Magnetization Transfer Imaging in Premanifest and Manifest Huntington Disease: A 2-Year Follow-Up
Abstract
BACKGROUND AND PURPOSE: MTI is a quantitative MR imaging technique that has recently demonstrated structural integrity differences between controls and patients with HD. Potentially, MTI can be used as a biomarker for monitoring disease progression. To establish the value of MTI as a biomarker, we aimed to examine the change in these measures during the course of HD.
MATERIALS AND METHODS: From the Leiden TRACK-HD study, 25 controls, 21 premanifest gene carriers, and 21 patients with manifest HD participated at baseline and during a 2-year follow-up visit. Brain segmentation of the cortical gray matter, white matter, caudate nucleus, putamen, pallidum, thalamus, amygdala, and hippocampus was performed by using the automated tools FAST and FIRST in FSL. Individual MTR values were calculated from these regions, and MTR histograms were constructed.
RESULTS: In the premanifest HD group stage “far from disease onset,” a significant increase in MTR peak height of the putamen was observed with time. During the manifest HD stage, neither the mean MTR nor the MTR peak height showed a significant change during a 2-year follow-up.
CONCLUSIONS: MTI-derived measures are not suitable for monitoring in Huntington disease during a 2-year period because there was no decrease in structural integrity detected in any of the manifest HD groups longitudinally. The finding of increased putaminal MTR peak height in the premanifest far from disease onset group could relate to a predegenerative process, compensatory mechanisms, or aberrant development but should be interpreted with caution until future studies confirm this finding.
Abbreviations
- HD
- Huntington disease
- HD 1
- manifest HD stage 1
- HD 2
- manifest HD stage 2
- MTI
- magnetization transfer imaging
- MTR
- magnetization-transfer ratio
- © 2013 American Society of Neuroradiology
Jump to section
Related Articles
Cited By...
This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.
- Monica Banez-Coronel, Laura P.W. RanumLaboratory Investigation 2019 99 7
- Sudhakar Tummala, Bhaswati Roy, Bumhee Park, Daniel W. Kang, Mary A. Woo, Ronald M. Harper, Rajesh KumarJournal of Neuroscience Research 2016 94 10
- Nicola Tambasco, Pasquale Nigro, Michele Romoli, Simone Simoni, Lucilla Parnetti, Paolo CalabresiJournal of the Neurological Sciences 2015 353 1-2
- Alex M. Pagnozzi, Jurgen Fripp, Stephen E. RoseNeuroImage 2019 201
- Ralph Andre, Rachael I. Scahill, Salman Haider, Sarah J. TabriziDrug Discovery Today 2014 19 7
- Heather Wilson, George Dervenoulas, Marios Politis2018 142
- Takeshi Nakano, Shinji Ono, Junji Yamaguchi, Ryu Sugimoto, Naohiro Yamaguchi, Yoshiro Morimoto, Tatsuya Kubo, Hiroki Ozawa, Naohiro KurotakiJournal of Neurology 2013 260 1
- Jean-Baptiste Pérot, Marina Célestine, Marco Palombo, Marc Dhenain, Sandrine Humbert, Emmanuel Brouillet, Julien FlamentHuman Molecular Genetics 2022 31 21