Case of the Week
Section Editors: Matylda Machnowska1 and Anvita Pauranik2
1University of Toronto, Toronto, Ontario, Canada
2BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada
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December 1, 2008
Solitary Fibrous Tumor
- Solitary Fibrous Tumors (SFT) of the central nervous system are rare.
- They usually present as dural based masses, rarely seen within the ventricles; parenchymal brain and spinal cord have been reported in the literature.
- Intraventricular SFT arise from the perivascular connective tissues of the choroid plexus.
- Can be solid or cystic, have low T2 signal intensity (due to areas composed of interlacing bundles of spindle cells or collagenous septations), which is considered to be a suggestive feature of the diagnosis.
- On immunohistochemistry, SFT show strong positivity for CD34, bcl'2, and vimentin and negativity for EMA and S'100.