More articles from ADULT BRAIN
- Gadolinium-Enhanced Susceptibility-Weighted Imaging in Multiple Sclerosis: Optimizing the Recognition of Active Plaques for Different MR Imaging Sequences
The authors analyzed the accuracy of gadolinium SWI for detecting the imaging evidence of active inflammation on MS plaques when a BBB dysfunction was demonstrated by a focal gadolinium-enhanced lesion and compared this technique with gadolinium-enhanced T1 spin-echo and T1 spin-echo with magnetization transfer contrast sequences. Differences in BBB dysfunction were evident in the 103 patients among gadolinium SWI, gadolinium T1 spin-echo, and gadolinium T1 magnetization transfer contrast. Gadolinium T1 magnetization transfer contrast demonstrated the highest number of active demyelinating plaques. Gadolinium SWI was highly correlated with gadolinium T1 magnetization transfer contrast in depicting acute demyelinating plaques and these techniques provided better performance compared with gadolinium T1 spin-echo.
- Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI
In this technical report, the authors used MR myelography to demonstrate the feasibility of T1 mapping to quantify contrast concentration to analyze glymphatic flow in man. There is increasing interest in its use as a biomarker and potential therapeutic target in Alzheimer disease.