Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • For Authors
  • About Us
    • About AJNR
    • Editorial Board
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Other Publications
    • ajnr

User menu

  • Subscribe
  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

  • Subscribe
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Publication Preview--Ahead of Print
    • Past Issue Archive
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • For Authors
  • About Us
    • About AJNR
    • Editorial Board
    • American Society of Neuroradiology
  • Submit a Manuscript
  • Podcasts
    • Subscribe on iTunes
    • Subscribe on Stitcher
  • More
    • Subscribers
    • Permissions
    • Advertisers
    • Alerts
    • Feedback
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds
Research ArticlePatient Safety

Dose Reduction While Preserving Diagnostic Quality in Head CT: Advancing the Application of Iterative Reconstruction Using a Live Animal Model

F.D. Raslau, E.J. Escott, J. Smiley, C. Adams, D. Feigal, H. Ganesh, C. Wang and J. Zhang
American Journal of Neuroradiology November 2019, 40 (11) 1864-1870; DOI: https://doi.org/10.3174/ajnr.A6258
F.D. Raslau
aFrom the Departments of Radiology (F.D.R., E.J.E., C.A., D.F., H.G., J.Z.)bNeurology (F.D.R.)cNeurosurgery (F.D.R.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for F.D. Raslau
E.J. Escott
aFrom the Departments of Radiology (F.D.R., E.J.E., C.A., D.F., H.G., J.Z.)dOtolaryngology-Head and Neck Surgery (E.J.E.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E.J. Escott
J. Smiley
eLaboratory Animal Resources (J.S.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Smiley
C. Adams
aFrom the Departments of Radiology (F.D.R., E.J.E., C.A., D.F., H.G., J.Z.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Adams
D. Feigal
aFrom the Departments of Radiology (F.D.R., E.J.E., C.A., D.F., H.G., J.Z.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D. Feigal
H. Ganesh
aFrom the Departments of Radiology (F.D.R., E.J.E., C.A., D.F., H.G., J.Z.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for H. Ganesh
C. Wang
fBiostatistics (C.W.), University of Kentucky, Lexington, Kentucky
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Wang
J. Zhang
aFrom the Departments of Radiology (F.D.R., E.J.E., C.A., D.F., H.G., J.Z.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Zhang
  • Article
  • Figures & Data
  • Info & Metrics
  • References
  • PDF
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Abstract

BACKGROUND AND PURPOSE: Iterative reconstruction has promise in lowering the radiation dose without compromising image quality, but its full potential has not yet been realized. While phantom studies cannot fully approximate the subjective effects on image quality, live animal models afford this assessment. We characterize dose reduction in head CT by applying advanced modeled iterative reconstruction (ADMIRE) in a live ovine model while evaluating preservation of gray-white matter detectability and image texture compared with filtered back-projection.

MATERIALS AND METHODS: A live sheep was scanned on a Force CT scanner (Siemens) at 12 dose levels (82–982 effective mAs). Images were reconstructed with filtered back-projection and ADMIRE (strengths, 1–5). A total of 72 combinations (12 doses × 6 reconstructions) were evaluated qualitatively for resemblance to the reference image (highest dose with filtered back-projection) using 2 metrics: detectability of gray-white matter differentiation and noise-versus-smoothness in image texture. Quantitative analysis for noise, SNR, and contrast-to-noise was also performed across all dose-strength combinations.

RESULTS: Both qualitative and quantitative results confirm that gray-white matter differentiation suffers at a lower dose but recovers when complemented by higher iterative reconstruction strength, and image texture acquires excessive smoothness with a higher iterative reconstruction strength but recovers when complemented by dose reduction. Image quality equivalent to the reference image is achieved by a 58% dose reduction with ADMIRE-5.

CONCLUSIONS: An approximately 60% dose reduction may be possible while preserving diagnostic quality with the appropriate dose-strength combination. This in vivo study can serve as a useful guide for translating the full implementation of iterative reconstruction in clinical practice.

ABBREVIATIONS:

ADMIRE
advanced modeled iterative reconstruction
CNR
contrast-to-noise ratio
FBP
filtered back-projection
IR
iterative reconstruction
  • © 2019 by American Journal of Neuroradiology
View Full Text

Log in using your username and password

Forgot your user name or password?
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 40 (11)
American Journal of Neuroradiology
Vol. 40, Issue 11
1 Nov 2019
  • Complete Issue (PDF)
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Dose Reduction While Preserving Diagnostic Quality in Head CT: Advancing the Application of Iterative Reconstruction Using a Live Animal Model
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
Citation Tools
Dose Reduction While Preserving Diagnostic Quality in Head CT: Advancing the Application of Iterative Reconstruction Using a Live Animal Model
F.D. Raslau, E.J. Escott, J. Smiley, C. Adams, D. Feigal, H. Ganesh, C. Wang, J. Zhang
American Journal of Neuroradiology Nov 2019, 40 (11) 1864-1870; DOI: 10.3174/ajnr.A6258

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Dose Reduction While Preserving Diagnostic Quality in Head CT: Advancing the Application of Iterative Reconstruction Using a Live Animal Model
F.D. Raslau, E.J. Escott, J. Smiley, C. Adams, D. Feigal, H. Ganesh, C. Wang, J. Zhang
American Journal of Neuroradiology Nov 2019, 40 (11) 1864-1870; DOI: 10.3174/ajnr.A6258
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

Related Articles

  • No related articles found.
  • Scopus
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Safety and Diagnostic Efficacy of Gadobenate Dimeglumine in MRI of the Brain and Spine of Neonates and Infants
  • Evaluation of Lower-Dose Spiral Head CT for Detection of Intracranial Findings Causing Neurologic Deficits
Show more Patient Safety

Similar Articles

Advertisement

News and Updates

  • 2018 Lucien Levy Best Research Article Award
  • Thanks to our 2019 Distinguished Reviewers
  • Press Releases

Resources

  • Evidence-Based Medicine Level Guide
  • How to Participate in a Tweet Chat
  • AJNR Podcast Archive
  • Ideas for Publicizing Your Research
  • Librarian Resources
  • Terms and Conditions

Opportunities

  • Share Your Art in Perspectives
  • Get Peer Review Credit from Publons
  • Moderate a Tweet Chat

American Society of Neuroradiology

  • Neurographics
  • ASNR Annual Meeting
  • Fellowship Portal
  • Position Statements

© 2019 by the American Society of Neuroradiology | Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire