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Research ArticlePediatrics
Open Access

COVID-19-Associated Cytotoxic Lesions of the Corpus Callosum

P. Gaur, L. Dixon, B. Jones, H. Lyall and W. Jan
American Journal of Neuroradiology October 2020, 41 (10) 1905-1907; DOI: https://doi.org/10.3174/ajnr.A6713
P. Gaur
aFrom the Departments of Imaging (P.G., L.D., B.J., W.J.)
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L. Dixon
aFrom the Departments of Imaging (P.G., L.D., B.J., W.J.)
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B. Jones
aFrom the Departments of Imaging (P.G., L.D., B.J., W.J.)
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H. Lyall
bPaediatric Infectious Diseases (H.L.), Imperial Healthcare NHS Trust, Charing Cross Hospital, London, United Kingdom
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W. Jan
aFrom the Departments of Imaging (P.G., L.D., B.J., W.J.)
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Abstract

SUMMARY: There are very limited published data on the neurologic complications associated with coronavirus disease 2019 (COVID-19) in the pediatric population. Here we present the first 2 pediatric cases of presumed COVID-19 related cytotoxic lesions of the corpus callosum. Similar to reports in adults, these cases suggest that the COVID-19 infection in children may rarely mediate a hyperinflammatory response that can cause CNS pathology. As the pandemic continues further, the presentation of cytotoxic lesions of the corpus callosum should prompt radiologists to consider COVID-19, among other known causes.

ABBREVIATIONS:

CLOCC
cytotoxic lesions of the corpus callosum
COVID-19
coronavirus disease 2019
CRP
C-reactive protein
RT-PCR
real-time reverse transcriptase polymerase chain reaction
SARS-CoV-2
Severe Acute Respiratory Syndrome coronavirus 2
  • © 2020 by American Journal of Neuroradiology

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American Journal of Neuroradiology: 41 (10)
American Journal of Neuroradiology
Vol. 41, Issue 10
1 Oct 2020
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COVID-19-Associated Cytotoxic Lesions of the Corpus Callosum
P. Gaur, L. Dixon, B. Jones, H. Lyall, W. Jan
American Journal of Neuroradiology Oct 2020, 41 (10) 1905-1907; DOI: 10.3174/ajnr.A6713

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COVID-19-Associated Cytotoxic Lesions of the Corpus Callosum
P. Gaur, L. Dixon, B. Jones, H. Lyall, W. Jan
American Journal of Neuroradiology Oct 2020, 41 (10) 1905-1907; DOI: 10.3174/ajnr.A6713
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  • Clinical Features of Cytotoxic Lesions of the Corpus Callosum Associated with Aneurysmal Subarachnoid Hemorrhage
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