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Research ArticleBRAIN

Suspicious Neuroimaging Pattern of Thrombotic Microangiopathy

T.N. Ellchuk, L.M. Shah, R.H. Hewlett and A.G. Osborn
American Journal of Neuroradiology February 2011, DOI: https://doi.org/10.3174/ajnr.A2351
T.N. Ellchuk
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L.M. Shah
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R.H. Hewlett
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A.G. Osborn
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Abstract

SUMMARY: The TMAs are a group of microvascular occlusive disorders characterized by thrombocytopenia and intravascular hemolysis. Literature review reveals a spectrum of neuroimaging findings, including a single case report of multifocal hemorrhagic infarctions. We present a series of 12 patients with TMA demonstrating a similar pattern of multifocal cortical and subcortical hemorrhagic infarctions.

Footnotes

  • ADC
    apparent diffusion coefficient
    AML
    acute myelogenous leukemia
    CLL
    chronic lymphocytic leukemia
    CNS
    central nervous system
    CTV
    CT venography
    DIC
    disseminated intravascular coagulation
    DWI
    diffusion-weighted imaging
    GRE
    gradient recalled-echo
    HIV
    human immunodeficiency virus
    HUS
    hemolytic uremic syndrome
    mHTN
    malignant hypertension
    MRI
    MR imaging
    MRV
    MR venography
    PRES
    posterior reversible encephalopathy syndrome
    SWI
    susceptibility-weighted imaging
    TMA
    thrombotic microangiopathy
    TTP
    thrombotic thrombocytopenic purpura
    vWF
    von Willebrand factor

  • © 2011 American Society of Neuroradiology
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Suspicious Neuroimaging Pattern of Thrombotic Microangiopathy
T.N. Ellchuk, L.M. Shah, R.H. Hewlett, A.G. Osborn
American Journal of Neuroradiology Feb 2011, DOI: 10.3174/ajnr.A2351

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Suspicious Neuroimaging Pattern of Thrombotic Microangiopathy
T.N. Ellchuk, L.M. Shah, R.H. Hewlett, A.G. Osborn
American Journal of Neuroradiology Feb 2011, DOI: 10.3174/ajnr.A2351
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