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Research ArticlePediatrics

Comparison of CSF and MRI Findings among Neonates and Infants with E coli or Group B Streptococcal Meningitis

S.F. Kralik, M.K. Kukreja, M.J. Paldino, N.K. Desai and J.G. Vallejo
American Journal of Neuroradiology August 2019, 40 (8) 1413-1417; DOI: https://doi.org/10.3174/ajnr.A6134
S.F. Kralik
aFrom the Department of Radiology (S.F.K., M.K.K., M.J.P., N.K.D.), Texas Children's Hospital, Houston, Texas
bIndiana University Riley Children's Hospital (S.F.K.), Indianapolis, Indiana
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M.K. Kukreja
aFrom the Department of Radiology (S.F.K., M.K.K., M.J.P., N.K.D.), Texas Children's Hospital, Houston, Texas
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M.J. Paldino
aFrom the Department of Radiology (S.F.K., M.K.K., M.J.P., N.K.D.), Texas Children's Hospital, Houston, Texas
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N.K. Desai
aFrom the Department of Radiology (S.F.K., M.K.K., M.J.P., N.K.D.), Texas Children's Hospital, Houston, Texas
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J.G. Vallejo
cDepartment of Pediatrics (J.G.V.), Baylor College of Medicine, Houston, Texas.
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    Fig 1.

    A 12-day-old neonate with GBS meningitis. Axial DWI demonstrates multifocal areas of diffusion restriction (ADC not shown) in the parenchyma, consistent with infarcts and cerebritis.

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    Fig 2.

    A 19-day-old neonate with E coli meningitis. A, Axial T2-weighted image demonstrates disproportionate enlargement of the lateral ventricles relative to the sulci, consistent with hydrocephalus. B, Axial DWI demonstrates areas of diffusion restriction (ADC not shown) in the ventricles (arrows), consistent with intraventricular purulent material. C, Axial T1-weighted postcontrast image demonstrates abnormal ependymal enhancement along the lateral ventricles (arrows).

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  • Comparison of CSF and MRI findings in patients with GBS and E coli meningitisa

    FindingGBS (n = 57)E coli (n = 50)P Valueb
    CSF corrected WBC count (cells/μL)3116 ± 50584770 ± 126841.00
    CSF glucose (mg/dL)35.2 ± 21.834.0 ± 24.61.00
    CSF total protein (mg/dL)517.8 ± 867.0910.7 ± 1414.21.00
    Leptomeningeal enhancement49%46%1.00
    Cerebritis21%7%.77
    Ependymal enhancement7%28%.063
    Abscess/granuloma2%2%1.00
    Subdural effusion49%26%.24
    Hemorrhage33%46%1.00
    Extra-axial purulent material37%38%1.00
    Intraventricular purulent material9%22%.84
    Sinus thrombosis11%4%1.00
    Hydrocephalus0%22%.0014
    Infarct40%14%.038
    • ↵a CSF values are listed as mean ± SD.

    • ↵b P value is adjusted for multiple comparisons (n = 14).

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American Journal of Neuroradiology: 40 (8)
American Journal of Neuroradiology
Vol. 40, Issue 8
1 Aug 2019
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Comparison of CSF and MRI Findings among Neonates and Infants with E coli or Group B Streptococcal Meningitis
S.F. Kralik, M.K. Kukreja, M.J. Paldino, N.K. Desai, J.G. Vallejo
American Journal of Neuroradiology Aug 2019, 40 (8) 1413-1417; DOI: 10.3174/ajnr.A6134

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Comparison of CSF and MRI Findings among Neonates and Infants with E coli or Group B Streptococcal Meningitis
S.F. Kralik, M.K. Kukreja, M.J. Paldino, N.K. Desai, J.G. Vallejo
American Journal of Neuroradiology Aug 2019, 40 (8) 1413-1417; DOI: 10.3174/ajnr.A6134
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