5%). In 60.5%, intratumoral blood-degradation products were found, and 26.3% showed cysts with blood contents.

CONCLUSIONS: According to our observations, wingless pathway medulloblastomas are not preferentially off-midline tumors as postulated in previous studies with smaller wingless pathway medulloblastoma cohorts. Dense intratumoral blood-degradation products and cysts with blood contents are frequently found and might help to differentiate wingless pathway medulloblastoma from other medulloblastoma subtypes.

ABBREVIATIONS:

CMB
classic medulloblastoma
CPA
cerebellopontine angle
HIT
German abbreviation for brain tumor
LCMB
large-cell medulloblastoma (according to the World Health Organization classification of 2007)
LS
laterality score
MB
medulloblastoma
SHH
sonic hedgehog pathway
WHO
World Health Organization
WNT
wingless-activated
WNT-MB
WNT-activated medulloblastoma
  • © 2019 by American Journal of Neuroradiology
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American Journal of Neuroradiology: 40 (11)
American Journal of Neuroradiology
Vol. 40, Issue 11
1 Nov 2019
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Imaging Characteristics of Wingless Pathway Subgroup Medulloblastomas: Results from the German HIT/SIOP-Trial Cohort
A. Stock, M. Mynarek, T. Pietsch, S.M. Pfister, S.C. Clifford, T. Goschzik, D. Sturm, E.C. Schwalbe, D. Hicks, S. Rutkowski, B. Bison, M. Pham, M. Warmuth-Metz
American Journal of Neuroradiology Nov 2019, 40 (11) 1811-1817; DOI: 10.3174/ajnr.A6286

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Imaging Characteristics of Wingless Pathway Subgroup Medulloblastomas: Results from the German HIT/SIOP-Trial Cohort
A. Stock, M. Mynarek, T. Pietsch, S.M. Pfister, S.C. Clifford, T. Goschzik, D. Sturm, E.C. Schwalbe, D. Hicks, S. Rutkowski, B. Bison, M. Pham, M. Warmuth-Metz
American Journal of Neuroradiology Nov 2019, 40 (11) 1811-1817; DOI: 10.3174/ajnr.A6286
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