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Abstract

MR of acute experimental allergic encephalomyelitis.

R I Grossman, R P Lisak, P J Macchi and P M Joseph
American Journal of Neuroradiology November 1987, 8 (6) 1045-1048;
R I Grossman
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104.
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R P Lisak
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104.
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P J Macchi
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104.
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P M Joseph
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104.
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Abstract

Acute experimental allergic encephalomyelitis, an animal model of CNS inflammatory and demyelinating disease, was produced in guinea pigs and imaged with MR. Correlation of histopathology with MR revealed acute mononuclear perivascular inflammatory changes and edema corresponding to the high-intensity abnormalities observed on long repetition time (TR) images. Our results suggest that in acute multiple sclerosis the high intensity noted on long TR images may be secondary to associated inflammatory changes rather than to demyelination.

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American Journal of Neuroradiology
Vol. 8, Issue 6
1 Nov 1987
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MR of acute experimental allergic encephalomyelitis.
R I Grossman, R P Lisak, P J Macchi, P M Joseph
American Journal of Neuroradiology Nov 1987, 8 (6) 1045-1048;

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MR of acute experimental allergic encephalomyelitis.
R I Grossman, R P Lisak, P J Macchi, P M Joseph
American Journal of Neuroradiology Nov 1987, 8 (6) 1045-1048;
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