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Research ArticleInterventional

Treatment Outcomes of Endovascular Embolization Only in Patients with Unruptured Brain Arteriovenous Malformations: A Subgroup Analysis of ARUBA (A Randomized Trial of Unruptured Brain Arteriovenous Malformations)

A.I. Qureshi, O. Saeed, S. Sahito, I. Lobanova, J. Liaqat, F. Siddiq and C.R. Gomez
American Journal of Neuroradiology April 2020, 41 (4) 676-680; DOI: https://doi.org/10.3174/ajnr.A6443
A.I. Qureshi
aFrom the Zeenat Qureshi Stroke Institute (A.I.Q., O.S., S.S., I.L., J.L.), St. Cloud, Minnesota
bDepartment of Neurology (A.I.Q., C.R.G.) and
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O. Saeed
aFrom the Zeenat Qureshi Stroke Institute (A.I.Q., O.S., S.S., I.L., J.L.), St. Cloud, Minnesota
dDepartment of Neurology (O.S.), University of Tennessee Health Science Center, Memphis, Tennessee
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S. Sahito
aFrom the Zeenat Qureshi Stroke Institute (A.I.Q., O.S., S.S., I.L., J.L.), St. Cloud, Minnesota
eDepartment of Neurology (S.S.), JFK Medical Center, Edison, New Jersey
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I. Lobanova
aFrom the Zeenat Qureshi Stroke Institute (A.I.Q., O.S., S.S., I.L., J.L.), St. Cloud, Minnesota
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J. Liaqat
aFrom the Zeenat Qureshi Stroke Institute (A.I.Q., O.S., S.S., I.L., J.L.), St. Cloud, Minnesota
fPakistan Emirates Military Hospital (J.L.), Rawalpindi, Pakistan.
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F. Siddiq
cDivision of Neurological Surgery (F.S.), University of Missouri, Colombia, Missouri
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C.R. Gomez
bDepartment of Neurology (A.I.Q., C.R.G.) and
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Abstract

BACKGROUND AND PURPOSE: Endovascular embolization only has been advocated for treatment of brain arteriovenous malformations in recent trials. Our aim was to evaluate the results of embolization only in a cohort of patients who were enrolled in the A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA) study at 39 clinical sites in 9 countries.

MATERIALS AND METHODS: We analyzed the rates and severity of stroke and death in patients who underwent embolization only. Events were identified through in-person neurologic follow-up visits performed at 6-month intervals during the first 2 years and annually, with telephone contact every 6 months thereafter. All event-related data were reviewed by independent adjudicators.

RESULTS: Among 30 patients who had embolization planned, 26 underwent embolization only. A total of 13 stroke events were reported in the follow-up period among 26 subjects (ischemic, hemorrhagic, or both in 4, 7, and 2 subjects, respectively). The adverse event occurred after the first embolization in 11 of 13 patients. One patient had a major motor deficit, and 2 patients developed major visual field deficits. One event was fatal. The modified Rankin Scale score was 0–2 at last follow-up in 11 of the 12 stroke survivors. Estimated stroke-free survival was 46% at 12 months.

CONCLUSIONS: Although the rates of stroke and/or death were high in patients treated with embolization only in ARUBA, the rates of favorable outcomes following stroke were high during follow-up.

ABBREVIATION:

BAVM
brain arteriovenous malformations
  • © 2020 by American Journal of Neuroradiology
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American Journal of Neuroradiology: 41 (4)
American Journal of Neuroradiology
Vol. 41, Issue 4
1 Apr 2020
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Treatment Outcomes of Endovascular Embolization Only in Patients with Unruptured Brain Arteriovenous Malformations: A Subgroup Analysis of ARUBA (A Randomized Trial of Unruptured Brain Arteriovenous Malformations)
A.I. Qureshi, O. Saeed, S. Sahito, I. Lobanova, J. Liaqat, F. Siddiq, C.R. Gomez
American Journal of Neuroradiology Apr 2020, 41 (4) 676-680; DOI: 10.3174/ajnr.A6443

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Treatment Outcomes of Endovascular Embolization Only in Patients with Unruptured Brain Arteriovenous Malformations: A Subgroup Analysis of ARUBA (A Randomized Trial of Unruptured Brain Arteriovenous Malformations)
A.I. Qureshi, O. Saeed, S. Sahito, I. Lobanova, J. Liaqat, F. Siddiq, C.R. Gomez
American Journal of Neuroradiology Apr 2020, 41 (4) 676-680; DOI: 10.3174/ajnr.A6443
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