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Abstract

MR of brain radiation injury: experimental studies in cats.

C Hecht-Leavitt, R I Grossman, W J Curran, J T McGrath, D N Biery, P M Joseph and D F Nelson
American Journal of Neuroradiology May 1987, 8 (3) 427-430;
C Hecht-Leavitt
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R I Grossman
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W J Curran Jr
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J T McGrath
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D N Biery
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P M Joseph
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D F Nelson
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Abstract

Two of six cats receiving small-field, single-dose, brain irradiation of 35 Gy with 6 MeV photons developed brain abnormalities in the irradiated area on MR images at 6 and 8 months, respectively, after treatment. The lesions were of high intensity on T2-weighted images and did not enhance after IV administration of gadolinium-DTPA. An additional lesion in one of these cats displayed high signal on T2-weighted images and enhanced on T1-weighted images after IV gadolinium-DTPA. Pathologic correlation revealed that the nonenhancing T2-weighted lesions consisted of edema or demyelinated regions without inflammation while the gadolinium-enhanced lesion demonstrated necrosis with inflammatory infiltrate. Focal brain irradiation may produce noninflammatory demyelination and necrosis. These histologic entities may be potentially distinguished on MR with IV gadolinium-DTPA.

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American Journal of Neuroradiology
Vol. 8, Issue 3
1 May 1987
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MR of brain radiation injury: experimental studies in cats.
C Hecht-Leavitt, R I Grossman, W J Curran, J T McGrath, D N Biery, P M Joseph, D F Nelson
American Journal of Neuroradiology May 1987, 8 (3) 427-430;

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MR of brain radiation injury: experimental studies in cats.
C Hecht-Leavitt, R I Grossman, W J Curran, J T McGrath, D N Biery, P M Joseph, D F Nelson
American Journal of Neuroradiology May 1987, 8 (3) 427-430;
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