Research ArticleBRAIN
Open Access
Neurovascular Manifestations in Hereditary Hemorrhagic Telangiectasia: Imaging Features and Genotype-Phenotype Correlations
T. Krings, H. Kim, S. Power, J. Nelson, M.E. Faughnan, W.L. Young and K.G. ter Brugge
American Journal of Neuroradiology January 2015, DOI: https://doi.org/10.3174/ajnr.A4210
T. Krings
From the Division of Neuroradiology (T.K., S.P., K.G.t.B.), Department of Medical Imaging, and Division of Neurosurgery (T.K.), Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Anesthesia and Perioperative Care (H.K., J.N., W.L.Y.), Center for Cerebrovascular Research, and Department of Epidemiology and Biostatistics (H.K.), University of California San Francisco, San Francisco, California; Division of Respirology (M.E.F.), Department of Medicine and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; and Division of Respirology (M.E.F.), Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
H. Kim
From the Division of Neuroradiology (T.K., S.P., K.G.t.B.), Department of Medical Imaging, and Division of Neurosurgery (T.K.), Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Anesthesia and Perioperative Care (H.K., J.N., W.L.Y.), Center for Cerebrovascular Research, and Department of Epidemiology and Biostatistics (H.K.), University of California San Francisco, San Francisco, California; Division of Respirology (M.E.F.), Department of Medicine and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; and Division of Respirology (M.E.F.), Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
S. Power
From the Division of Neuroradiology (T.K., S.P., K.G.t.B.), Department of Medical Imaging, and Division of Neurosurgery (T.K.), Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Anesthesia and Perioperative Care (H.K., J.N., W.L.Y.), Center for Cerebrovascular Research, and Department of Epidemiology and Biostatistics (H.K.), University of California San Francisco, San Francisco, California; Division of Respirology (M.E.F.), Department of Medicine and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; and Division of Respirology (M.E.F.), Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
J. Nelson
From the Division of Neuroradiology (T.K., S.P., K.G.t.B.), Department of Medical Imaging, and Division of Neurosurgery (T.K.), Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Anesthesia and Perioperative Care (H.K., J.N., W.L.Y.), Center for Cerebrovascular Research, and Department of Epidemiology and Biostatistics (H.K.), University of California San Francisco, San Francisco, California; Division of Respirology (M.E.F.), Department of Medicine and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; and Division of Respirology (M.E.F.), Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
M.E. Faughnan
From the Division of Neuroradiology (T.K., S.P., K.G.t.B.), Department of Medical Imaging, and Division of Neurosurgery (T.K.), Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Anesthesia and Perioperative Care (H.K., J.N., W.L.Y.), Center for Cerebrovascular Research, and Department of Epidemiology and Biostatistics (H.K.), University of California San Francisco, San Francisco, California; Division of Respirology (M.E.F.), Department of Medicine and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; and Division of Respirology (M.E.F.), Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
W.L. Young
From the Division of Neuroradiology (T.K., S.P., K.G.t.B.), Department of Medical Imaging, and Division of Neurosurgery (T.K.), Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Anesthesia and Perioperative Care (H.K., J.N., W.L.Y.), Center for Cerebrovascular Research, and Department of Epidemiology and Biostatistics (H.K.), University of California San Francisco, San Francisco, California; Division of Respirology (M.E.F.), Department of Medicine and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; and Division of Respirology (M.E.F.), Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
K.G. ter Brugge
From the Division of Neuroradiology (T.K., S.P., K.G.t.B.), Department of Medical Imaging, and Division of Neurosurgery (T.K.), Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Anesthesia and Perioperative Care (H.K., J.N., W.L.Y.), Center for Cerebrovascular Research, and Department of Epidemiology and Biostatistics (H.K.), University of California San Francisco, San Francisco, California; Division of Respirology (M.E.F.), Department of Medicine and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; and Division of Respirology (M.E.F.), Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Article Information
PubMed
Published By
Print ISSN
Online ISSN
History
- Published online January 8, 2015.
Article Versions
- You are currently viewing a Latest version of this article (January 8, 2015 - 07:14).
- View the most recent version of this article
Copyright & Usage
© 2015 American Society of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org
Author Information
- From the Division of Neuroradiology (T.K., S.P., K.G.t.B.), Department of Medical Imaging, and Division of Neurosurgery (T.K.), Department of Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Anesthesia and Perioperative Care (H.K., J.N., W.L.Y.), Center for Cerebrovascular Research, and Department of Epidemiology and Biostatistics (H.K.), University of California San Francisco, San Francisco, California; Division of Respirology (M.E.F.), Department of Medicine and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; and Division of Respirology (M.E.F.), Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
- Please address correspondence to Timo Krings, MD, PhD, Division of Neuroradiology, Department of Medical Imaging, Toronto Western Hospital, 399 Bathurst St, 3 McL, Toronto, ON, M5T 2S8, Canada; e-mail: Timo.Krings{at}uhn.ca
↵† Deceased.
Altmetrics
Cited By...
This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.
- Colin P. Derdeyn, Gregory J. Zipfel, Felipe C. Albuquerque, Daniel L. Cooke, Edward Feldmann, Jason P. Sheehan, James C. TornerStroke 2017 48 8
- Waleed Brinjikji, Vivek N. Iyer, Christopher P. Wood, Giuseppe LanzinoJournal of Neurosurgery 2017 127 2
- David S. Priemer, Alexander O. Vortmeyer, Shaobo Zhang, Hsim Yee Chang, Kendra L. Curless, Liang ChengHuman Pathology 2019 89
- W. Brinjikji, V. N. Iyer, V. Yamaki, G. Lanzino, H. J. Cloft, K. R. Thielen, K. L. Swanson, C. P. WoodAmerican Journal of Neuroradiology 2016 37 8
- Waleed Brinjikji, Vivek N. Iyer, Thomas Sorenson, Giuseppe LanzinoStroke 2015 46 11
- E. M. de Gussem, C. P. Edwards, A. E. Hosman, C. J. J. Westermann, R. J. Snijder, M. E. Faughnan, J. J. MagerOrphanet Journal of Rare Diseases 2016 11 1
- Guillaume Saliou, Mélanie Eyries, Marta Iacobucci, Jean‐François Knebel, Marie‐Christine Waill, Florence Coulet, Augustin Ozanne, Florent SoubrierAnnals of Neurology 2017 82 6
- Omer F. Eker, Edoardo Boccardi, Ulrich Sure, Maneesh C. Patel, Saverio Alicante, Ali Alsafi, Nicola Coote, Freya Droege, Olivier Dupuis, Annette Dam Fialla, Bryony Jones, Ujwal Kariholu, Anette D. Kjeldsen, David Lefroy, Gennaro M. Lenato, Hans Jurgen Mager, Guido Manfredi, Troels H. Nielsen, Fabio Pagella, Marco C. Post, Catherine Rennie, Carlo Sabbà, Patrizia Suppressa, Pernille M. Toerring, Sara Ugolini, Elisabetta Buscarini, Sophie Dupuis-Girod, Claire L. ShovlinOrphanet Journal of Rare Diseases 2020 15 1
- Masaki KOMIYAMANeurologia medico-chirurgica 2016 56 6
- Steven W. Hetts, Joseph T. Shieh, Michael A. Ohliger, Miles B. ConradRadiology 2021 300 1
- Ethan A. Winkler, Alex Y. Lu, Kunal P. Raygor, Joseph R. Linzey, Soren Jonzzon, Brian V. Lien, W. Caleb Rutledge, Adib A. AblaNeurochemistry International 2019 126
- Reade De Leacy, Sameer A Ansari, Clemens M Schirmer, Daniel L Cooke, Charles J Prestigiacomo, Ketan R Bulsara, Steven W HettsJournal of NeuroInterventional Surgery 2022 14 11
- Jesse M. Klostranec, Long Chen, Shobhit Mathur, Jamie McDonald, Marie E. Faughnan, Felix Ratjen, Timo KringsNeurology 2019 92 1
- Ali Tayebi Meybodi, Helen Kim, Jeffrey Nelson, Steven W Hetts, Timo Krings, Karel G terBrugge, Marie E Faughnan, Michael T LawtonNeurosurgery 2018 82 1
- Felipe S. Barros, Victor Hugo R. Marussi, Lázaro L.F. Amaral, Antônio José da Rocha, Christiane M.S. Campos, Leonardo F. Freitas, Thierry A.G.M. Huisman, Bruno P. SoaresTopics in Magnetic Resonance Imaging 2018 27 6
- Pradeep Goyal, Rajiv Mangla, Sonali Gupta, Ajay Malhotra, Jeevak Almast, Joshua Sapire, Balasubramanya KolarJournal of Neuroimaging 2019 29 2
- Ludmila Pawlikowska, Jeffrey Nelson, Diana E. Guo, Charles E. McCulloch, Michael T. Lawton, Helen Kim, Marie E. FaughnanMolecular Genetics & Genomic Medicine 2018 6 3
- Omid Bameri, Morteza Salarzaei, Fateme ParooieInterventional Neuroradiology 2021 27 4
- Waleed Brinjikji, Vivek N Iyer, Giuseppe Lanzino, Kent R Thielen, Christopher P WoodJournal of NeuroInterventional Surgery 2017 9 1
- Kshitij Mankad, Asthik Biswas, Maria Camilla Rossi Espagnet, Luke Dixon, Nihaal Reddy, Ai Peng Tan, Ozgur Oztekin, Felice D’Arco, Karuna Shekdar, Prakash Muthusami, Fergus Robertson, Stacy Goergen, Winston ChongNeuroradiology 2020 62 1
- Alexandra Kilian, Giuseppe Latino, Andrew White, Dewi Clark, Murali Chakinala, Felix Ratjen, Jamie McDonald, Kevin Whitehead, James Gossage, Doris Lin, Katharine Henderson, Jeffrey Pollak, Justin McWilliams, Helen Kim, Michael Lawton, Marie FaughnanJournal of Clinical Medicine 2020 9 9
- Joan D. Beckman, Quefeng Li, Samuel T. Hester, Ofri Leitner, Karen L. Smith, Raj S. KasthuriOrphanet Journal of Rare Diseases 2020 15 1
- Nicholas T. Gamboa, Evan J. Joyce, Ilyas Eli, Min S. Park, Philipp Taussky, Richard H. Schmidt, Jamie McDonald, Kevin J. Whitehead, M. Yashar S. KalaniJournal of Clinical Neuroscience 2018 51
- M. Vella, M.D. Alexander, M.C. Mabray, D.L. Cooke, M.R. Amans, C.M. Glastonbury, H. Kim, M.W. Wilson, D.E. Langston, M.B. Conrad, S.W. HettsAmerican Journal of Neuroradiology 2020 41 6
- Alexandra Kilian, Marianne S Clancy, Scott Olitsky, James R Gossage, Marie E FaughnanVascular Medicine 2021 26 1
- Lauren A. Beslow, Jake Breimann, Daniel J. Licht, Jake Waldman, Samantha Fallacaro, Reed E. Pyeritz, Elizabeth Goldmuntz, Arastoo VossoughPediatric Neurology 2020 110
- Jillian W. Andrejecsk, Anna E. Hosman, Luisa M. Botella, Claire L. Shovlin, Helen M. Arthur, Sophie Dupuis-Girod, Elisabetta Buscarini, Christopher C. W. Hughes, Franck Lebrin, Christine L. Mummery, Marco C. Post, Johannes J. MagerAngiogenesis 2018 21 1
- Elise Drapé, Typhaine Anquetil, Bruno Larrivée, Alexandre DubracFrontiers in Human Neuroscience 2022 16
- Abbas Rattani, Michael C. Dewan, Vickie Hannig, Robert P. Naftel, John C. Wellons, Lori C. JordanJournal of Neurosurgery: Pediatrics 2017 20 2
- Blaine L. Hart, Marc C. Mabray, Leslie Morrison, Kevin J. Whitehead, Helen KimClinical Imaging 2021 75
- Stephanie Sobrepera, Eric Monroe, Joseph J. Gemmete, Danial Hallam, Jason W. Pinchot, Claire KaufmanCVIR Endovascular 2021 4 1
- Chul Han, Michael J. Lang, Candice L. Nguyen, Ernesto Luna Melendez, Shwetal Mehta, Gregory H. Turner, Michael T. Lawton, S. Paul OhJournal of Neurosurgery 2022 137 1
- Stanislas J. Smajda, Michael Söderman, Georg Dorfmüller, Nathalie Dorison, Marie-Claire Nghe, Georges L. RodeschBrain Communications 2022 4 2
- Alexandra Kilian, Giuseppe A. Latino, Andrew J. White, Felix Ratjen, Jamie McDonald, Kevin J. Whitehead, James R. Gossage, Timo Krings, Michael T. Lawton, Helen Kim, Marie E. FaughnanJournal of Clinical Medicine 2023 12 7
- Joel Agarwal, Jennifer LaBranche, Simran Dhillon, W. Ted Allison, Thomas Jeerakathil, Dilini VethanayagamCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 2023 50 4
- Sreenivasulu Kilari, Ying Wang, Avishek Singh, Rondell P. Graham, Vivek Iyer, Scott M. Thompson, Michael S. Torbenson, Debabrata Mukhopadhyay, Sanjay MisraJCI Insight 2022 7 9
- Eleonora Gaetani, Elisabetta Peppucci, Fabiana Agostini, Luigi Di Martino, Emanuela Lucci Cordisco, Carmelo L. Sturiale, Alfredo Puca, Angelo Porfidia, Andrea Alexandre, Alessandro Pedicelli, Roberto PolaJournal of Clinical Medicine 2022 11 10
- Katsuhiro Mizutani, Arturo Consoli, Federico Di Maria, Stéphanie Condette Auliac, Anne Boulin, Oguzhan Coskun, Julie Gratieux, Georges RodeschJournal of Neurosurgery: Spine 2021 34 6
- Waleed Brinjikji, Giuseppe LanzinoNeurosurgery 2016 79 6
- Diana A. Olszewska, Sapna Rawal, Conor Fearon, Paula Alcaide‐Leon, Rick Stell, Vijayashankar Paramanandan, Tim Lynch, Tania Jawad, Padmaja Vittal, Brandon Barton, Hiroaki Miyajima, Satoshi Kono, Rukmini Mridula Kandadai, Rupam Borgohain, Anthony E. LangMovement Disorders Clinical Practice 2022 9 3
- Roxana Azma, Adam A. Dmytriw, Asthik Biswas, Mordechai Pollak, Felix Ratjen, Afsaneh Amirabadi, Helen M. Branson, Abhaya V. Kulkarni, Peter Dirks, Prakash MuthusamiPediatric Neurology 2022 129
- Omer F. Eker, Sophie Dupuis-Girod, Claire L. Shovlin, Edoardo BoccardiJournal of Clinical Medicine 2023 12 22
- Boris Lubicz, Florence ChristiaensDevelopmental Medicine & Child Neurology 2020 62 10
- K. P. Thompson, J. Nelson, H. Kim, S. M. Weinsheimer, D. A. Marchuk, M. T. Lawton, T. Krings, M. E. Faughnan, Murali Chakinala, Marianne S. Clancy, Marie E. Faughnan, James R. Gossage, Steven W. Hetts, Vivek Iyer, Raj S. Kasthuri, Helen Kim, Timo Krings, Michael T. Lawton, Doris Lin, Hans-Jurgen Mager, Douglas A. Marchuk, Justin P. McWilliams, Jamie McDonald, Ludmilla Pawlikowska, Jeffrey Pollak, Felix Ratjen, Karen Swanson, Dilini Vethanayagam, Shantel Weinsheimer, Andrew J. White, Pearce WilcoxOrphanet Journal of Rare Diseases 2021 16 1
- Lauren A. Beslow, Arastoo Vossough, Helen Kim, Jeffrey Nelson, Michael T. Lawton, Jeffrey Pollak, Doris D. M. Lin, Felix Ratjen, Adrienne M. Hammill, Steven W. Hetts, James R. Gossage, Kevin J. Whitehead, Marie E. Faughnan, Timo Krings, Mary E. Atherton, Murali M. Chakinala, Marianne S. Clancy, Marie E. Faughnan, James R. Gossage, Adrienne M. Hammill, Katharine Henderson, Steven Hetts, Peter Hountras, Vivek Iyer, Raj S. Kasthuri, Helen Kim, Timo Krings, Michael T. Lawton, Doris Lin, Johannes Jurgen Mager, Douglas A. Marchuk, Justin P. McWilliams, Jamie McDonald, Ludmila Pawlikowska, Jeffrey Pollak, Felix Ratjen, Karen Swanson, Dilini Vethanayagam, Shantel Weinsheimer, Andrew J. White, Pearce WilcoxChild's Nervous System 2024
- Lauren A. Beslow, Timo Krings, Helen Kim, Steven W. Hetts, Michael T. Lawton, Felix Ratjen, Kevin J. Whitehead, James R. Gossage, Charles E. McCulloch, Marianne Clancy, Negar Bagheri, Marie E. Faughnan, Mary E. Atherton, Murali M. Chakinala, Marianne S. Clancy, Marie E. Faughnan, James R. Gossage, Adrienne M. Hammill, Katharine Henderson, Steven Hetts, Peter Hountras, Vivek Iyer, Raj S. Kasthuri, Helen Kim, Timo Krings, Michael T. Lawton, Doris Lin, Johannes Jurgen Mager, Douglas A. Marchuk, Justin P. McWilliams, Jamie McDonald, Ludmila Pawlikowska, Jeffrey Pollak, Felix Ratjen, Karen Swanson, Dilini Vethanayagam, Shantel Weinsheimer, Andrew J. White, Kevin J. Whitehead, Pearce WilcoxPediatric Neurology 2024 155
- Luke L. Linscott, Anne G. Osborn, Justus F. Kleine2023
- Miral D. Jhaveri, Karen L. Salzman, Jeffrey S. Ross, Kevin R. Moore, Anne G. Osborn, Chang Yueh Ho2018
- T. Demerath, N. Kremers, U. Feige, H. UrbachZeitschrift für Epileptologie 2019 32 4
- Emiko Otsuka, Mineaki Kitamura, Kenji Sawase, Maiko Nakamura, Hiro Inoue, Kosei Yamaguchi, Satoshi Funakoshi, Takahiro Takazono, Hiroshi Mukae, Tomoya NishinoInternal Medicine 2024
- 2016
- 2016
- Waleed Brinjikji, Vivek Iyer, Giuseppe LanzinoClinical Neuroradiology 2020 30 2
- Steven Tessier, BrookeA Lipton, Firas Ido, Santo Longo, Sudip NandaInternational Journal of Critical Illness and Injury Science 2021 11 3
- How-Chung Cheng, Marie E. Faughnan, Karel G. terBrugge, Hon-Man Liu, Timo KringsAmerican Journal of Neuroradiology 2023 44 12
Advertisement
Neurovascular Manifestations in Hereditary Hemorrhagic Telangiectasia: Imaging Features and Genotype-Phenotype Correlations
T. Krings, H. Kim, S. Power, J. Nelson, M.E. Faughnan, W.L. Young, K.G. ter Brugge
American Journal of Neuroradiology Jan 2015, DOI: 10.3174/ajnr.A4210
Jump to section
Related Articles
Cited By...
- Prevalence and Characteristics of Intracranial Aneurysms in Hereditary Hemorrhagic Telangiectasia
- Endovascular treatment in the multimodality management of brain arteriovenous malformations: report of the Society of NeuroInterventional Surgery Standards and Guidelines Committee
- Comparison of MRI, MRA, and DSA for Detection of Cerebral Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia
- A theory for polymicrogyria and brain arteriovenous malformations in HHT
- Management of Brain Arteriovenous Malformations: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association
- Natural history of brain capillary vascular malformations in hereditary hemorrhagic telangiectasia patients
- Neurovascular Manifestations of Hereditary Hemorrhagic Telangiectasia: A Consecutive Series of 376 Patients during 15 Years
- Cerebrovascular Manifestations of Hereditary Hemorrhagic Telangiectasia
This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.
- Colin P. Derdeyn, Gregory J. Zipfel, Felipe C. Albuquerque, Daniel L. Cooke, Edward Feldmann, Jason P. Sheehan, James C. TornerStroke 2017 48 8
- Waleed Brinjikji, Vivek N. Iyer, Christopher P. Wood, Giuseppe LanzinoJournal of Neurosurgery 2017 127 2
- David S. Priemer, Alexander O. Vortmeyer, Shaobo Zhang, Hsim Yee Chang, Kendra L. Curless, Liang ChengHuman Pathology 2019 89
- W. Brinjikji, V. N. Iyer, V. Yamaki, G. Lanzino, H. J. Cloft, K. R. Thielen, K. L. Swanson, C. P. WoodAmerican Journal of Neuroradiology 2016 37 8
- Waleed Brinjikji, Vivek N. Iyer, Thomas Sorenson, Giuseppe LanzinoStroke 2015 46 11
- E. M. de Gussem, C. P. Edwards, A. E. Hosman, C. J. J. Westermann, R. J. Snijder, M. E. Faughnan, J. J. MagerOrphanet Journal of Rare Diseases 2016 11 1
- Guillaume Saliou, Mélanie Eyries, Marta Iacobucci, Jean‐François Knebel, Marie‐Christine Waill, Florence Coulet, Augustin Ozanne, Florent SoubrierAnnals of Neurology 2017 82 6
- Omer F. Eker, Edoardo Boccardi, Ulrich Sure, Maneesh C. Patel, Saverio Alicante, Ali Alsafi, Nicola Coote, Freya Droege, Olivier Dupuis, Annette Dam Fialla, Bryony Jones, Ujwal Kariholu, Anette D. Kjeldsen, David Lefroy, Gennaro M. Lenato, Hans Jurgen Mager, Guido Manfredi, Troels H. Nielsen, Fabio Pagella, Marco C. Post, Catherine Rennie, Carlo Sabbà, Patrizia Suppressa, Pernille M. Toerring, Sara Ugolini, Elisabetta Buscarini, Sophie Dupuis-Girod, Claire L. ShovlinOrphanet Journal of Rare Diseases 2020 15 1
- Masaki KOMIYAMANeurologia medico-chirurgica 2016 56 6
- Steven W. Hetts, Joseph T. Shieh, Michael A. Ohliger, Miles B. ConradRadiology 2021 300 1
More in this TOC Section
Similar Articles
Advertisement